{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T02:56:35Z","timestamp":1696560995391},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Health, Labor, and Welfare of Japan","award":["21591313"],"award-info":[{"award-number":["21591313"]}]},{"name":"Ministry of Health, Labor, and Welfare of Japan","award":["25282033"],"award-info":[{"award-number":["25282033"]}]},{"name":"Cancer Research Network"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.bbrc.2014.12.108","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T17:15:41Z","timestamp":1420650941000},"page":"318-323","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hedgehog signaling is synergistically enhanced by nutritional deprivation and ligand stimulation in human fibroblasts of Gorlin syndrome"],"prefix":"10.1016","volume":"457","author":[{"given":"Hiromi","family":"Mizuochi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Shiohama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Uchikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Shimojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2014.12.108_bib1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nrm3598","article-title":"The mechanisms of Hedgehog signalling and its roles in development and disease","volume":"14","author":"Briscoe","year":"2013","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2014.12.108_bib2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/287795a0","article-title":"Mutations affecting segment number and polarity in Drosophila","volume":"287","author":"Nusslein-Volhard","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2014.12.108_bib3","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1161\/STROKEAHA.109.561951","article-title":"Sonic hedgehog regulates ischemia\/hypoxia-induced neural progenitor proliferation","volume":"40","author":"Sims","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2014.12.108_bib4","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1242\/dev.083691","article-title":"Roles for Hedgehog signaling in adult organ homeostasis and repair","author":"Petrova","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2014.12.108_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2002906","article-title":"The Hedgehog signal transduction network","volume":"5","author":"Robbins","year":"2012","journal-title":"Sci. Signal"},{"key":"10.1016\/j.bbrc.2014.12.108_bib6","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1056\/NEJM196005052621803","article-title":"Multiple nevoid basal-cell epithelioma, jaw cysts and bifid rib. A syndrome","volume":"262","author":"Gorlin","year":"1960","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2014.12.108_bib7","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/ped.12461","article-title":"Gorlin syndrome (nevoid basal cell carcinoma syndrome): update and literature review","volume":"56","author":"Fujii","year":"2014","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.bbrc.2014.12.108_bib8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/(SICI)1096-8628(19970331)69:3<299::AID-AJMG16>3.0.CO;2-M","article-title":"Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome","volume":"69","author":"Kimonis","year":"1997","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.bbrc.2014.12.108_bib9","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1056\/NEJMoa0902903","article-title":"Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449","volume":"361","author":"Rudin","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2014.12.108_bib10","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1056\/NEJMoa1113538","article-title":"Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome","volume":"366","author":"Tang","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2014.12.108_bib11","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1056\/NEJMoa1113713","article-title":"Efficacy and safety of vismodegib in advanced basal-cell carcinoma","volume":"366","author":"Sekulic","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2014.12.108_bib12","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/ncb2345","article-title":"The centrosome cycle: centriole biogenesis, duplication and inherent asymmetries","volume":"13","author":"Nigg","year":"2011","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.bbrc.2014.12.108_bib13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/bbrc.1997.7603","article-title":"Abnormal DNA synthesis activity induced by X-rays in nevoid basal cell carcinoma syndrome cells","volume":"240","author":"Fujii","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2014.12.108_bib14","doi-asserted-by":"crossref","first-page":"e4818","DOI":"10.1371\/journal.pone.0004818","article-title":"PTCH1\u00a0+\/\u2212 dermal fibroblasts isolated from healthy skin of Gorlin syndrome patients exhibit features of carcinoma associated fibroblasts","volume":"4","author":"Valin","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2014.12.108_bib15","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrg2774","article-title":"The primary cilium: a signalling centre during vertebrate development","volume":"11","author":"Goetz","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbrc.2014.12.108_bib16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1126\/science.1139740","article-title":"Patched1 regulates hedgehog signaling at the primary cilium","volume":"317","author":"Rohatgi","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2014.12.108_bib17","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1083\/jcb.200706028","article-title":"Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery","volume":"180","author":"Kiprilov","year":"2008","journal-title":"J.\u00a0Cell. Biol."},{"key":"10.1016\/j.bbrc.2014.12.108_bib18","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1186\/1471-2407-12-571","article-title":"Starvation-induced activation of ATM\/Chk2\/p53 signaling sensitizes cancer cells to cisplatin","volume":"12","author":"Shi","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbrc.2014.12.108_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11060-011-0684-4","article-title":"Modulation of pediatric brain tumor autophagy and chemosensitivity","volume":"106","author":"Levy","year":"2012","journal-title":"J.\u00a0Neurooncol."},{"key":"10.1016\/j.bbrc.2014.12.108_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.mcn.2004.01.004","article-title":"The role of Zic genes in neural development","volume":"26","author":"Aruga","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbrc.2014.12.108_bib21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/dbio.2002.0598","article-title":"Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation","volume":"244","author":"Aruga","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbrc.2014.12.108_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1471-2407-10-79","article-title":"Expression of ZIC family genes in meningiomas and other brain tumors","volume":"10","author":"Aruga","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbrc.2014.12.108_bib23","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.1074\/jbc.C000773200","article-title":"Physical and functional interactions between Zic and Gli proteins","volume":"276","author":"Koyabu","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2014.12.108_bib24","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1074\/jbc.M004430200","article-title":"Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins","volume":"276","author":"Mizugishi","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2014.12.108_bib25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gendis.2014.07.005","article-title":"Bone morphogenetic protein (BMP) signaling in development and human diseases","volume":"1","author":"Wang","year":"2014","journal-title":"Genes. Dis."},{"key":"10.1016\/j.bbrc.2014.12.108_bib26","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nature05349","article-title":"Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells","volume":"444","author":"Piccirillo","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2014.12.108_bib27","doi-asserted-by":"crossref","first-page":"10114","DOI":"10.1073\/pnas.89.21.10114","article-title":"Telomere length predicts replicative capacity of human fibroblasts","volume":"89","author":"Allsopp","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.bbrc.2014.12.108_bib28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0047-6374(00)00173-1","article-title":"Telomere length in different tissues of elderly patients","volume":"119","author":"Friedrich","year":"2000","journal-title":"Mech. Ageing Dev."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14023225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14023225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T12:53:54Z","timestamp":1537966434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X14023225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0006291X14023225"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.12.108","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hedgehog signaling is synergistically enhanced by nutritional deprivation and ligand stimulation in human fibroblasts of Gorlin syndrome","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.12.108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}