{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:30:42Z","timestamp":1771338642285,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS053588"],"award-info":[{"award-number":["NS053588"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS087149"],"award-info":[{"award-number":["NS087149"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.bbrc.2015.01.039","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T16:31:28Z","timestamp":1421685088000},"page":"635-639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation"],"prefix":"10.1016","volume":"457","author":[{"given":"Natalia S.","family":"Rozas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Redell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"James","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony N.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Gambello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramod K.","family":"Dash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2015.01.039_bib1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1468-1331.2009.02567.x","article-title":"Prevalence of subependymal giant cell tumors in patients with tuberous sclerosis and a review of the literature","volume":"16","author":"Adriaensen","year":"2009","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.bbrc.2015.01.039_bib2","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1016\/j.cellsig.2014.04.019","article-title":"Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids","volume":"26","author":"Averous","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.bbrc.2015.01.039_bib3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.tcb.2014.03.003","article-title":"Regulation of mTORC1 by amino acids","volume":"24","author":"Bar-Peled","year":"2014","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.bbrc.2015.01.039_bib4","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1083\/jcb.201306041","article-title":"Where is mTOR and what is it doing there?","volume":"203","author":"Betz","year":"2013","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2015.01.039_bib5","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/jnen\/63.12.1236","article-title":"Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation","volume":"63","author":"Chan","year":"2004","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbrc.2015.01.039_bib6","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1007\/s00726-012-1312-0","article-title":"Glutamine stimulates mTORC1 independent of the cell content of essential amino acids","volume":"43","author":"Chiu","year":"2012","journal-title":"Amino. Acids"},{"key":"10.1016\/j.bbrc.2015.01.039_bib7","doi-asserted-by":"crossref","first-page":"374","DOI":"10.4161\/oxim.3.6.14787","article-title":"Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders","volume":"3","author":"Chong","year":"2010","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.bbrc.2015.01.039_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00401-013-1085-x","article-title":"Evolving neurobiology of tuberous sclerosis complex","volume":"125","author":"Crino","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbrc.2015.01.039_bib9","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2174\/1570159X11209040404","article-title":"mTOR inhibitors in tuberous sclerosis complex","volume":"10","author":"Curatolo","year":"2012","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.bbrc.2015.01.039_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2165\/11207730-000000000-00000","article-title":"Everolimus: in patients with subependymal giant cell astrocytoma associated with tuberous sclerosis complex","volume":"14","author":"Curran","year":"2012","journal-title":"Paediatr. Drugs"},{"key":"10.1016\/j.bbrc.2015.01.039_bib11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1086\/316951","article-title":"Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs","volume":"68","author":"Dabora","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2015.01.039_bib12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00726-007-0607-z","article-title":"Antagonistic effects of leucine and glutamine on the mTOR pathway in myogenic C2C12 cells","volume":"35","author":"Deldicque","year":"2008","journal-title":"Amino. Acids"},{"key":"10.1016\/j.bbrc.2015.01.039_bib13","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nm1788","article-title":"Reversal of learning deficits in a Tsc2+\/- mouse model of tuberous sclerosis","volume":"14","author":"Ehninger","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2015.01.039_bib14","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.ijdevneu.2013.02.008","article-title":"A\u00a0circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits","volume":"31","author":"Feliciano","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbrc.2015.01.039_bib15","first-page":"486402","article-title":"Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders","author":"Gipson","year":"2012","journal-title":"Neural. Plast."},{"key":"10.1016\/j.bbrc.2015.01.039_bib16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.febslet.2011.02.001","article-title":"TSC1\/TSC2 signaling in the CNS","volume":"585","author":"Han","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2015.01.039_bib17","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/978-3-642-54490-3_23","article-title":"Everolimus","volume":"201","author":"Hasskarl","year":"2014","journal-title":"Recent Results Cancer Res."},{"key":"10.1016\/j.bbrc.2015.01.039_bib18","first-page":"1639","article-title":"Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors","volume":"151","author":"Henske","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2015.01.039_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/dvg.20271","article-title":"Generation of a conditional disruption of the Tsc2 gene","volume":"45","author":"Hernandez","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.bbrc.2015.01.039_bib20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/BJ20080281","article-title":"The TSC1-TSC2 complex: a molecular switchboard controlling cell growth","volume":"412","author":"Huang","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2015.01.039_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.semcdb.2014.09.011","article-title":"Growing knowledge of the mTOR signaling network","volume":"36","author":"Huang","year":"2014","journal-title":"Semin. Cell. Dev. Biol."