{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:46:16Z","timestamp":1791218776411,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["26893144"],"award-info":[{"award-number":["26893144"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.bbrc.2015.06.147","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T21:38:40Z","timestamp":1435181920000},"page":"299-305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Trophic factors from adipose tissue-derived multi-lineage progenitor cells promote cytodifferentiation of periodontal ligament cells"],"prefix":"10.1016","volume":"464","author":[{"given":"Keigo","family":"Sawada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Takedachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ozasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Iwayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Man","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanayuki","family":"Okura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2015.06.147_bib1","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1902\/jop.2005.76.12.2205","article-title":"Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial","volume":"76","author":"Nevins","year":"2005","journal-title":"J.\u00a0Periodontol."},{"key":"10.1016\/j.bbrc.2015.06.147_bib2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/0022034510384616","article-title":"FGF-2 stimulates periodontal regeneration: results of a multi-center randomized clinical trial","volume":"90","author":"Kitamura","year":"2011","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.bbrc.2015.06.147_bib3","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1089\/ten.tea.2008.0562","article-title":"Loss of proliferation and differentiation capacity of aged human periodontal ligament stem cells and rejuvenation by exposure to the young extrinsic environment","volume":"15","author":"Zheng","year":"2009","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.bbrc.2015.06.147_bib4","first-page":"363","article-title":"A\u00a0novel approach to periodontal tissue regeneration with mesenchymal stem cells and platelet-rich plasma using tissue engineering technology: A clinical case report","volume":"26","author":"Yamada","year":"2006","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"10.1016\/j.bbrc.2015.06.147_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1601-0825.2009.01593.x","article-title":"Utility of PDL progenitors for in\u00a0vivo tissue regeneration: a report of 3 cases","volume":"16","author":"Feng","year":"2010","journal-title":"Oral Dis."},{"key":"10.1016\/j.bbrc.2015.06.147_bib6","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1902\/jop.2008.070518","article-title":"Tissue-engineered cultured periosteum used with platelet-rich plasma and hydroxyapatite in treating human osseous defects","volume":"79","author":"Yamamiya","year":"2008","journal-title":"J.\u00a0Periodontol."},{"key":"10.1016\/j.bbrc.2015.06.147_bib7","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/jcb.20681","article-title":"Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow","volume":"97","author":"Mareschi","year":"2006","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.bbrc.2015.06.147_bib8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00441-011-1306-3","article-title":"Comparative investigation of the differentiation capability of bone-marrow- and adipose-derived mesenchymal stem cells by qualitative and quantitative analysis","volume":"347","author":"Vishnubalaji","year":"2012","journal-title":"Cell. Tissue Res."},{"key":"10.1016\/j.bbrc.2015.06.147_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3727\/096368912X655019","article-title":"Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats","volume":"22","author":"Katsuno","year":"2013","journal-title":"Cell. Transpl."},{"key":"10.1016\/j.bbrc.2015.06.147_bib10","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1634\/stemcells.2005-0342","article-title":"Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue","volume":"24","author":"Kern","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbrc.2015.06.147_bib11","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1042\/CBI20110618","article-title":"Characterization of in\u00a0vitro cultured bone marrow and adipose tissue-derived mesenchymal stem cells and their ability to express neurotrophic factors","volume":"36","author":"Taghi","year":"2012","journal-title":"Cell. Biol. Int."},{"key":"10.1016\/j.bbrc.2015.06.147_bib12","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1253\/circj.CJ-11-0246","article-title":"Gene and protein expression analysis of mesenchymal stem cells derived from rat adipose tissue and bone marrow","volume":"75","author":"Nakanishi","year":"2011","journal-title":"Circ. J."},{"key":"10.1016\/j.bbrc.2015.06.147_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2492\/inflammregen.34.109","article-title":"Periodontal tissue regeneration by transplantation of adipose tissue-derived multi-lineage progenitor cells","volume":"34","author":"Ozasa","year":"2014","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.bbrc.2015.06.147_bib14","doi-asserted-by":"crossref","first-page":"e1886","DOI":"10.1371\/journal.pone.0001886","article-title":"Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing","volume":"3","author":"Chen","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2015.06.147_bib15","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.108.176826","article-title":"Paracrine mechanisms in adult stem cell signaling and therapy","volume":"21","author":"Gnecchi","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2015.06.147_bib16","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1089\/ten.tec.2009.0208","article-title":"Properties of hepatocyte-like cell clusters from human adipose tissue-derived