{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:17:21Z","timestamp":1787170641159,"version":"build-2736575974"},"reference-count":14,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Telethon-Italy","award":["GUP09004"],"award-info":[{"award-number":["GUP09004"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.bbrc.2015.01.157","type":"journal-article","created":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T20:35:44Z","timestamp":1423600544000},"page":"601-604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Early onset cardiomyopathy associated with the mitochondrial tRNALeu(UUR) 3271T&gt;C MELAS mutation"],"prefix":"10.1016","volume":"458","author":[{"given":"Giacomo","family":"Brisca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fiorillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Nesti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Trucco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Derchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Andaloro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Assereto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Morcaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Pedemonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Minetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo M.","family":"Santorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2015.01.157_bib1","first-page":"9","article-title":"Cardiological manifestations of mitochondrial respiratory chain disorders","volume":"30","author":"Berardo","year":"2011","journal-title":"Acta Myol."},{"key":"10.1016\/j.bbrc.2015.01.157_bib2","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/nrg3275","article-title":"Human mitochondrial DNA: roles of inherited and somatic mutations","volume":"13","author":"Schon","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbrc.2015.01.157_bib3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1177\/08830738050200022301","article-title":"Clinical and genetic features in two families with MELAS and the T3271C mutation in mitochondrial DNA","volume":"20","author":"Tay","year":"2005","journal-title":"J.\u00a0Child. Neurol."},{"key":"10.1016\/j.bbrc.2015.01.157_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/(SICI)1097-4598(199801)21:1<25::AID-MUS4>3.0.CO;2-I","article-title":"Clinical, physiological, and histological features in a kindred with the T3271C MELAS mutation","volume":"21","author":"Tarnopolsky","year":"1998","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.bbrc.2015.01.157_bib5","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0925-4439(91)90042-8","article-title":"A\u00a0new mtDNA mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)","volume":"1097","author":"Goto","year":"1991","journal-title":"Biochim. Bioph. Acta"},{"key":"10.1016\/j.bbrc.2015.01.157_bib6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1006\/bmmb.1994.1045","article-title":"A\u00a0Caucasian family with the 3271 mutation in mtDN","volume":"52","author":"Marie","year":"1994","journal-title":"Biochem. Med. Metab. Biol."},{"key":"10.1016\/j.bbrc.2015.01.157_bib7","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.2337\/diacare.19.11.1304","article-title":"Clinical picture of a case of diabetes mellitus with mitochondrial tRNA mutation at position 3271","volume":"119","author":"Suzuki","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbrc.2015.01.157_bib8","doi-asserted-by":"crossref","unstructured":"T. Nagashima, H. Kato, S. Maguchi, et\u00a0al, A mitochondrial encephalo-myo-neuropathy with a nucleotide position 3271 (T-C) point mutation in the mitochondrial DNA. Neuromusc. Disord.. 11(200) 470\u2013476.","DOI":"10.1016\/S0960-8966(01)00190-0"},{"key":"10.1016\/j.bbrc.2015.01.157_bib9","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ajmg.a.31041","article-title":"Mitochondrial mutation in a child with distal arthrogryposis","volume":"140","author":"McPherson","year":"2006","journal-title":"Am. J. Gen."},{"key":"10.1016\/j.bbrc.2015.01.157_bib10","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1002\/mus.880181422","article-title":"Clinical features of MELAS and mitochondrial DNA mutations","volume":"3","author":"Goto","year":"1995","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.bbrc.2015.01.157_bib11","first-page":"561","article-title":"A\u00a0patient of MELAS with 3271 mutation with fatal outcome after alcohol intake","volume":"40","author":"Shinde","year":"2000","journal-title":"Rinsho Shinkeigaku"},{"key":"10.1016\/j.bbrc.2015.01.157_bib12","first-page":"37","article-title":"Spinal dysraphism associated with congenital heart disorder in a girl with MELAS syndrome and point mutation at mtDNA nucleotide 3271","volume":"43","author":"Barisic","year":"2002","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.bbrc.2015.01.157_bib13","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1203\/01.PDR.0000169966.82325.1A","article-title":"A\u00a0juvenile case of MELAS with T3271C mitochondrial DNA mutation,","volume":"58","author":"Stenquvist","year":"2005","journal-title":"Ped. Res."},{"key":"10.1016\/j.bbrc.2015.01.157_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pediatrneurol.2007.09.015","article-title":"Clinical and genetic features in a MELAS child with a 3271T>C mutation","volume":"38","author":"Chou","year":"2008","journal-title":"Pediatr. Neurol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15002235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15002235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T16:46:56Z","timestamp":1566319616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X15002235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0006291X15002235"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.01.157","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early onset cardiomyopathy associated with the mitochondrial tRNALeu(UUR) 3271T>C MELAS mutation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.01.157","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}