{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:52:52Z","timestamp":1758048772836,"version":"3.44.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003993","name":"Ministry of Agriculture, Forestry and Fisheries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003993","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.bbrc.2015.01.049","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T17:47:32Z","timestamp":1422294452000},"page":"28-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti-WASP intrabodies inhibit inflammatory responses induced by\u00a0Toll-like receptors 3, 7, and 9, in macrophages"],"prefix":"10.1016","volume":"458","author":[{"given":"Chisato","family":"Sakuma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takato","family":"Takenouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2015.01.049_bib1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0092-8674(94)90528-2","article-title":"Isolation of a novel gene mutation in Wiskott-Aldrich syndrome","volume":"78","author":"Derry","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2015.01.049_bib2","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.4049\/jimmunol.161.2.1026","article-title":"Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl phenylalanine","volume":"161","author":"Badolato","year":"1998","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib3","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1046\/j.1365-2141.1998.00767.x","article-title":"Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome","volume":"101","author":"Zicha","year":"1998","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib4","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1182\/blood.V95.9.2943.009k17_2943_2946","article-title":"Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis","volume":"95","author":"Lorenzi","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2015.01.049_bib5","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1182\/blood-2003-05-1592","article-title":"Mutations of the Wiskott-Aldrich syndrome protein (WASP): hotspots, effect on transcription, and translation and phenotype\/genotype correlation","volume":"104","author":"Jin","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2015.01.049_bib6","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.4049\/jimmunol.167.8.4701","article-title":"Overexpression of the Wiskott-Aldrich syndrome protein N-terminal domain in transgenic mice inhibits T cell proliferative response via TCR signaling without affecting cytoskeletal rearrangements","volume":"167","author":"Sato","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib7","doi-asserted-by":"crossref","first-page":"e30351","DOI":"10.1371\/journal.pone.0030351","article-title":"Critical roles of the WASP N-terminal domain and Btk in LPS-induced inflammatory response in macrophages","volume":"7","author":"Sakuma","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2015.01.049_bib8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbrc.2012.05.105","article-title":"Single-chain variable fragment intrabody impairs LPS-induced inflammatory responses by interfering with the interaction between the WASP N-terminal domain and Btk in macrophages","volume":"423","author":"Sakuma","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.01.049_bib9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.molimm.2014.08.004","article-title":"Specific binding of the WASP N-terminal domain to Btk is critical for TLR2 signaling in macroophages","volume":"63","author":"Sakuma","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib10","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1073\/pnas.1119238109","article-title":"Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral responses","volume":"109","author":"Lee","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.bbrc.2015.01.049_bib11","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.4049\/jimmunol.1300057","article-title":"Bruton's tyrosine kinase is required for apoptotic cell uptake via regulating the phosphorylation and localization of calreticulin","volume":"190","author":"Byrne","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib12","doi-asserted-by":"crossref","first-page":"36953","DOI":"10.1074\/jbc.M707682200","article-title":"Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase","volume":"282","author":"Doyle","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2015.01.049_bib13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of Toll-like receptors\u00a0\u2212 redefining innate immunity","volume":"13","author":"O'Neill","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib15","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-strand RNA and activation of NF-\u03baB by Toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2015.01.049_bib16","doi-asserted-by":"crossref","first-page":"6646","DOI":"10.1073\/pnas.0631696100","article-title":"Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7","volume":"100","author":"Lee","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.bbrc.2015.01.049_bib17","doi-asserted-by":"crossref","first-page":"9237","DOI":"10.1073\/pnas.161293498","article-title":"Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition","volume":"98","author":"Bauer","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.bbrc.2015.01.049_bib18","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.4049\/jimmunol.178.4.2380","article-title":"RICK\/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs","volume":"178","author":"Park","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1443.020","article-title":"Toll-like receptor and RIG-1-like receptor signaling","volume":"1143","author":"Kawai","year":"2008","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.bbrc.2015.01.049_bib20","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/ni758","article-title":"Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway","volume":"3","author":"Hemmi","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib21","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.4049\/jimmunol.171.8.3977","article-title":"Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand","volume":"171","author":"Nagase","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib22","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.4049\/jimmunol.168.9.4711","article-title":"Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: central role of extracellular signaling-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response","volume":"168","author":"Yi","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1600-065X.2000.imr017504.x","article-title":"The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective","volume":"175","author":"Satterthwaite","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbrc.2015.01.049_bib24","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/ni0901-835","article-title":"TIRAP: an adaptor molecule in the Toll signaling pathway","volume":"2","author":"Horng","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature01180","article-title":"The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors","volume":"420","author":"Horng","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2015.01.049_bib26","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nature01182","article-title":"Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4","volume":"420","author":"Yamamoto","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2015.01.049_bib27","doi-asserted-by":"crossref","first-page":"10489","DOI":"10.1074\/jbc.M508892200","article-title":"MyD88 adaptor-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction","volume":"281","author":"Gray","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2015.01.049_bib28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling","volume":"7","author":"O'Neill","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2015.01.049_bib29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1124\/pr.109.001073","article-title":"Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer","volume":"61","author":"O'Neill","year":"2009","journal-title":"Pharmacol. Rev."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15000790?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15000790?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:11:43Z","timestamp":1757761903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X15000790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0006291X15000790"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.01.049","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-WASP intrabodies inhibit inflammatory responses induced by\u00a0Toll-like receptors 3, 7, and 9, in macrophages","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.01.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}