mesenchymal stem cells","volume":"16","author":"Okura","year":"2010","journal-title":"Tissue Eng. Part C Methods"},{"key":"10.1016\/j.bbrc.2015.06.147_bib17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1089\/ten.tec.2010.0139","article-title":"Transplantation of human adipose tissue-derived multilineage progenitor cells reduces serum cholesterol in hyperlipidemic Watanabe rabbits","volume":"17","author":"Okura","year":"2011","journal-title":"Tissue Eng. Part C Methods"},{"key":"10.1016\/j.bbrc.2015.06.147_bib18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0021-9258(18)43072-4","article-title":"A\u00a0method for the rapid determination of alkaline phosphates with five cubic millimeters of serum","volume":"164","author":"Bessey","year":"1946","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2015.06.147_bib19","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0003-2697(80)90165-7","article-title":"A\u00a0simple, rapid, and sensitive DNA assay procedure","volume":"102","author":"Labarca","year":"1980","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbrc.2015.06.147_bib20","doi-asserted-by":"crossref","first-page":"23070","DOI":"10.1074\/jbc.M611181200","article-title":"PLAP-1\/asporin, a novel negative regulator of periodontal ligament mineralization","volume":"282","author":"Yamada","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2015.06.147_bib21","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3181\/00379727-80-19661","article-title":"A\u00a0simple and sensitive histochemical method for calcium","volume":"80","author":"Dahl","year":"1952","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.bbrc.2015.06.147_bib22","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1161\/01.ATV.0000190701.92007.6d","article-title":"Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells","volume":"25","author":"Nakagami","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2015.06.147_bib23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jdermsci.2007.05.018","article-title":"Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts","volume":"48","author":"Kim","year":"2007","journal-title":"J.\u00a0Dermatol Sci."},{"key":"10.1016\/j.bbrc.2015.06.147_bib24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/0022034513511640","article-title":"Cooperative effects of FGF-2 and VEGF-A in periodontal ligament cells","volume":"93","author":"Yanagita","year":"2014","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.bbrc.2015.06.147_bib25","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00441-012-1392-x","article-title":"Effects of VEGF and FGF-2 on proliferation and differentiation of human periodontal ligament stem cells","volume":"348","author":"Lee","year":"2012","journal-title":"Cell. Tissue Res."},{"key":"10.1016\/j.bbrc.2015.06.147_bib26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1507\/endocrj.49.273","article-title":"Hepatocyte growth factor as cardiovascular hormone: role of HGF in the pathogenesis of cardiovascular disease","volume":"49","author":"Morishita","year":"2002","journal-title":"Endocr. J."},{"key":"10.1016\/j.bbrc.2015.06.147_bib27","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1634\/stemcells.2007-0388","article-title":"Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization","volume":"25","author":"Cai","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbrc.2015.06.147_bib28","first-page":"761","article-title":"The insulin-like growth factor-binding protein (IGFBP) superfamily","volume":"20","author":"Hwa","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbrc.2015.06.147_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.febslet.2004.04.091","article-title":"Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions","volume":"18","author":"Headey","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2015.06.147_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2121-11-44","article-title":"Crosstalks between integrin alpha 5 and IGF2\/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation","volume":"11","author":"Hamidouche","year":"2010","journal-title":"BMC Cell. Biol."},{"key":"10.1016\/j.bbrc.2015.06.147_bib31","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mce.2011.03.011","article-title":"A\u00a0novel interaction between insulin-like growth factor binding protein-6 and the vitamin D receptor inhibits the role of vitamin D3 in osteoblast differentiation","volume":"338","author":"Cui","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbrc.2015.06.147_bib32","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1210\/er.2001-0044","article-title":"Modulation of growth factor\/cytokine synthesis and signaling by 1alpha,25-dihydroxyvitamin D(3): implications in cell growth and differentiation","volume":"23","author":"Gurlek","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbrc.2015.06.147_bib33","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.archoralbio.2011.10.005","article-title":"1alpha,25-Dihydroxyvitamin D3 inhibits osteoblastic differentiation of mouse periodontal fibroblasts","volume":"57","author":"Chen","year":"2012","journal-title":"Arch. Oral Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15302011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15302011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T08:59:23Z","timestamp":1655888363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X15302011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0006291X15302011"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.06.147","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trophic factors from adipose tissue-derived multi-lineage progenitor cells promote cytodifferentiation of periodontal ligament cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.06.147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}