{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:42:57Z","timestamp":1791268977606,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR048997"],"award-info":[{"award-number":["R01AR048997"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.bbrc.2014.09.020","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T05:32:11Z","timestamp":1410413531000},"page":"958-961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Mitogen-activated protein kinase kinase 1\/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A\/C gene mutation"],"prefix":"10.1016","volume":"452","author":[{"given":"Antoine","family":"Muchir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusako","family":"Sera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Worman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2014.09.020_b0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/6799","article-title":"Mutations in the gene encoding lamin A\/C cause autosomal dominant Emery\u2013Dreifuss muscular dystrophy","volume":"21","author":"Bonne","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2014.09.020_b0010","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1056\/NEJM199912023412302","article-title":"Missense mutations in the rod domain of the lamin A\/C gene as causes of dilated cardiomyopathy and conduction-system disease","volume":"341","author":"Fatkin","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2014.09.020_b0015","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/hmg\/9.9.1453","article-title":"Identification of mutations in the gene encoding lamins A\/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B)","volume":"9","author":"Muchir","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2014.09.020_b0020","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.CIR.101.5.473","article-title":"Lamin A\/C gene mutation associated with dilated cardiomyopathy with variable skeletal muscle involvement","volume":"101","author":"Brodsky","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2014.09.020_b0025","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/1531-8249(200008)48:2<170::AID-ANA6>3.0.CO;2-J","article-title":"Clinical and molecular genetic spectrum of autosomal dominant Emery\u2013Dreifuss muscular dystrophy due to mutations of the lamin A\/C gene","volume":"48","author":"Bonne","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbrc.2014.09.020_b0030","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0735-1097(02)02954-6","article-title":"Natural history of dilated cardiomyopathy due to lamin A\/C gene mutations","volume":"41","author":"Taylor","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2014.09.020_b0035","doi-asserted-by":"crossref","first-page":"16161","DOI":"10.1016\/j.ahj.2008.01.026","article-title":"Lamin A\/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy","volume":"156","author":"Parks","year":"2008","journal-title":"Am. Heart J."},{"key":"10.1016\/j.bbrc.2014.09.020_b0040","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0735-1097(02)01724-2","article-title":"Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A\/C defect-related disease","volume":"39","author":"Arbustini","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2014.09.020_b0045","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00109-004-0589-1","article-title":"Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A\/C mutations portend a high risk of sudden death?","volume":"83","author":"van Berlo","year":"2005","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.bbrc.2014.09.020_b0050","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.jacc.2008.06.044","article-title":"Long-term outcome and risk stratification in dilated cardiolaminopathies","volume":"52","author":"Pasotti","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2014.09.020_b0055","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1242\/dmm.006346","article-title":"LMNA cardiomyopathy: cell biology and genetics meet clinical medicine","volume":"4","author":"Lu","year":"2011","journal-title":"Dis. Models Mech."},{"key":"10.1016\/j.bbrc.2014.09.020_b0060","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jacc.2011.08.078","article-title":"Risk factors for malignant ventricular arrhythmias in lamin a\/c mutation carriers a European cohort study","volume":"59","author":"van Rijsingen","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2014.09.020_b0065","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1056\/NEJMc052632","article-title":"Primary prevention of sudden death in patients with lamin A\/C gene mutations","volume":"354","author":"Meune","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2014.09.020_b0070","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1172\/JCI29042","article-title":"Activation of MAPK pathway links LMNA mutations to cardiomyopathy in Emery\u2013Dreifuss muscular dystrophy","volume":"117","author":"Muchir","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2014.09.020_b0075","doi-asserted-by":"crossref","first-page":"144ra102","DOI":"10.1126\/scitranslmed.3003875","article-title":"Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A\/C gene mutation","volume":"4","author":"Choi","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbrc.2014.09.020_b0080","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/hmg\/ddn343","article-title":"Inhibition of extracellular signal-regulate kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins","volume":"18","author":"Muchir","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2014.09.020_b0085","first-page":"632","article-title":"Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene","volume":"2010","author":"Wu","year":"1802","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2014.09.020_b0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1161\/CIRCULATIONAHA.110.970673","article-title":"Mitogen activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by lamin A\/C gene mutation","volume":"123","author":"Wu","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2014.09.020_b0095","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1093\/hmg\/dds265","article-title":"Abnormal p38\u03b1 mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A\/C gene mutation","volume":"21","author":"Muchir","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2014.09.020_b0100","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/cvr\/cvr301","article-title":"Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A\/C gene","volume":"93","author":"Muchir","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2014.09.020_b0105","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/hmg\/ddi017","article-title":"Mouse model carrying H222P-Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies","volume":"14","author":"Arimura","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2014.09.020_b0110","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0735-1097(83)80230-7","article-title":"Vasodilator and inotropic therapy for severe chronic heart failure: passion and skepticism","volume":"2","author":"Packer","year":"1983","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2014.09.020_b0115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1750-1172-1-27","article-title":"Cardiomyopathy, familial dilated","volume":"1","author":"Taylor","year":"2006","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.bbrc.2014.09.020_b0120","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/eurjhf\/hfs033","volume":"14","author":"McMurray","year":"2012","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.bbrc.2014.09.020_b0125","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jjcc.2008.08.013","article-title":"Beneficial effects of beta-blockers and angiotensin-converting enzyme inhibitors in Duchenne muscular dystrophy","volume":"53","author":"Ogata","year":"2009","journal-title":"J. Cardiol."},{"key":"10.1016\/j.bbrc.2014.09.020_b0130","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.amjcard.2012.02.064","article-title":"Effects of angiotensin-converting enzyme inhibitors and\/or beta blockers on the cardiomyopathy in Duchenne muscular dystrophy","volume":"110","author":"Viollet","year":"2012","journal-title":"Am. J. Cardiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14016283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14016283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:29:46Z","timestamp":1762093786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X14016283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0006291X14016283"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.09.020","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitogen-activated protein kinase kinase 1\/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A\/C gene mutation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}