{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:35:24Z","timestamp":1762094124401,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201470","81372069","81171811"],"award-info":[{"award-number":["81201470","81372069","81171811"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.bbrc.2015.02.061","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T00:30:20Z","timestamp":1424392220000},"page":"49-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Peroxisome proliferator-activated receptor-\u03b3 (PPAR-\u03b3) agonist inhibits collagen synthesis in human hypertrophic scar fibroblasts by targeting Smad3 via miR-145"],"prefix":"10.1016","volume":"459","author":[{"given":"Hua-Yu","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Lin","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Tao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong-Xiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Hai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2015.02.061_bib1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbrc.2014.09.077","article-title":"Acute downregulation of miR-155 at wound sites leads to a reduced fibrosis through attenuating inflammatory response","volume":"1","author":"Yang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.02.061_bib2","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/jid.2012.499","article-title":"The IL-6 trans-signaling-STAT3 pathway mediates ECM and cellular proliferation in fibroblasts from hypertrophic scar","volume":"5","author":"Ray","year":"2013","journal-title":"J.\u00a0Invest. Dermatol"},{"key":"10.1016\/j.bbrc.2015.02.061_bib3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3892\/ijmm.2014.1912","article-title":"Effects of integrin \u03b1v\u03b23 on differentiation and collagen synthesis induced by connective tissue growth factor in human hypertrophic scar fibroblasts","volume":"5","author":"Hu","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbrc.2015.02.061_bib4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00403-013-1334-9","article-title":"The role of ERK and JNK signaling in connective tissue growth factor induced extracellular matrix protein production and scar formation","volume":"5","author":"Hu","year":"2013","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.bbrc.2015.02.061_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1749-6632.1999.tb07955.x","article-title":"Pathophysiology and treatment of fibroproliferative disorders following thermal injury","volume":"888","author":"Tredget","year":"1999","journal-title":"Ann. N Y Acad. Sci."},{"issue":"443","key":"10.1016\/j.bbrc.2015.02.061_bib6","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bbrc.2013.11.129","article-title":"PPAR-\u03b3 agonist stabilizes KLF4 protein via activating Akt signaling and reducing KLF4 ubiquitination","volume":"10","author":"Sun","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.02.061_bib7","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1365-2133.2008.08989.x","article-title":"Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts","volume":"4","author":"Zhang","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.bbrc.2015.02.061_bib8","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.bjps.2009.06.032","article-title":"Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist inhibits transforming growth factor-beta1 and matrix production in human dermal fibroblasts","volume":"7","author":"Zhang","year":"2010","journal-title":"J.\u00a0Plast. Reconstr. Aesthet. Surg."},{"key":"10.1016\/j.bbrc.2015.02.061_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbrc.2014.01.010","article-title":"Inhibitory role of Id1 on TGF-\u03b2-induced collagen expression in human dermal fibroblasts","volume":"1","author":"Je","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.02.061_bib10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.radonc.2004.01.010","article-title":"Smad-3 and Smad-7 expression following anti-transforming growth factor beta 1 (TGF-beta1)-treatment in irradiated rat tissue","volume":"3","author":"Schultze-Mosgau","year":"2004","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.bbrc.2015.02.061_bib11","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/labinvest.2014.43","article-title":"Smad3 signaling activates bone marrow-derived fibroblasts in renal fibrosis","volume":"5","author":"Chen","year":"2014","journal-title":"Lab. Invest"},{"key":"10.1016\/j.bbrc.2015.02.061_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2362.2008.02076.x","article-title":"Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectalfibrosis","volume":"2","author":"Latella","year":"2009","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2015.02.061_bib13","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1016\/j.ajpath.2014.04.014","article-title":"Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in\u00a0vivo and in\u00a0vitro","volume":"8","author":"Duan","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2015.02.061_bib14","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s10753-014-0031-y","article-title":"NS5ATP9 suppresses activation of human hepatic stellate cells, possibly via inhibition of Smad3\/Phosphorylated-Smad3 expression","volume":"38","author":"Zhang","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.bbrc.2015.02.061_bib15","first-page":"2645","article-title":"Dexamethasone