{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:11:32Z","timestamp":1792098692309,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"VA Merit Award"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AR058005"],"award-info":[{"award-number":["R01AR058005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.bbrc.2014.05.005","type":"journal-article","created":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T13:17:26Z","timestamp":1399727846000},"page":"151-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Adipocyte induced arterial calcification is prevented with sodium thiosulfate"],"prefix":"10.1016","volume":"449","author":[{"given":"Neal X.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalisha","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader Kassis","family":"Akl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Moe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2014.05.005_b0005","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00467-003-1276-0","article-title":"Calciphylaxis and vascular calcification: a continuum of extra-skeletal osteogenesis","volume":"18","author":"Moe","year":"2003","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.bbrc.2014.05.005_b0010","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1053\/ajkd.1998.v32.pm9740153","article-title":"Cutaneous necrosis from calcific uremic arteriolopathy [see comments]","volume":"32","author":"Coates","year":"1998","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.bbrc.2014.05.005_b0015","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1053\/ajkd.2001.24533","article-title":"Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells","volume":"37","author":"Ahmed","year":"2001","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.bbrc.2014.05.005_b0020","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1046\/j.1523-1755.2002.00375.x","article-title":"Calciphylaxis is usually non-ulcerating: risk factors, outcome and therapy","volume":"61","author":"Fine","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2014.05.005_b0025","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2147\/IJGM.S47397","article-title":"Warfarin-induced calciphylaxis: a case report and review of literature","volume":"6","author":"Saifan","year":"2013","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.bbrc.2014.05.005_b0030","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/ki.2008.502","article-title":"Treatment of vascular calcification","volume":"74","author":"O\u2019Neill","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2014.05.005_b0035","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrneph.2009.99","article-title":"Sodium thiosulfate in the treatment of calcific uremic arteriolopathy","volume":"5","author":"Schlieper","year":"2009","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbrc.2014.05.005_b0040","doi-asserted-by":"crossref","first-page":"485","DOI":"10.5414\/CNP75485","article-title":"Efficacy of sodium thiosulfate for the treatment for calciphylaxis","volume":"75","author":"Noureddine","year":"2011","journal-title":"Clin. Nephrol."},{"key":"10.1016\/j.bbrc.2014.05.005_b0045","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1046\/j.1523-1755.2002.00170.x","article-title":"Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins","volume":"61","author":"Moe","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2014.05.005_b0050","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1046\/j.1523-1755.2002.00625.x","article-title":"Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells","volume":"62","author":"Chen","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2014.05.005_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ahj.2012.09.018","article-title":"Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease","volume":"164","author":"Tamez","year":"2012","journal-title":"Am. Heart J."},{"key":"10.1016\/j.bbrc.2014.05.005_b0060","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/ki.2012.322","article-title":"Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet","volume":"82","author":"Lau","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2014.05.005_b0065","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ki.2009.481","article-title":"Verapamil inhibits calcification and matrix vesicle activity of bovine vascular smooth muscle cells","volume":"77","author":"Chen","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2014.05.005_b0070","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/ki.1973.104","article-title":"Nature of soft tissue calcification in uremia","volume":"4","author":"Contiguglia","year":"1973","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2014.05.005_b0075","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1053\/j.ajkd.2013.03.042","article-title":"Phosphate homeostasis in CKD: report of a scientific symposium sponsored by the National Kidney Foundation","volume":"62","author":"Block","year":"2013","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.bbrc.2014.05.005_b0080","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1053\/ajkd.1998.v32.pm9740152","article-title":"A case control study of proximal calciphylaxis [see comments]","volume":"32","author":"Bleyer","year":"1998","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.bbrc.2014.05.005_b0085","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1046\/j.1523-1755.2001.00803.x","article-title":"Risk factors and mortality associated with calciphylaxis in end-stage renal disease","volume":"60","author":"Mazhar","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2014.05.005_b0090","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1046\/j.1523-1755.2002.00145.x","article-title":"Relevance of C-reactive protein levels in peritoneal dialysis patients","volume":"61","author":"Fine","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2014.05.005_b0190","first-page":"25","article-title":"Sodium thiosulfate, bisphosphonates, and cinacalcet for calciphylaxis","volume":"19","author":"Raymond","year":"2009","journal-title":"CANNT J."