{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:56:59Z","timestamp":1770746219253,"version":"3.49.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.bbrc.2014.04.017","type":"journal-article","created":{"date-parts":[[2014,4,13]],"date-time":"2014-04-13T11:30:52Z","timestamp":1397388652000},"page":"335-341","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Thiamine deficiency results in release of soluble factors that disrupt mitochondrial membrane potential and downregulate the glutamate transporter splice-variant GLT-1b in cultured astrocytes"],"prefix":"10.1016","volume":"448","author":[{"given":"Shivraj S.","family":"Jhala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan S.","family":"Hazell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2014.04.017_b0005","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1146\/annurev.physiol.63.1.795","article-title":"Dynamic signalling between astrocytes and neurons","volume":"63","author":"Araque","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbrc.2014.04.017_b0010","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1126\/science.298.5593.556","article-title":"New insights into neuron\u2013glia coupling","volume":"298","author":"Fields","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2014.04.017_b0015","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/00005072-198405000-00006","article-title":"Low energy levels in thiamine-deficient encephalopathy","volume":"43","author":"Aikawa","year":"1984","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbrc.2014.04.017_b0020","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neuint.2010.11.019","article-title":"Modeling neurodegenerative disease pathophysiology in thiamine deficiency: consequences of impaired oxidative metabolism","volume":"58","author":"Jhala","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbrc.2014.04.017_b0025","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1046\/j.1471-4159.2001.00436.x","article-title":"Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke\u2019s encephalopathy","volume":"78","author":"Hazell","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2014.04.017_b0030","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/glia.20908","article-title":"Loss of astrocytic glutamate transporters in Wernicke encephalopathy","volume":"58","author":"Hazell","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.bbrc.2014.04.017_b0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2004.11.014","article-title":"FT, TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition","volume":"1034","author":"Zou","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2014.04.017_b0040","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1046\/j.1471-4159.1997.68052216.x","article-title":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) decreases glutamate uptake in cultured astrocytes","volume":"68","author":"Hazell","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2014.04.017_b0045","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1523\/JNEUROSCI.22-06-02142.2002","article-title":"Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain","volume":"22","author":"Chen","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2014.04.017_b0050","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/glia.10241","article-title":"Thiamine deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytes","volume":"43","author":"Hazell","year":"2003","journal-title":"Glia"},{"key":"10.1016\/j.bbrc.2014.04.017_b0055","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1046\/j.1471-4159.1997.69062612.x","article-title":"Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia","volume":"69","author":"Gegelashvili","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2014.04.017_b0060","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1523\/JNEUROSCI.17-03-00932.1997","article-title":"Neuronal regulation of glutamate transporter subtype expression in astrocytes","volume":"17","author":"Swanson","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2014.04.017_b0065","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/1097-4547(20001015)62:2<286::AID-JNR13>3.0.CO;2-0","article-title":"Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: an in vitro model for the study of cell death mechanisms in Wernicke\u2019s encephalopathy","volume":"62","author":"Pannunzio","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbrc.2014.04.017_b0070","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1460-9568.2006.04651.x","article-title":"Gene expression changes in thalamus and inferior colliculus associated with inflammation, cellular stress, metabolism and structural damage in thiamine deficiency","volume":"23","author":"Vemuganti","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbrc.2014.04.017_b0075","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.nbd.2007.01.011","article-title":"Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism","volume":"26","author":"Karuppagounder","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbrc.2014.04.017_b0080","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1096\/fasebj.9.15.8529837","article-title":"TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function","volume":"9","author":"Benveniste","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2014.04.017_b0085","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/35094583","article-title":"Cytokines and acute neurodegeneration","volume":"2","author":"Allan","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2014.04.017_b0090","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1161\/01.STR.25.7.1481","article-title":"Tumor necrosis factor-alpha expression in ischemic neurons","volume":"25","author":"Liu","year":"1994","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2014.04.017_b0095","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF02815404","article-title":"Concomitant cortical expression of TNF-alpha and IL-1 beta mRNAs follows early response gene expression in transient focal ischemia","volume":"23","author":"Wang","year":"1994","journal-title":"Mol. Chem. Neuropathol."},{"key":"10.1016\/j.bbrc.2014.04.017_b0100","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1006\/bbrc.1994.2228","article-title":"Tumour necrosis factor alpha and interleukin-1 beta induce specific subunits of NFKB to bind the HIV-1 enhancer: characterisation of transcription factors controlling human immunodeficiency virus type 1 gene expression in neural cells","volume":"203","author":"Swingler","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14006482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14006482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T13:32:05Z","timestamp":1565357525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X14006482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0006291X14006482"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.04.017","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thiamine deficiency results in release of soluble factors that disrupt mitochondrial membrane potential and downregulate the glutamate transporter splice-variant GLT-1b in cultured astrocytes","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}