{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:19:42Z","timestamp":1761059982421},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Beijing Nova Program of Science and Technology","award":["2007B024"],"award-info":[{"award-number":["2007B024"]}]},{"DOI":"10.13039\/501100004602","name":"New Century Excellent Talents in University","doi-asserted-by":"publisher","award":["NECT-12-0773"],"award-info":[{"award-number":["NECT-12-0773"]}],"id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371203"],"award-info":[{"award-number":["31371203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.bbrc.2015.07.161","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T18:21:35Z","timestamp":1439403695000},"page":"665-669","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Keratin 8 is a novel autoantigen of rheumatoid arthritis"],"prefix":"10.1016","volume":"465","author":[{"given":"Xiaoxu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhe","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwu","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2015.07.161_bib1","first-page":"587","article-title":"Putative approaches to bypass the citrulline-specific autoimmune response in rheumatoid arthritis","volume":"16","author":"Gertel","year":"2014","journal-title":"Isr. Med. Assoc. J."},{"key":"10.1016\/j.bbrc.2015.07.161_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/003693308002500104","article-title":"Liver disease in rheumatoid arthritis","volume":"25","author":"Mills","year":"1980","journal-title":"Scott. Med. J."},{"key":"10.1016\/j.bbrc.2015.07.161_bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jbspin.2006.06.012","article-title":"Association between rheumatoid arthritis and primary biliary cirrhosis","volume":"74","author":"Caramella","year":"2007","journal-title":"Jt. Bone Spine"},{"key":"10.1016\/j.bbrc.2015.07.161_bib4","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1093\/rheumatology\/40.11.1256","article-title":"The prevalence and incidence of peripheral arthritis in patients with inflammatory bowel disease, a prospective population-based study (the IBSEN study)","volume":"40","author":"Palm","year":"2001","journal-title":"Rheumatol. Oxf."},{"key":"10.1016\/j.bbrc.2015.07.161_bib5","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/archderm.1980.01640320063016","article-title":"Multiple keratoacanthomas associated with steatocystoma multiplex and rheumatoid arthritis. A case report","volume":"116","author":"Sohn","year":"1980","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.bbrc.2015.07.161_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ceb.2014.12.008","article-title":"Keratins in health and disease","volume":"32","author":"Toivola","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbrc.2015.07.161_bib7","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1172\/JCI115921","article-title":"Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex","volume":"90","author":"Steiner","year":"1992","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2015.07.161_bib8","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/ard.2007.080267","article-title":"Serum IgG antibodies to peptidylarginine deiminase 4 in rheumatoid arthritis and associations with disease severity","volume":"67","author":"Halvorsen","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrc.2015.07.161_bib9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.autrev.2009.11.017","article-title":"Profiling of rheumatoid arthritis associated autoantibodies","volume":"9","author":"Conrad","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.bbrc.2015.07.161_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1600-0625.2009.01006.x","article-title":"Expression of keratins in cutaneous epithelial tumors and related disorders\u2013distribution and clinical significance","volume":"20","author":"Kurokawa","year":"2011","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbrc.2015.07.161_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0955-0674(97)80151-2","article-title":"Intermediate filaments and cytoplasmic networking: new connections and more functions","volume":"9","author":"Chou","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbrc.2015.07.161_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3899\/jrheum.120751","article-title":"Screening citrullinated proteins in synovial tissues of rheumatoid arthritis using 2-dimensional western blotting","volume":"40","author":"Chang","year":"2013","journal-title":"J.\u00a0Rheumatol."},{"key":"10.1016\/j.bbrc.2015.07.161_bib13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1083\/jcb.200603161","article-title":"New consensus nomenclature for mammalian keratins","volume":"174","author":"Schweizer","year":"2006","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2015.07.161_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/bmj.2.6182.97","article-title":"Anti-keratin antibodies in rheumatoid arthritis","volume":"2","author":"Young","year":"1979","journal-title":"Br. Med. J."},{"key":"10.1016\/j.bbrc.2015.07.161_bib15","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1172\/JCI116713","article-title":"The cytokeratin filament-aggregating protein filaggrin is the target of the so-called \u201cantikeratin antibodies\u201d, autoantibodies specific for rheumatoid arthritis","volume":"92","author":"Simon","year":"1993","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2015.07.161_bib16","first-page":"838","article-title":"Immunoblotting detection of autoantibodies to human epidermis filaggrin: a new diagnostic test for rheumatoid arthritis","volume":"25","author":"Vincent","year":"1998","journal-title":"J.