{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:00:54Z","timestamp":1783548054402,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61070137"],"award-info":[{"award-number":["61070137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61201312"],"award-info":[{"award-number":["61201312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61170183"],"award-info":[{"award-number":["61170183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Doctoral Program of Higher Education of China","award":["20130203110017"],"award-info":[{"award-number":["20130203110017"]}]},{"name":"Central Universities of China","award":["BDY171416"],"award-info":[{"award-number":["BDY171416"]}]},{"name":"Central Universities of China","award":["JB140306"],"award-info":[{"award-number":["JB140306"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.bbrc.2015.08.033","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T13:34:20Z","timestamp":1439559260000},"page":"437-442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["A network-based approach to identify disease-associated gene modules through integrating DNA methylation and gene expression"],"prefix":"10.1016","volume":"465","author":[{"given":"Yuanyuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6696-0085","authenticated-orcid":false,"given":"Shouheng","family":"Tuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2015.08.033_bib1","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.2337\/db10-0979","article-title":"Epigenetic gene promoter methylation at birth is associated with child's later adiposity","volume":"60","author":"Godfrey","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2015.08.033_bib2","doi-asserted-by":"crossref","first-page":"e1001551","DOI":"10.1371\/journal.pmed.1001551","article-title":"Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development","volume":"10","author":"Jones","year":"2013","journal-title":"PLoS Med."},{"key":"10.1016\/j.bbrc.2015.08.033_bib3","doi-asserted-by":"crossref","first-page":"692","DOI":"10.4161\/epi.6.6.16196","article-title":"Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome","volume":"6","author":"Sandoval","year":"2011","journal-title":"Epigenetics"},{"key":"10.1016\/j.bbrc.2015.08.033_bib4","doi-asserted-by":"crossref","first-page":"829","DOI":"10.4161\/epi.28790","article-title":"Validation of DNA methylation profiling in formalin-fixed paraffin-embedded samples using the Infinium HumanMethylation450 Microarray","volume":"9","author":"Moran","year":"2014","journal-title":"Epigenetics"},{"key":"10.1016\/j.bbrc.2015.08.033_bib5","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1101\/gr.074914.107","article-title":"A\u00a0gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility","volume":"18","author":"Keller","year":"2008","journal-title":"Genome Res."},{"key":"10.1016\/j.bbrc.2015.08.033_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cell.2013.03.008","article-title":"Interplay between the cancer genome and epigenome","volume":"153","author":"Shen","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2015.08.033_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrg3868","article-title":"Methods of integrating data to uncover genotype-phenotype interactions","volume":"16","author":"Ritchie","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbrc.2015.08.033_bib8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrc3721","article-title":"Principles and methods of integrative genomic analyses in cancer","volume":"14","author":"Kristensen","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2015.08.033_bib9","doi-asserted-by":"crossref","first-page":"R10","DOI":"10.1186\/gb-2011-12-1-r10","article-title":"DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines","volume":"12","author":"Bell","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbrc.2015.08.033_bib10","doi-asserted-by":"crossref","first-page":"r137","DOI":"10.1186\/gb-2013-14-12-r137","article-title":"Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas","volume":"14","author":"Renner","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbrc.2015.08.033_bib11","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1101\/gr.132662.111","article-title":"Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression","volume":"22","author":"Selamat","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.bbrc.2015.08.033_bib12","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1039\/C3MB70270G","article-title":"A\u00a0network-based, integrative approach to identify genes with aberrant co-methylation in colorectal cancer","volume":"10","author":"Li","year":"2014","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.bbrc.2015.08.033_bib13","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/1752-0509-5-158","article-title":"Prioritizing cancer-related genes with aberrant methylation based on a weighted protein-protein interaction network","volume":"5","author":"Liu","year":"2011","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.bbrc.2015.08.033_bib14","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1186\/s12918-014-0136-9","article-title":"Integrative network analysis of TCGA data for ovarian cancer","volume":"8","author":"Zhang","year":"2014","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.bbrc.2015.08.033_bib15","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1093\/bioinformatics\/btu433","article-title":"Network-based analysis identifies epigenetic biomarkers of esophageal squamous cell carcinoma progression","volume":"30","author":"Cheng","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2015.08.033_bib16","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1002\/sim.5694","article-title":"Network-based regularization for matched case-control analysis of high-dimensional DNA methylation data","volume":"32","author":"Sun","year":"2013","journal-title":"Stat. Med."