{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:49:12Z","timestamp":1773409752580,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.bbrc.2014.08.147","type":"journal-article","created":{"date-parts":[[2014,9,6]],"date-time":"2014-09-06T12:28:40Z","timestamp":1410006520000},"page":"768-774","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Pre-clinical evaluation of cinobufotalin as a potential anti-lung cancer agent"],"prefix":"10.1016","volume":"452","author":[{"given":"Sheng","family":"Kai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-huan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-ping","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2014.08.147_b0005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/ng1001-117","article-title":"TGF-beta signaling in tumor suppression and cancer progression","volume":"29","author":"Derynck","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2014.08.147_b0010","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1161\/01.CIR.87.5.1776","article-title":"Diagnosis and therapy of Kawasaki disease in children","volume":"87","author":"Dajani","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2014.08.147_b0015","doi-asserted-by":"crossref","first-page":"16806","DOI":"10.1073\/pnas.0603916103","article-title":"Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells","volume":"103","author":"Gadue","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2014.08.147_b0020","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1101\/gad.1388806","article-title":"Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells","volume":"20","author":"Jian","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2014.08.147_b0025","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.jpeds.2010.10.012","article-title":"Infliximab for intravenous immunoglobulin resistance in Kawasaki disease: a retrospective study","volume":"158","author":"Son","year":"2011","journal-title":"J. Pediatr."},{"key":"10.1016\/j.bbrc.2014.08.147_b0030","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.molmed.2007.07.001","article-title":"From traditional Chinese medicine to rational cancer therapy","volume":"13","author":"Efferth","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbrc.2014.08.147_b0035","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/157016310791162794","article-title":"Molecular basis of traditional Chinese medicine in cancer chemoprevention","volume":"7","author":"Wang","year":"2010","journal-title":"Curr. Drug Discov. Technol."},{"key":"10.1016\/j.bbrc.2014.08.147_b0040","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cbi.2012.07.005","article-title":"Apoptotic cell death by the novel natural compound, cinobufotalin","volume":"199","author":"Emam","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbrc.2014.08.147_b0045","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3181\/00379727-76-18493","article-title":"Comparison of cardiac action of bufalin, cinobufotalin, and telocinobufagin with cinobufagin","volume":"76","author":"Chen","year":"1951","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.bbrc.2014.08.147_b0050","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.7314\/APJCP.2012.13.11.5339","article-title":"Anti-tumor activity and apoptosis-regulation mechanisms of bufalin in various cancers: new hope for cancer patients","volume":"13","author":"Yin","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.bbrc.2014.08.147_b0055","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fphys.2013.00076","article-title":"Mitochondrial permeability transition and cell death: the role of cyclophilin d","volume":"4","author":"Javadov","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2014.08.147_b0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0300-9084(02)01375-5","article-title":"The permeability transition pore complex: another view","volume":"84","author":"Halestrap","year":"2002","journal-title":"Biochimie"},{"key":"10.1016\/j.bbrc.2014.08.147_b0065","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s10495-006-0525-7","article-title":"Role of the mitochondrial membrane permeability transition in cell death","volume":"12","author":"Tsujimoto","year":"2007","journal-title":"Apoptosis"},{"issue":"Pt 2","key":"10.1016\/j.bbrc.2014.08.147_b0070","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/bj3360287","article-title":"Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition","volume":"336","author":"Woodfield","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2014.08.147_b0075","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1046\/j.1432-1327.1998.2580729.x","article-title":"Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore","volume":"258","author":"Crompton","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbrc.2014.08.147_b0080","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11010-013-1922-1","article-title":"The mitochondrial cyclophilin D\/p53 complexation mediates doxorubicin-induced non-apoptotic death of A549 lung cancer cells","volume":"389","author":"Lu","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2014.08.147_b0085","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1128\/MCB.23.16.5836-5848.2003","article-title":"Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair","volume":"23","author":"Ding","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2014.08.147_b0090","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.24589","article-title":"P53 dependent mitochondrial permeability transition pore opening is required for dexamethasone-induced death of osteoblasts","author":"Zhen","year":"2014","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.bbrc.2014.08.147_b0095","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1002\/jcp.24589","article-title":"P53 dependent mitochondrial permeability transition pore opening is required for dexamethasone-induced death of osteoblasts","volume":"229","author":"Zhen","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbrc.2014.08.147_b0100","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s00280-010-1374-1","article-title":"C6 ceramide potentiates curcumin-induced cell death and apoptosis in melanoma cell lines in vitro","volume":"66","author":"Yu","year":"2010","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.bbrc.2014.08.147_b0105","doi-asserted-by":"crossref","first-page":"6557","DOI":"10.1038\/onc.2010.379","article-title":"Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition","volume":"29","author":"Ji","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2014.08.147_b0110","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1101\/gad.13.4.382","article-title":"The prosurvival Bcl-2 homolog Bfl-1\/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis","volume":"13","author":"Zong","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2014.08.147_b0115","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nm.1868","article-title":"Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer\u2019s disease","volume":"14","author":"Du","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2014.08.147_b0120","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.neurobiolaging.2009.03.003","article-title":"Cyclophilin D deficiency improves mitochondrial function and learning\/memory in aging Alzheimer disease mouse model","volume":"32","author":"Du","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbrc.2014.08.147_b0125","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1359-6101(02)00004-7","article-title":"Recent advances in TGF-beta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders","volume":"13","author":"Grimaud","year":"2002","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbrc.2014.08.147_b0130","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.cell.2012.05.014","article-title":"P53 opens the mitochondrial permeability transition pore to trigger necrosis","volume":"149","author":"Vaseva","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2014.08.147_b0135","doi-asserted-by":"crossref","first-page":"34793","DOI":"10.1074\/jbc.M202191200","article-title":"Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A","volume":"277","author":"Clarke","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2014.08.147_b0140","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2014.08.147_b0145","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.bbrc.2013.06.103","article-title":"Cisplatin-induced non-apoptotic death of pancreatic cancer cells requires mitochondrial cyclophilin-D-p53 signaling","volume":"437","author":"Chen","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2014.08.147_b0150","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1042\/BST0340232","article-title":"Calcium, mitochondria and reperfusion injury: a pore way to die","volume":"34","author":"Halestrap","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbrc.2014.08.147_b0155","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1161\/CIRCRESAHA.112.280990","article-title":"Is p53 the long-sought molecular trigger for cyclophilin D-regulated mitochondrial permeability transition pore formation and necrosis?","volume":"111","author":"Karch","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2014.08.147_b0160","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nature03317","article-title":"Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death","volume":"434","author":"Nakagawa","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2014.08.147_b0165","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.bbrc.2012.07.160","article-title":"Ultra-violet B (UVB)-induced skin cell death occurs through a cyclophilin D intrinsic signaling pathway","volume":"425","author":"Ji","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14015897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14015897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:10:22Z","timestamp":1757761822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X14015897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0006291X14015897"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.08.147","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-clinical evaluation of cinobufotalin as a potential anti-lung cancer agent","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.08.147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}