{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:58:18Z","timestamp":1768913898743,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.bbrc.2014.09.028","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T02:02:07Z","timestamp":1410832927000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["AMP-activated protein kinase activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis"],"prefix":"10.1016","volume":"453","author":[{"given":"Guoqiang","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanhuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenwan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2014.09.028_b0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrc703","article-title":"Helicobacter pylori and gastrointestinal tract adenocarcinomas","volume":"2","author":"Peek","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2014.09.028_b0010","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"1297\u20131307","key":"10.1016\/j.bbrc.2014.09.028_b0015","first-page":"e1291","article-title":"Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis","volume":"136","author":"Yan","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2014.09.028_b0020","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1053\/j.gastro.2009.02.014","article-title":"Acetylation of apurinic\/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis","volume":"136","author":"Bhattacharyya","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2014.09.028_b0025","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1053\/j.gastro.2008.01.072","article-title":"Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family","volume":"134","author":"Wei","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2014.09.028_b0030","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1084\/jem.187.10.1659","article-title":"The effect of class II major histocompatibility complex expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells: a mechanism for T helper cell type 1-mediated damage","volume":"187","author":"Fan","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2014.09.028_b0035","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1172\/JCI2808","article-title":"Involvement of the CD95 (APO-1\/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis","volume":"102","author":"Rudi","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2014.09.028_b0040","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1086\/315788","article-title":"In vivo disruption of the fas pathway abrogates gastric growth alterations secondary to Helicobacter infection","volume":"182","author":"Houghton","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bbrc.2014.09.028_b0045","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s00011-010-0245-x","article-title":"Helicobacter pylori: a ROS-inducing bacterial species in the stomach","volume":"59","author":"Handa","year":"2010","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbrc.2014.09.028_b0050","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1136\/gut.2003.024372","article-title":"Bax translocation and mitochondrial fragmentation induced by Helicobacter pylori","volume":"53","author":"Ashktorab","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.bbrc.2014.09.028_b0055","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrc1433","article-title":"Oncogenic mechanisms of the Helicobacter pylori CagA protein","volume":"4","author":"Hatakeyama","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2014.09.028_b0060","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature09932","article-title":"Structure of mammalian AMPK and its regulation by ADP","volume":"472","author":"Xiao","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2014.09.028_b0065","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2012.12.016","article-title":"Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy","volume":"152","author":"Kim","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2014.09.028_b0070","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2014.09.028_b0075","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2014.09.028_b0080","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature11066","article-title":"AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress","volume":"485","author":"Jeon","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2014.09.028_b0085","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.cell.2006.06.055","article-title":"TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth","volume":"126","author":"Inoki","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2014.09.028_b0090","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0092-8674(03)00929-2","article-title":"TSC2 mediates cellular energy response to control cell growth and survival","volume":"115","author":"Inoki","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2014.09.028_b0095","doi-asserted-by":"crossref","first-page":"16879","DOI":"10.1074\/jbc.M110.186932","article-title":"AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3beta (GSK-3beta) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane","volume":"286","author":"Zhang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2014.09.028_b0100","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1002\/mnfr.200800592","article-title":"EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells","volume":"53","author":"Huang","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.bbrc.2014.09.028_b0105","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1074\/jbc.M112.390245","volume":"288","author":"Chi","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2014.09.028_b0110","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1093\/jnci\/djr243","article-title":"Modulation of pancreatic cancer chemoresistance by inhibition of TAK1","volume":"103","author":"Melisi","year":"2011","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbrc.2014.09.028_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellsig.2013.08.046","article-title":"Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: new implications for osteonecrosis treatment?","volume":"26","author":"She","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2014.09.028_b0120","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cmet.2006.05.005","article-title":"Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome","volume":"3","author":"Cool","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2014.09.028_b0125","doi-asserted-by":"crossref","first-page":"7217","DOI":"10.1073\/pnas.0610068104","article-title":"Resveratrol stimulates AMP kinase activity in neurons","volume":"104","author":"Dasgupta","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2014.09.028_b0130","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1038\/embor.2009.210","article-title":"Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination","volume":"10","author":"Lamb","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbrc.2014.09.028_b0135","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1128\/IAI.74.3.1452-1461.2006","article-title":"Helicobacter pylori induces IkappaB kinase alpha nuclear translocation and chemokine production in gastric epithelial cells","volume":"74","author":"Hirata","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbrc.2014.09.028_b0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11010-013-1568-z","article-title":"TAK1 activates AMPK-dependent cell death pathway in hydrogen peroxide-treated cardiomyocytes, inhibited by heat shock protein-70","volume":"377","author":"Chen","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2014.09.028_b0145","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/emboj.2009.8","article-title":"TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells","volume":"28","author":"Herrero-Martin","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2014.09.028_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2013.05.090","article-title":"Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis","volume":"437","author":"Wang","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2014.09.028_b0155","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3748\/wjg.v20.i6.1438","article-title":"A review of Helicobacter pylori diagnosis, treatment, and methods to detect eradication","volume":"20","author":"Garza-Gonzalez","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2014.09.028_b0160","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.canlet.2013.08.016","article-title":"Helicobacter pylori-induced gastric inflammation and gastric cancer","volume":"345","author":"Wang","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2014.09.028_b0165","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMPK signalling pathway coordinates cell growth, autophagy and metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2014.09.028_b0170","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.chembiol.2012.08.019","article-title":"AMP-activated protein kinase: a target for drugs both ancient and modern","volume":"19","author":"Hardie","year":"2012","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bbrc.2014.09.028_b0175","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2014.09.028_b0180","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","article-title":"The LKB1-AMPK pathway: metabolism and growth control in tumour suppression","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2014.09.028_b0185","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nrm2249","article-title":"AMP-activated\/SNF1 protein kinases: conserved guardians of cellular energy","volume":"8","author":"Hardie","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2014.09.028_b0190","doi-asserted-by":"crossref","first-page":"E1308","DOI":"10.1152\/ajpendo.00456.2006","article-title":"Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction","volume":"292","author":"Jensen","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14016362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14016362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T16:24:30Z","timestamp":1538238270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X14016362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0006291X14016362"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.09.028","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AMP-activated protein kinase activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.09.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}