{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:12:55Z","timestamp":1790327575250,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Major National Basic Research Program","award":["2011CB503900"],"award-info":[{"award-number":["2011CB503900"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["30821001"],"award-info":[{"award-number":["30821001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["30930037"],"award-info":[{"award-number":["30930037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.bbrc.2015.02.147","type":"journal-article","created":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T07:49:52Z","timestamp":1425714592000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Expression of seipin in adipose tissue rescues lipodystrophy, hepatic steatosis and insulin resistance in seipin null mice"],"prefix":"10.1016","volume":"460","author":[{"given":"Mingming","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2015.02.147_bib1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0163-7827(94)00006-8","article-title":"Heterogeneity in adipose tissue metabolism: causes, implications and management of regional adiposity","volume":"34","author":"Abate","year":"1995","journal-title":"Prog. Lipid Res."},{"issue":"Suppl.\u00a04","key":"10.1016\/j.bbrc.2015.02.147_bib2","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/S1098-3597(06)80039-6","article-title":"Adipose tissue dysfunction in obesity and lipodystrophy","volume":"8","author":"Garg","year":"2006","journal-title":"Clin. Cornerstone"},{"key":"10.1016\/j.bbrc.2015.02.147_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng585","article-title":"Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13","volume":"28","author":"Magre","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2015.02.147_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/ng1313","article-title":"Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and silver syndrome","volume":"36","author":"Windpassinger","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2015.02.147_bib5","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1093\/hmg\/ddu126","article-title":"Lack of seipin in neurons results in anxiety- and depression-like behaviors via down regulation of PPARgamma","volume":"23","author":"Zhou","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2015.02.147_bib6","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.1073\/pnas.1324025111","article-title":"Lack of testicular seipin causes teratozoospermia syndrome in men","volume":"111","author":"Jiang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2015.02.147_bib7","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.2337\/db08-0184","article-title":"The human lipodystrophy gene BSCL2\/seipin may be essential for normal adipocyte differentiation","volume":"57","author":"Payne","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2015.02.147_bib8","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1210\/en.2009-0236","article-title":"The human lipodystrophy gene product BSCL2\/Seipin plays a key role in adipocyte differentiation","volume":"150","author":"Chen","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2015.02.147_bib9","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1128\/MCB.06465-11","article-title":"Berardinelli-seip congenital lipodystrophy 2\/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation","volume":"32","author":"Chen","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2015.02.147_bib10","doi-asserted-by":"crossref","first-page":"E705","DOI":"10.1152\/ajpendo.00237.2011","article-title":"Overexpression of a short human seipin\/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy","volume":"302","author":"Cui","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2015.02.147_bib11","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.2337\/db13-0729","article-title":"Adipose-specific knockout of Seipin\/Bscl2 results in progressive lipodystrophy","volume":"63","author":"Liu","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2015.02.147_bib12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.200711136","article-title":"Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast","volume":"180","author":"Fei","year":"2008","journal-title":"J.\u00a0Cell. Biol."},{"key":"10.1016\/j.bbrc.2015.02.147_bib13","doi-asserted-by":"crossref","first-page":"20890","DOI":"10.1073\/pnas.0704154104","article-title":"The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology","volume":"104","author":"Szymanski","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2015.02.147_bib14","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cmet.2014.03.028","article-title":"Seipin promotes adipose tissue fat storage through the ER Ca(2+)-ATPase SERCA","volume":"19","author":"Bi","year":"2014","journal-title":"Cell. Metab."},{"key":"10.1016\/j.bbrc.2015.02.147_bib15","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/hmg\/ddr205","article-title":"Seipin ablation in mice results in severe generalized lipodystrophy","volume":"20","author":"Cui","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2015.02.147_bib16","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/3327","article-title":"Real-time quantitative RT-PCR after laser-assisted cell picking","volume":"4","author":"Fink","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2015.02.147_bib17","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A\u00a0simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2015.02.147_bib18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ddmod.2007.10.003","article-title":"Mouse models of lipodystrophy key reagents for the understanding of the metabolic syndrome","volume":"4","author":"Asterholm","year":"2007","journal-title":"Drug Discov. Today Dis. Models"},{"key":"10.1016\/j.bbrc.2015.02.147_bib19","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1101\/gad.12.20.3168","article-title":"Life without white fat: a transgenic mouse","volume":"12","author":"Moitra","year":"1998","journal-title":"Genes. Dev."},{"key":"10.1016\/j.bbrc.2015.02.147_bib20","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1101\/gad.12.20.3182","article-title":"Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy","volume":"12","author":"Shimomura","year":"1998","journal-title":"Genes. Dev."},{"key":"10.1016\/j.bbrc.2015.02.147_bib21","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1177\/0300985810383870","article-title":"Pathology of congenital generalized lipodystrophy in Agpat2-\/- mice","volume":"48","author":"Vogel","year":"2011","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.bbrc.2015.02.147_bib22","doi-asserted-by":"crossref","first-page":"15712","DOI":"10.1073\/pnas.2536828100","article-title":"Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle","volume":"100","author":"He","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2015.02.147_bib23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1172\/JCI7901","article-title":"Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice","volume":"105","author":"Gavrilova","year":"2000","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.bbrc.2015.02.147_bib24","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.2337\/diabetes.51.9.2727","article-title":"Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy","volume":"51","author":"Colombo","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2015.02.147_bib25","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.bbalip.2011.11.010","article-title":"Pathophysiology of hypertriglyceridemia","volume":"1821","author":"Hassing","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2015.02.147_bib26","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s00125-013-2926-9","article-title":"Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2\/seipin-deficient mice","volume":"56","author":"Prieur","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2015.02.147_bib27","doi-asserted-by":"crossref","first-page":"37676","DOI":"10.1074\/jbc.M111.250449","article-title":"Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-\/-) gene lipodystrophic mice","volume":"286","author":"Agarwal","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2015.02.147_bib28","first-page":"en20141292","article-title":"Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2\/Seipin-deficient mice","author":"Chen","year":"2014","journal-title":"Endocrinology"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15003940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15003940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T17:07:51Z","timestamp":1651424871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X15003940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0006291X15003940"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.02.147","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of seipin in adipose tissue rescues lipodystrophy, hepatic steatosis and insulin resistance in seipin null mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.02.147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}