{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:45:12Z","timestamp":1790027112580,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2012R1A2A2A01043867"],"award-info":[{"award-number":["2012R1A2A2A01043867"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2012R1A2A1A03670452"],"award-info":[{"award-number":["2012R1A2A1A03670452"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health and Welfare of the Republic of Korea","award":["A111345"],"award-info":[{"award-number":["A111345"]}]},{"name":"Ministry of Health and Welfare of the Republic of Korea","award":["HI14C1234"],"award-info":[{"award-number":["HI14C1234"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.bbrc.2014.10.147","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T18:03:50Z","timestamp":1415210630000},"page":"212-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH"],"prefix":"10.1016","volume":"455","author":[{"given":"Kwi-Hyun","family":"Bae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ae-Kyung","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Guk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Kyu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun-Gyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2014.10.147_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.33549\/physiolres.931610","article-title":"Fibroblast growth factor 21: a novel metabolic regulator with potential therapeutic properties in obesity\/type 2 diabetes mellitus","volume":"58","author":"Dostalova","year":"2009","journal-title":"Physiol. Res."},{"key":"10.1016\/j.bbrc.2014.10.147_b0010","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI23606","article-title":"FGF-21 as a novel metabolic regulator","volume":"115","author":"Kharitonenkov","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2014.10.147_b0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cmet.2008.05.006","article-title":"Inhibition of growth hormone signaling by the fasting-induced hormone FGF21","volume":"8","author":"Inagaki","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2014.10.147_b0020","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1210\/en.2006-1168","article-title":"The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21","volume":"148","author":"Kharitonenkov","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2014.10.147_b0025","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cmet.2007.05.003","article-title":"Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21","volume":"5","author":"Inagaki","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2014.10.147_b0030","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1210\/en.2013-1758","article-title":"Orphan nuclear receptor nur77 mediates fasting-induced hepatic fibroblast growth factor 21 expression","volume":"155","author":"Min","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2014.10.147_b0035","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1210\/en.2013-1490","article-title":"Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor alpha to regulate metabolic hormone FGF21","volume":"155","author":"Kim","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2014.10.147_b0040","doi-asserted-by":"crossref","first-page":"10490","DOI":"10.1074\/jbc.M112.429852","article-title":"Retinoic acid receptor beta stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice","volume":"288","author":"Li","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2014.10.147_b0045","doi-asserted-by":"crossref","first-page":"15668","DOI":"10.1074\/jbc.M110.102160","article-title":"Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha","volume":"285","author":"Wang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2014.10.147_b0050","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1093\/nar\/gki332","article-title":"The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma","volume":"33","author":"Chin","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2014.10.147_b0055","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1093\/nar\/29.10.2154","article-title":"CREB-H: a novel mammalian transcription factor belonging to the CREB\/ATF family and functioning via the box-B element with a liver-specific expression","volume":"29","author":"Omori","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2014.10.147_b0060","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nm.2347","article-title":"The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism","volume":"17","author":"Lee","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2014.10.147_b0065","doi-asserted-by":"crossref","first-page":"12737","DOI":"10.1073\/pnas.96.22.12737","article-title":"Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes","volume":"96","author":"Foretz","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2014.10.147_b0070","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00125-012-2771-2","article-title":"CAMP response element binding protein H mediates fenofibrate-induced suppression of hepatic lipogenesis","volume":"56","author":"Min","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2014.10.147_b0075","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.biocel.2011.06.010","article-title":"The roles of ER stress and P450 2E1 in CCl(4)-induced steatosis","volume":"43","author":"Lee","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2014.10.147_b0080","first-page":"829","article-title":"Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo","volume":"42","author":"Busse","year":"1992","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.bbrc.2014.10.147_b0085","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/biof.5520060303","article-title":"Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization","volume":"6","author":"Han","year":"1997","journal-title":"Biofactors"},{"key":"10.1016\/j.bbrc.2014.10.147_b0090","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1093\/carcin\/16.9.2099","article-title":"Uptake and distribution of N-acetylcysteine in mice: tissue-specific effects on glutathione concentrations","volume":"16","author":"McLellan","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbrc.2014.10.147_b0095","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1179\/135100005X21624","article-title":"Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex","volume":"10","author":"Suh","year":"2005","journal-title":"Redox Rep."