attenuates bleomycin-induced lung fibrosis in mice through TGF-\u03b2, Smad3, and JAK-STAT pathway","volume":"9","author":"Shi","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.bbrc.2015.02.061_bib16","doi-asserted-by":"crossref","first-page":"e97114","DOI":"10.1371\/journal.pone.0097114","article-title":"MicroRNA-21 regulates hTERT via PTEN in hypertrophic scar fibroblasts","volume":"5","author":"Zhu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2015.02.061_bib17","doi-asserted-by":"crossref","first-page":"29001","DOI":"10.1074\/jbc.M114.600783","article-title":"Transforming growth factor-1 (TGF-\u03b21) enhances expression of profibrotic genes through a novel signaling cascade and MicroRNAs in renal mesangial cells","volume":"42","author":"Castro","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2015.02.061_bib18","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.bbamcr.2014.03.003","article-title":"Peroxisome proliferator-activated receptor \u03b3-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer","volume":"6","author":"Panza","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2015.02.061_bib19","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s005950200049","article-title":"Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone","volume":"4","author":"Sunami","year":"2002","journal-title":"Surg. Today"},{"key":"10.1016\/j.bbrc.2015.02.061_bib20","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.3892\/mmr.2013.1309","article-title":"Pioglitazone inhibits high glucose-induced synthesis of extracellular matrix by NF-\u03baB and AP-1 pathways in rat peritoneal mesothelial cells","volume":"4","author":"Zhou","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbrc.2015.02.061_bib21","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/jor.21235","article-title":"Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing","volume":"5","author":"Katzel","year":"2011","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.bbrc.2015.02.061_bib22","article-title":"MicroRNA-29b regulates TGF-\u03b21-mediated epithelial-mesenchymal transition of retinal pigment epithelial cells by targeting AKT2","author":"Li","year":"2014","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.bbrc.2015.02.061_bib23","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/gtc.12166","article-title":"Suppression of the TGF-\u03b21-induced protein expression of SNAI1 and N-cadherin by miR-199a","volume":"9","author":"Suzuki","year":"2014","journal-title":"Genes. Cells"},{"key":"10.1016\/j.bbrc.2015.02.061_bib24","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bbrc.2014.08.035","article-title":"NF kappaB activation is essential for miR-21 induction by TGF-\u03b21 in high glucose conditions","volume":"4","author":"Madhyastha","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.02.061_bib25","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/j.1582-4934.2011.01385.x","article-title":"miR-145 is differentially regulated by TGF-\u03b21 and is chaemia and targets Disabled-2 expression and wnt\/\u03b2-catenin activity","volume":"5","author":"Mayorga","year":"2012","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.bbrc.2015.02.061_bib26","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bbrc.2012.03.075","article-title":"MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting \u03b2-catenin","volume":"4","author":"Sun","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.02.061_bib27","doi-asserted-by":"crossref","first-page":"e21679","DOI":"10.1371\/journal.pone.0021679","article-title":"MicroRNA-145 regulates chondrogenic differentiation of mesenchymal stem cells by targeting Sox9","volume":"7","author":"Yang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2015.02.061_bib28","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1074\/jbc.M111.302430","article-title":"Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145)","volume":"2","author":"Martinez-Sanchez","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2015.02.061_bib29","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1038\/onc.2012.468","article-title":"miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells","volume":"39","author":"Kliese","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2015.02.061_bib30","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1096\/fj.12-219493","article-title":"miR-145 regulates myofibroblast differentiation and lung fibrosis","volume":"6","author":"Yang","year":"2013","journal-title":"FASEB J."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15002892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15002892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:30:28Z","timestamp":1762093828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X15002892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0006291X15002892"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.02.061","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peroxisome proliferator-activated receptor-\u03b3 (PPAR-\u03b3) agonist inhibits collagen synthesis in human hypertrophic scar fibroblasts by targeting Smad3 via miR-145","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.02.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}