{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:47:08Z","timestamp":1790282828240,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.bbrc.2015.10.101","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T01:20:54Z","timestamp":1445822454000},"page":"463-469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Deregulation of energy metabolism promotes antifibrotic effects in human hepatic stellate cells and prevents liver fibrosis in a mouse model"],"prefix":"10.1016","volume":"469","author":[{"given":"Swathi","family":"Karthikeyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Francois","family":"Geschwind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surojit","family":"Sur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Vogelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Kinzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Mezey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanmugasundaram","family":"Ganapathy-Kanniappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2015.10.101_bib1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bpg.2011.02.009","article-title":"Liver cirrhosis","volume":"25","author":"Pinzani","year":"2011","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.bbrc.2015.10.101_bib2","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S0168-8278(12)60003-8","article-title":"Management of critically-ill cirrhotic patients","volume":"56","author":"Gines","year":"2012","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2015.10.101_bib3","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s005350070045","article-title":"Hepatic stellate cells: a target for the treatment of liver fibrosis","volume":"35","author":"Wu","year":"2000","journal-title":"J.\u00a0Gastroenterol."},{"key":"10.1016\/j.bbrc.2015.10.101_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4103\/1319-3767.96445","article-title":"Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches","volume":"18","author":"Ahmad","year":"2012","journal-title":"Saudi J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2015.10.101_bib5","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.bbadis.2012.11.002","article-title":"Extracellular matrix degradation in liver fibrosis: biochemistry and regulation","volume":"1832","author":"Iredale","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2015.10.101_bib6","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cld.2008.07.008","article-title":"Cellular sources of extracellular matrix in hepatic fibrosis","volume":"12","author":"Wells","year":"2008","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.bbrc.2015.10.101_bib7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jhep.2014.04.017","article-title":"Is the pathway of energy metabolism modified in advanced cirrhosis?","volume":"61","author":"Ganapathy-Kanniappan","year":"2014","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2015.10.101_bib8","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.jhep.2014.02.014","article-title":"A\u00a0switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease","volume":"60","author":"Nishikawa","year":"2014","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2015.10.101_bib9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2174\/138920110791591427","article-title":"3-bromopyruvate: a new targeted antiglycolytic agent and a promise for cancer therapy","volume":"11","author":"Ganapathy-Kanniappan","year":"2010","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.bbrc.2015.10.101_bib10","first-page":"13","article-title":"Anticancer efficacy of the metabolic blocker 3-bromopyruvate: specific molecular targeting","volume":"33","author":"Ganapathy-Kanniappan","year":"2013","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbrc.2015.10.101_bib11","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.1158\/1078-0432.CCR-14-1271","article-title":"Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer","volume":"20","author":"Chapiro","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2015.10.101_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0945-053X(03)00017-9","article-title":"Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cells","volume":"22","author":"Gaca","year":"2003","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbrc.2015.10.101_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0168-8278(02)00103-4","article-title":"Reversal of activation of human myofibroblast-like cells by culture on a basement membrane-like substrate","volume":"37","author":"Sohara","year":"2002","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2015.10.101_bib14","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.06.036","article-title":"Deactivation of hepatic stellate cells during liver fibrosis resolution in mice","volume":"143","author":"Troeger","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2015.10.101_bib15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.bbrc.2003.10.167","article-title":"Activation of the human alpha1(I) collagen promoter by leptin is not mediated by transforming growth factor beta responsive elements","volume":"312","author":"Tang","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.10.101_bib16","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/jcp.22824","article-title":"AMP-activated protein kinase inhibits TGF-beta-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300","volume":"227","author":"Lim","year":"2012","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.bbrc.2015.10.101_bib17","doi-asserted-by":"crossref","first-page":"6816","DOI":"10.1038\/srep06816","article-title":"Reversal of anchorage-independent multicellular spheroid into a monolayer mimics a metastatic model","volume":"4","author":"Kunjithapatham","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2015.10.101_bib18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbadis.2006.08.009","article-title":"Effects of retinoic acid on the development of liver fibrosis produced by carbon tetrachloride in mice","volume":"1772","author":"Wang","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2015.10.101_bib19","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1148\/radiol.11111569","article-title":"Human hepatocellular carcinoma in a mouse model: assessment of tumor response to percutaneous ablation by using glyceraldehyde-3-phosphate dehydrogenase antagonists","volume":"262","author":"Ganapathy-Kanniappan","year":"2012","journal-title":"Radiology"},{"key":"10.1016\/j.bbrc.2015.10.101_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0925-4773(02)00338-6","article-title":"The role of hepatocytes and oval cells in liver regeneration and repopulation","volume":"120","author":"Fausto","year":"2003","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bbrc.2015.10.101_bib21","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.drudis.2007.04.001","article-title":"Identifying and validating novel targets with in\u00a0vivo disease models: guidelines for study design","volume":"12","author":"Anders","year":"2007","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bbrc.2015.10.101_bib22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrgastro.2010.97","article-title":"Evolving challenges in hepatic fibrosis","volume":"7","author":"Friedman","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2015.10.101_bib23","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1172\/JCI66028","article-title":"Evolving therapies for liver fibrosis","volume":"123","author":"Schuppan","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2015.10.101_bib24","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jhep.2013.02.016","article-title":"Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy","volume":"59","author":"Hernandez-Gea","year":"2013","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2015.10.101_bib25","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1089\/ars.2013.5619","article-title":"Role of NADPH oxidases in liver fibrosis","volume":"20","author":"Paik","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.bbrc.2015.10.101_bib26","doi-asserted-by":"crossref","first-page":"825065","DOI":"10.1155\/2013\/825065","article-title":"Oxidative stress induces mitochondrial DNA damage and cytotoxicity through independent mechanisms in human cancer cells","volume":"2013","author":"Han","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bbrc.2015.10.101_bib27","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.arr.2012.10.004","article-title":"Oxidative stress and cancer: an overview","volume":"12","author":"Sosa","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbrc.2015.10.101_bib28","first-page":"923","article-title":"3-bromopyruvate induces endoplasmic reticulum stress, overcomes autophagy and causes apoptosis in human HCC cell lines","volume":"30","author":"Ganapathy-Kanniappan","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbrc.2015.10.101_bib29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.trsl.2011.08.008","article-title":"Systemic administration of 3-bromopyruvate in treating disseminated aggressive lymphoma","volume":"159","author":"Schaefer","year":"2012","journal-title":"Transl. Res."},{"key":"10.1016\/j.bbrc.2015.10.101_bib30","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.07.115","article-title":"Hedgehog controls hepatic stellate cell fate by regulating metabolism","volume":"143","author":"Chen","year":"2012","journal-title":"Gastroenterology"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15308019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15308019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T08:23:52Z","timestamp":1537259032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X15308019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0006291X15308019"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.10.101","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deregulation of energy metabolism promotes antifibrotic effects in human hepatic stellate cells and prevents liver fibrosis in a mouse model","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.10.101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}