\u00a0Rheumatol."},{"key":"10.1016\/j.bbrc.2015.07.161_bib17","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1172\/JCI117969","article-title":"The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies","volume":"95","author":"Sebbag","year":"1995","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2015.07.161_bib18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/ard.58.1.42","article-title":"Anti-perinuclear factor compared with the so called \u201cantikeratin\u201d antibodies and antibodies to human epidermis filaggrin, in the diagnosis of arthritides","volume":"58","author":"Vincent","year":"1999","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrc.2015.07.161_bib19","first-page":"847","article-title":"Diagnostic value of antibodies to filaggrin in rheumatoid arthritis","volume":"25","author":"Slack","year":"1998","journal-title":"J.\u00a0Rheumatol."},{"key":"10.1016\/j.bbrc.2015.07.161_bib20","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00296-008-0809-z","article-title":"Prevalence of rheumatic diseases and disability in China","volume":"29","author":"Xiang","year":"2009","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.bbrc.2015.07.161_bib21","first-page":"2245","article-title":"Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: a COPCORD study","volume":"30","author":"Dai","year":"2003","journal-title":"J.\u00a0Rheumatol."},{"key":"10.1016\/j.bbrc.2015.07.161_bib22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0889-857X(05)70201-5","article-title":"The epidemiology of rheumatoid arthritis","volume":"27","author":"Gabriel","year":"2001","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"10.1016\/j.bbrc.2015.07.161_bib23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2015.07.161_bib24","doi-asserted-by":"crossref","first-page":"8162","DOI":"10.1038\/srep08162","article-title":"Annexin A2 as a target endothelial cell membrane autoantigen in Behcet's disease","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2015.07.161_bib25","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.4155\/bio.12.188","article-title":"Immunological screening and characterization of highly specific monoclonal antibodies against 20\u00a0kDa hGH","volume":"4","author":"Du","year":"2012","journal-title":"Bioanalysis"},{"key":"10.1016\/j.bbrc.2015.07.161_bib26","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbrc.2014.07.126","article-title":"Identification of prohibitin as an antigen in Behcet's disease","volume":"451","author":"Xun","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.07.161_bib27","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.4155\/bio.13.195","article-title":"Generation and evaluation of antibodies against human MGF E-peptide by reverse phase protein microarray and reverse competitive ELISA","volume":"5","author":"Du","year":"2013","journal-title":"Bioanalysis"},{"key":"10.1016\/j.bbrc.2015.07.161_bib28","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1080\/00032719.2014.891125","article-title":"Determination of deoxynivalenol, zearalenone, aflatoxin B1, and ochratoxin by an enzyme-linked immunosorbent assay","volume":"47","author":"Du","year":"2014","journal-title":"Anal. Lett."},{"key":"10.1016\/j.bbrc.2015.07.161_bib29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.bbrc.2015.07.161_bib30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1745-7580-2-2","article-title":"Improved method for predicting linear B-cell epitopes","volume":"2","author":"Larsen","year":"2006","journal-title":"Immunome Res."},{"key":"10.1016\/j.bbrc.2015.07.161_bib31","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1074\/jbc.M110.171314","article-title":"Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation","volume":"286","author":"Snider","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2015.07.161_bib32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/MOG.0b013e3283525cb8","article-title":"Keratins: markers and modulators of liver disease","volume":"28","author":"Strnad","year":"2012","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.bbrc.2015.07.161_bib33","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00418-008-0435-6","article-title":"The human keratins: biology and pathology","volume":"129","author":"Moll","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2015.07.161_bib34","first-page":"1205","article-title":"Immunohistochemical study of basaloid squamous cell carcinoma, adenoid cystic and mucoepidermoid carcinoma in the upper aerodigestive tract","volume":"20","author":"Tsubochi","year":"2000","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbrc.2015.07.161_bib35","first-page":"167","article-title":"Cytokeratin profiles identify diagnostic signatures in colorectal cancer using multiplex analysis of tissue microarrays","volume":"28","author":"Knosel","year":"2006","journal-title":"Cell. Oncol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15303909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15303909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T07:56:38Z","timestamp":1537430198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X15303909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0006291X15303909"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.07.161","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Keratin 8 is a novel autoantigen of rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.07.161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}