{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:38:08Z","timestamp":1761964688669,"version":"3.41.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.bbrc.2015.09.106","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T21:43:01Z","timestamp":1443217381000},"page":"121-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Identification of the determinants of 2-deoxyglucose sensitivity in cancer cells by shRNA library screening"],"prefix":"10.1016","volume":"467","author":[{"given":"Hiroki","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruna","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2015.09.106_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrc2981","article-title":"Regulation of cancer cell metabolism","volume":"11","author":"Cairns","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2015.09.106_bib2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2015.09.106_bib3","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1038\/sj.onc.1209597","article-title":"Glycolysis inhibition for anticancer treatment","volume":"25","author":"Pelicano","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2015.09.106_bib4","doi-asserted-by":"crossref","first-page":"e532","DOI":"10.1038\/cddis.2013.60","article-title":"Targeting cellular metabolism to improve cancer therapeutics","volume":"4","author":"Zhao","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2015.09.106_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/gerona\/56.suppl_1.20","article-title":"Caloric restriction mimetics: metabolic interventions","volume":"56","author":"Weindruch","year":"2001","journal-title":"J.\u00a0Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbrc.2015.09.106_bib6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2217\/fon.09.44","article-title":"Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy","volume":"5","author":"Dwarakanath","year":"2009","journal-title":"Future Oncol."},{"key":"10.1016\/j.bbrc.2015.09.106_bib7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00280-012-2045-1","article-title":"A\u00a0phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors","volume":"71","author":"Raez","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.bbrc.2015.09.106_bib8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00066-005-1320-z","article-title":"Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme","volume":"181","author":"Singh","year":"2005","journal-title":"Strahlenther Onkol."},{"key":"10.1016\/j.bbrc.2015.09.106_bib9","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.cell.2006.01.040","article-title":"A\u00a0lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen","volume":"124","author":"Moffat","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2015.09.106_bib10","doi-asserted-by":"crossref","first-page":"20380","DOI":"10.1073\/pnas.0810485105","article-title":"Highly parallel identification of essential genes in cancer cells","volume":"105","author":"Luo","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2015.09.106_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0092-8674(93)90295-2","article-title":"Beta-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in\u00a0vivo","volume":"74","author":"Pepperkok","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2015.09.106_bib12","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1083\/jcb.122.6.1155","article-title":"Beta-COP is essential for transport of protein from the endoplasmic reticulum to the Golgi in\u00a0vitro","volume":"122","author":"Peter","year":"1993","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2015.09.106_bib13","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1002\/j.1460-2075.1996.tb00528.x","article-title":"Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval","volume":"15","author":"Cosson","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2015.09.106_bib14","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1016\/j.febslet.2009.07.032","article-title":"The COPI system: molecular mechanisms and function","volume":"583","author":"Beck","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2015.09.106_bib15","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nchembio.1359","article-title":"Development of small-molecule inhibitors targeting adipose triglyceride lipase","volume":"9","author":"Mayer","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbrc.2015.09.106_bib16","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1021\/bi002426w","article-title":"Hypersensitization of tumor cells to glycolytic inhibitors","volume":"40","author":"Liu","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2015.09.106_bib17","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1158\/0008-5472.CAN-09-2782","article-title":"Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells","volume":"70","author":"Ben Sahra","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2015.09.106_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.cellbio.20.010403.105307","article-title":"Bi-directional protein transport between the ER and Golgi","volume":"20","author":"Lee","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2015.09.106_bib19","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0005-2760(77)90035-2","article-title":"Regulation of lipolysis and cyclic AMP synthesis through energy supply in isolated human fat cells","volume":"486","author":"Giudicelli","year":"1977","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2015.09.106_bib20","first-page":"E218","article-title":"Lipolytic response to glucose infusion in human subjects","volume":"252","author":"Wolfe","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2015.09.106_bib21","doi-asserted-by":"crossref","first-page":"519S","DOI":"10.1093\/ajcn\/67.3.519S","article-title":"Metabolic interactions between glucose and fatty acids in humans","volume":"67","author":"Wolfe","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbrc.2015.09.106_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.plipres.2010.10.004","article-title":"Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores","volume":"50","author":"Lass","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbrc.2015.09.106_bib23","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1242\/jcs.045849","article-title":"Coatomer-dependent protein delivery to lipid droplets","volume":"122","author":"Soni","year":"2009","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2015.09.106_bib24","doi-asserted-by":"crossref","first-page":"e292","DOI":"10.1371\/journal.pbio.0060292","article-title":"COPI complex is a regulator of lipid homeostasis","volume":"6","author":"Beller","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbrc.2015.09.106_bib25","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/cncr.11159","article-title":"Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma","volume":"97","author":"Kunkel","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.bbrc.2015.09.106_bib26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00268-003-7191-5","article-title":"Evaluation of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography for gastric cancer","volume":"28","author":"Mochiki","year":"2004","journal-title":"World J. Surg."},{"key":"10.1016\/j.bbrc.2015.09.106_bib27","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/nrc1478","article-title":"Why do cancers have high aerobic glycolysis?","volume":"4","author":"Gatenby","year":"2004","journal-title":"Nat. Rev. Cancer"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.bbrc.2015.09.106_bib28","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.4103\/0973-1482.55136","article-title":"Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: present status and future prospects","volume":"5","author":"Dwarakanath","year":"2009","journal-title":"J.\u00a0Cancer Res. Ther."},{"key":"10.1016\/j.bbrc.2015.09.106_bib29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/35043117","article-title":"Three ways to make a vesicle","volume":"1","author":"Kirchhausen","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2015.09.106_bib30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.33549\/physiolres.930000.49.213","article-title":"Glucose as a lipolytic agent: studies on isolated rat adipocytes","volume":"49","author":"Szkudelski","year":"2000","journal-title":"Physiol. Res."},{"key":"10.1016\/j.bbrc.2015.09.106_bib31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/0008-5472.CAN-03-3294","article-title":"2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in\u00a0vivo","volume":"64","author":"Maschek","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2015.09.106_bib32","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1158\/0008-5472.CAN-06-3717","article-title":"2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells","volume":"67","author":"Simons","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2015.09.106_bib33","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/ijc.23525","article-title":"Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir","volume":"123","author":"Hernlund","year":"2008","journal-title":"Int. J. Cancer"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15306239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15306239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T20:25:47Z","timestamp":1748636747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X15306239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0006291X15306239"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.09.106","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of the determinants of 2-deoxyglucose sensitivity in cancer cells by shRNA library screening","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.09.106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}