},{"key":"10.1016\/j.bbrc.2014.10.147_b0100","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0006-2952(95)00116-H","article-title":"Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant?","volume":"50","author":"Ou","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2014.10.147_b0105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0014-4835(02)00307-X","article-title":"Alpha lipoic acid changes iron uptake and storage in lens epithelial cells","volume":"76","author":"Goralska","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbrc.2014.10.147_b0110","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00011-010-0256-7","article-title":"Evidence that alpha-lipoic acid inhibits NF-kappaB activation independent of its antioxidant function","volume":"60","author":"Ying","year":"2011","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbrc.2014.10.147_b0115","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.intimp.2007.10.020","article-title":"Alpha-lipoic acid inhibits TNF-alpha induced NF-kappa B activation through blocking of MEKK1-MKK4-IKK signaling cascades","volume":"8","author":"Lee","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2014.10.147_b0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mehy.2008.07.043","article-title":"The \u201crejuvenatory\u201d impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alpha","volume":"72","author":"McCarty","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.bbrc.2014.10.147_b0125","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1002\/hep.22496","article-title":"Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways","volume":"48","author":"Park","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2014.10.147_b0130","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1210\/en.2008-0816","article-title":"Fibroblast growth factor 21 corrects obesity in mice","volume":"149","author":"Coskun","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2014.10.147_b0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4093\/dmj.2012.36.1.26","article-title":"Fibroblast growth factor 21: a novel metabolic regulator","volume":"36","author":"Seo","year":"2012","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.bbrc.2014.10.147_b0140","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1210\/en.2009-0221","article-title":"Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity","volume":"150","author":"Berglund","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2014.10.147_b0145","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cmet.2013.08.005","article-title":"The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes","volume":"18","author":"Gaich","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2014.10.147_b0150","doi-asserted-by":"crossref","first-page":"e65763","DOI":"10.1371\/journal.pone.0065763","article-title":"LY2405319, an engineered FGF21 variant, improves the metabolic status of diabetic monkeys","volume":"8","author":"Adams","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2014.10.147_b0155","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cmet.2007.05.002","article-title":"Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states","volume":"5","author":"Badman","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2014.10.147_b0160","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bbrc.2007.06.068","article-title":"PPARalpha is a key regulator of hepatic FGF21","volume":"360","author":"Lundasen","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2014.10.147_b0165","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1440-1746.2006.04819.x","article-title":"PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes","volume":"23","author":"Seo","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2014.10.147_b0170","doi-asserted-by":"crossref","first-page":"465282","DOI":"10.1155\/2012\/465282","article-title":"Metformin stimulates FGF21 expression in primary hepatocytes","volume":"2012","author":"Nygaard","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.bbrc.2014.10.147_b0175","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbrc.2013.09.026","article-title":"Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation","volume":"440","author":"Kim","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2014.10.147_b0180","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nm1061","article-title":"Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase","volume":"10","author":"Kim","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2014.10.147_b0185","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.bbrc.2005.05.035","article-title":"Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle","volume":"332","author":"Lee","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2014.10.147_b0190","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.2174\/0929867321666140706141806","article-title":"Physiological effect and therapeutic application of alpha lipoic acid","volume":"21","author":"Park","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbrc.2014.10.147_b0195","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.abb.2009.01.024","article-title":"Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion","volume":"485","author":"Butler","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"issue":"85","key":"10.1016\/j.bbrc.2014.10.147_b0200","first-page":"e81","article-title":"Effects of alpha-lipoic acid on body weight in obese subjects","volume":"124","author":"Koh","year":"2011","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bbrc.2014.10.147_b0205","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2174\/187153009789839147","article-title":"A current update on the use of alpha lipoic acid in the management of type 2 diabetes mellitus","volume":"9","author":"Poh","year":"2009","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"issue":"Suppl. 2","key":"10.1016\/j.bbrc.2014.10.147_b0210","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/diab.46.2.S62","article-title":"Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy","volume":"46","author":"Ziegler","year":"1997","journal-title":"Diabetes"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14019767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14019767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T19:33:53Z","timestamp":1717529633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X14019767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":42,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0006291X14019767"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.10.147","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.10.147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}