{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:04:03Z","timestamp":1791306243204,"version":"4.3.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31101007"],"award-info":[{"award-number":["31101007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470855"],"award-info":[{"award-number":["81470855"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2011CDB364"],"award-info":[{"award-number":["2011CDB364"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003172","name":"HUST","doi-asserted-by":"publisher","award":["2013QN173"],"award-info":[{"award-number":["2013QN173"]}],"id":[{"id":"10.13039\/501100003172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.bbrc.2014.10.076","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T19:23:03Z","timestamp":1414005783000},"page":"328-334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Hypoxia-inducible factor-1alpha regulates autophagy to activate hepatic stellate cells"],"prefix":"10.1016","volume":"454","author":[{"given":"Jing","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanju","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6908-4842","authenticated-orcid":false,"given":"Chunwei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2014.10.076_b0005","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cbi.2011.07.001","article-title":"Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches","volume":"193","author":"Mormone","year":"2011","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbrc.2014.10.076_b0010","doi-asserted-by":"crossref","first-page":"11684","DOI":"10.3748\/wjg.v20.i33.11684","article-title":"Diagnosis of alcoholic liver disease","volume":"20","author":"Torruellas","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2014.10.076_b0015","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1172\/JCI66028","article-title":"Evolving therapies for liver fibrosis","volume":"123","author":"Schuppan","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2014.10.076_b0020","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2014.10.076_b0025","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.phrs.2012.07.003","article-title":"Targeting autophagy for the treatment of liver diseases","volume":"66","author":"Ni","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2014.10.076_b0030","first-page":"972","article-title":"Autophagy and mesenchymal cell fibrogenesis","volume":"1831","author":"Hilscher","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2014.10.076_b0035","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.chom.2009.05.016","article-title":"Autophagy, immunity, and microbial adaptations","volume":"5","author":"Deretic","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbrc.2014.10.076_b0040","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.jhep.2011.08.001","article-title":"Autophagy and hepatic stellate cell activation \u2013 partners in crime?","volume":"55","author":"Hsu","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2014.10.076_b0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4331\/wjbc.v1.i1.3","article-title":"Role of autophagy in liver physiology and pathophysiology","volume":"1","author":"Wx","year":"2010","journal-title":"World J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2014.10.076_b0050","doi-asserted-by":"crossref","first-page":"849","DOI":"10.4161\/auto.19947","article-title":"Autophagy fuels tissue fibrogenesis","volume":"8","author":"H-G","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2014.10.076_b0055","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/hep.25497","article-title":"Hypoxia and hypoxia inducible factors: diverse roles in liver diseases","volume":"55","author":"Nath","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2014.10.076_b0060","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1128\/MCB.22.1.12-22.2002","article-title":"c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription","volume":"22","author":"Alfranca","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2014.10.076_b0065","doi-asserted-by":"crossref","first-page":"e74051","DOI":"10.1371\/journal.pone.0074051","article-title":"Hypoxia-inducible factor-1alpha and MAPK co-regulate activation of hepatic stellate cells upon hypoxia stimulation","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2014.10.076_b0070","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.3748\/wjg.v19.i9.1405","article-title":"Exogenous bone morphogenetic protein-7 reduces hepatic fibrosis in Schistosoma japonicum-infected mice via transforming growth factor-beta\/Smad signaling","volume":"19","author":"Chen","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2014.10.076_b0075","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1399-0039.2011.01809.x","article-title":"The dynamic expression of allograft inflammatory factor-1 in hepatic tissues and splenic cells of BALB\/c mice with Schistosoma japonicum infection","volume":"79","author":"Chen","year":"2012","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.bbrc.2014.10.076_b0080","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis","volume":"54","author":"Xu","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.bbrc.2014.10.076_b0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/jcs.140426","article-title":"The LC3 interactome at a glance","volume":"127","author":"Wild","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrc.2014.10.076_b0090","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2014.10.076_b0095","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1016\/j.biocel.2004.02.005","article-title":"Methods for monitoring autophagy","volume":"36","author":"Mizushima","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2014.10.076_b0100","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3390\/cells1030617","article-title":"How human tumor viruses make use of autophagy","volume":"1","author":"Pratt","year":"2012","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2014.10.076_b0105","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1248\/bpb.b14-00297","article-title":"Chloroquine improved carbon tetrachloride-induced liver fibrosis through its inhibition of the activation of hepatic stellate cells: role of autophagy","volume":"37","author":"He","year":"2014","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbrc.2014.10.076_b0110","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1582-4934.2006.tb00292.x","article-title":"Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-\u03b2 as major players and therapeutic targets","volume":"10","author":"Gressner","year":"2006","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbrc.2014.10.076_b0115","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1158\/0008-5472.CAN-11-3831","article-title":"Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma","volume":"72","author":"Hu","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2014.10.076_b0120","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.jhep.2011.07.010","article-title":"A role for autophagy during hepatic stellate cell activation","volume":"55","author":"Thoen","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2014.10.076_b0125","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ceb.2009.11.014","article-title":"Mammalian autophagy: core molecular machinery and signaling regulation","volume":"22","author":"Yang","year":"2010","journal-title":"Curr. Opin. Cell Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14018853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14018853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T10:51:15Z","timestamp":1589280675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X14018853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0006291X14018853"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.10.076","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia-inducible factor-1alpha regulates autophagy to activate hepatic stellate cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.10.076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}