},{"key":"10.1016\/j.bbrc.2015.08.033_bib17","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1752-0509-7-134","article-title":"Integrating gene and protein expression data with genome-scale metabolic networks to infer functional pathways","volume":"7","author":"Pey","year":"2013","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.bbrc.2015.08.033_bib18","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nrg3552","article-title":"Integrative approaches for finding modular structure in biological networks","volume":"14","author":"Mitra","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbrc.2015.08.033_bib19","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1093\/bioinformatics\/btu316","article-title":"A\u00a0systems-level integrative framework for genome-wide DNA methylation and gene expression data identifies differential gene expression modules under epigenetic control","volume":"30","author":"Jiao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2015.08.033_bib20","doi-asserted-by":"crossref","first-page":"e84573","DOI":"10.1371\/journal.pone.0084573","article-title":"A\u00a0DNA methylation network interaction measure, and detection of network oncomarkers","volume":"9","author":"Bartlett","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2015.08.033_bib21","doi-asserted-by":"crossref","first-page":"D767","DOI":"10.1093\/nar\/gkn892","article-title":"Human Protein Reference Database \u2013 2009 update","volume":"37","author":"Keshava Prasad","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2015.08.033_bib22","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1039\/C5MB00141B","article-title":"Identification of functionally methylated regions based on discriminant analysis through integrating methylation and gene expression data","volume":"11","author":"Zhang","year":"2015","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.bbrc.2015.08.033_bib23","doi-asserted-by":"crossref","first-page":"09008","DOI":"10.1088\/1742-5468\/2005\/09\/P09008","article-title":"Comparing community structure identification","volume":"9","author":"Danon","year":"2005","journal-title":"J.\u00a0Stat. Mech. Theory Exp."},{"key":"10.1016\/j.bbrc.2015.08.033_bib24","first-page":"284","article-title":"Computing communities in large networks using random walks (long version)","volume":"10","author":"Pons","year":"2004","journal-title":"J.\u00a0Graph Alg. App. bf"},{"key":"10.1016\/j.bbrc.2015.08.033_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2015.08.033_bib26","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.bcp.2005.07.024","article-title":"Inhibition of Sp1 activity by a decoy PNA\u2013DNA chimera prevents urokinase receptor expression and migration of breast cancer cells","volume":"70","author":"Zannetti","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2015.08.033_bib27","doi-asserted-by":"crossref","first-page":"6161","DOI":"10.1158\/0008-5472.CAN-14-1119","article-title":"BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development","volume":"74","author":"Bai","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2015.08.033_bib28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.canlet.2014.08.042","article-title":"The cell cycle profiling-risk score based on CDK1 and 2 predicts early recurrence in node-negative, hormone receptor-positive breast cancer treated with endocrine therapy","volume":"355","author":"Kim","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2015.08.033_bib29","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/carcin\/bgl067","article-title":"Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer","volume":"27","author":"Wirtenberger","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbrc.2015.08.033_bib30","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.18632\/oncotarget.2086","article-title":"Visfatin promotes cell and tumor growth by upregulating Notch1 in breast cancer","volume":"5","author":"Park","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2015.08.033_bib31","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1002\/ijc.24108","article-title":"Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker","volume":"124","author":"Sadr-Nabavi","year":"2009","journal-title":"Int. J. Cancer"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1530423X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1530423X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T02:54:42Z","timestamp":1537412082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X1530423X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0006291X1530423X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.08.033","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A network-based approach to identify disease-associated gene modules through integrating DNA methylation and gene expression","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.08.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}