},{"key":"10.1016\/j.bbrc.2015.01.039_bib22","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","article-title":"Rheb GTPase is a direct target of TSC2 GAP\u00a0activity and regulates mTOR signaling","volume":"17","author":"Inoki","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2015.01.039_bib23","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1086\/302381","article-title":"Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis","volume":"64","author":"Jones","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2015.01.039_bib24","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.pediatrneurol.2013.12.002","article-title":"Mechanism-based treatment in tuberous sclerosis complex","volume":"50","author":"Julich","year":"2014","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.bbrc.2015.01.039_bib25","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.celrep.2014.04.048","article-title":"Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases","volume":"7","author":"Kassai","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2015.01.039_bib26","first-page":"1206","article-title":"Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice","volume":"59","author":"Kobayashi","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2015.01.039_bib27","doi-asserted-by":"crossref","first-page":"8762","DOI":"10.1073\/pnas.151033798","article-title":"A\u00a0germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice","volume":"98","author":"Kobayashi","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2015.01.039_bib28","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1212\/WNL.0b013e3182815428","article-title":"Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma","volume":"80","author":"Krueger","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2015.01.039_bib29","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1242\/jcs.051011","article-title":"mTOR signaling at a glance","volume":"122","author":"Laplante","year":"2009","journal-title":"J.\u00a0Cell. Sci."},{"key":"10.1016\/j.bbrc.2015.01.039_bib30","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2015.01.039_bib31","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cub.2005.02.053","article-title":"Rheb binds and regulates the mTOR kinase","volume":"15","author":"Long","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2015.01.039_bib32","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2013.11.049","article-title":"Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome","volume":"156","author":"Menon","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2015.01.039_bib33","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbrc.2004.11.015","article-title":"Glutamine is a key regulator for amino acid-controlled cell growth through the mTOR signaling pathway in rat intestinal epithelial cells","volume":"326","author":"Nakajo","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.01.039_bib34","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2008.11.044","article-title":"Bidirectional transport of amino acids regulates mTOR and autophagy","volume":"136","author":"Nicklin","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2015.01.039_bib35","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnmol.2014.00028","article-title":"mTOR signaling and its roles in normal and abnormal brain development","volume":"7","author":"Takei","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbrc.2015.01.039_bib36","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0960-9822(03)00506-2","article-title":"Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb","volume":"13","author":"Tee","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2015.01.039_bib37","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ana.10283","article-title":"Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures","volume":"52","author":"Uhlmann","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbrc.2015.01.039_bib38","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/hmg\/ddp025","article-title":"Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse","volume":"18","author":"Way","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2015.01.039_bib39","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1093\/hmg\/dds156","article-title":"The differential effects of prenatal and\/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex","volume":"21","author":"Way","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2015.01.039_bib40","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1182\/blood-2013-03-493163","article-title":"Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia","volume":"122","author":"Willems","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2015.01.039_bib41","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1586\/ern.13.48","article-title":"A\u00a0critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials","volume":"13","author":"Wong","year":"2013","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.bbrc.2015.01.039_bib42","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4103\/2319-4170.110365","article-title":"Mammalian target of rapamycin (mTOR) pathways in neurological diseases","volume":"36","author":"Wong","year":"2013","journal-title":"Biomed. J."},{"key":"10.1016\/j.bbrc.2015.01.039_bib43","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1007\/s00726-011-1060-6","article-title":"Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells","volume":"42","author":"Yao","year":"2012","journal-title":"Amino. Acids"},{"key":"10.1016\/j.bbrc.2015.01.039_bib44","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/hmg\/ddq491","article-title":"Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex","volume":"20","author":"Zeng","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2015.01.039_bib45","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1207056","article-title":"mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase","volume":"334","author":"Zoncu","year":"2011","journal-title":"Science"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15000613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15000613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T07:00:08Z","timestamp":1537945208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X15000613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0006291X15000613"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.01.039","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.01.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}