},{"key":"10.1016\/j.bbrc.2014.05.005_b0100","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2014.05.005_b0105","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1128\/MCB.15.4.1858","article-title":"Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene","volume":"15","author":"Ducy","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2014.05.005_b0110","doi-asserted-by":"crossref","first-page":"622","DOI":"10.2353\/ajpath.2010.091292","article-title":"Therapeutic effects of vitamin D analogs on cardiac hypertrophy in spontaneously hypertensive rats","volume":"177","author":"Kong","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2014.05.005_b0115","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.numecd.2009.07.009","article-title":"Vitamin D deficiency in the spontaneously hypertensive heart failure [SHHF] prone rat","volume":"20","author":"Przybylski","year":"2010","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.bbrc.2014.05.005_b0120","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1089\/scd.2010.0140","article-title":"Human bone marrow and adipose tissue mesenchymal stem cells: a user\u2019s guide","volume":"19","author":"Mosna","year":"2010","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bbrc.2014.05.005_b0125","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.cardfail.2011.08.006","article-title":"Doxercalciferol, a pro-hormone of vitamin D, prevents the development of cardiac hypertrophy in rats","volume":"17","author":"Choi","year":"2011","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.bbrc.2014.05.005_b0130","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/107632704323061744","article-title":"Subcutaneous adipocytes can differentiate into bone-forming cells in vitro and in vivo","volume":"10","author":"Justesen","year":"2004","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bbrc.2014.05.005_b0135","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00223-011-9461-9","article-title":"Overexpression of Runx2 and MKP-1 stimulates transdifferentiation of 3T3-L1 preadipocytes into bone-forming osteoblasts in vitro","volume":"88","author":"Takahashi","year":"2011","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbrc.2014.05.005_b0140","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mce.2009.08.018","article-title":"Adipose tissue as an endocrine organ","volume":"316","author":"Galic","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbrc.2014.05.005_b0145","doi-asserted-by":"crossref","first-page":"982458","DOI":"10.1155\/2013\/982458","article-title":"VEGF in the crosstalk between human adipocytes and smooth muscle cells: depot-specific release from visceral and perivascular adipose tissue","volume":"2013","author":"Schlich","year":"2013","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bbrc.2014.05.005_b0150","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1161\/ATVBAHA.109.195255","article-title":"Effect of leptin on vascular calcification in apolipoprotein E-deficient mice","volume":"29","author":"Zeadin","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2014.05.005_b0155","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.bbrc.2012.08.011","article-title":"Leptin promotes osteoblast differentiation and mineralization of primary cultures of vascular smooth muscle cells by inhibiting glycogen synthase kinase (GSK)-3beta","volume":"425","author":"Zeadin","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2014.05.005_b0160","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s00223-007-9073-6","article-title":"Regulation of in vitro vascular calcification by BMP4, VEGF and Wnt3a","volume":"81","author":"Mikhaylova","year":"2007","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbrc.2014.05.005_b0165","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/ki.2008.455","article-title":"Sodium thiosulfate prevents vascular calcifications in uremic rats","volume":"74","author":"Pasch","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2014.05.005_b0170","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1681\/ASN.2008070754","article-title":"Thiosulfate reduces calcium phosphate nephrolithiasis","volume":"20","author":"Asplin","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2014.05.005_b0175","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/ndt\/gfr375","article-title":"The chemistry of thiosulfate and vascular calcification","volume":"27","author":"O\u2019Neill","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbrc.2014.05.005_b0180","first-page":"63","article-title":"Successful sodium thiosulphate treatment for recurrent calcium urolithiasis","volume":"23","author":"Yatzidis","year":"1985","journal-title":"Clin. Nephrol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1400850X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1400850X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T02:58:58Z","timestamp":1538621938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X1400850X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0006291X1400850X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.05.005","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adipocyte induced arterial calcification is prevented with sodium thiosulfate","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}