{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:52:19Z","timestamp":1760820739216,"version":"3.40.5"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["7346"],"award-info":[{"award-number":["7346"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cell Sheet Tissue Engineering Center"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.bbrc.2015.10.155","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T04:42:27Z","timestamp":1447130547000},"page":"704-709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characterization of rabbit limbal epithelial side population cells using RNA sequencing and single-cell qRT-PCR"],"prefix":"10.1016","volume":"473","author":[{"given":"Sumako","family":"Kameishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terumasa","family":"Umemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruo","family":"Okano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-1024","authenticated-orcid":false,"given":"Masayuki","family":"Yamato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Pt 19","key":"10.1016\/j.bbrc.2015.10.155_bib1","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1242\/jcs.111.19.2867","article-title":"Strategies of epithelial repair: modulation of stem cell and transit amplifying cell proliferation","volume":"111","author":"Lehrer","year":"1998","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2015.10.155_bib2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/19539","article-title":"p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development","volume":"398","author":"Yang","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2015.10.155_bib3","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1073\/pnas.061032098","article-title":"p63 identifies keratinocyte stem cells","volume":"98","author":"Pellegrini","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2015.10.155_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.exer.2005.02.016","article-title":"Identification and characterization of limbal stem cells","volume":"81","author":"Schlotzer-Schrehardt","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbrc.2015.10.155_bib5","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.183.4.1797","article-title":"Isolation and functional properties of murine hematopoietic stem cells that are replicating in\u00a0vivo","volume":"183","author":"Goodell","year":"1996","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2015.10.155_bib6","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm0901-1028","article-title":"The ABC transporter Bcrp1\/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype","volume":"7","author":"Zhou","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2015.10.155_bib7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1083\/jcb.200202092","article-title":"Myogenic specification of side population cells in skeletal muscle","volume":"159","author":"Asakura","year":"2002","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2015.10.155_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/1097-0320(20000701)40:3<245::AID-CYTO10>3.0.CO;2-5","article-title":"Characterization of neurosphere cell phenotypes by flow cytometry","volume":"40","author":"Hulspas","year":"2000","journal-title":"Cytometry"},{"key":"10.1016\/j.bbrc.2015.10.155_bib9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/dbio.2002.0625","article-title":"Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population","volume":"245","author":"Welm","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbrc.2015.10.155_bib10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1634\/stemcells.2005-0064","article-title":"Limbal epithelial side-population cells have stem cell-like properties, including quiescent state","volume":"24","author":"Umemoto","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbrc.2015.10.155_bib11","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbrc.2009.08.130","article-title":"Nectin-3 expression is elevated in limbal epithelial side population cells with strongly expressed stem cell markers","volume":"389","author":"Kusanagi","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.10.155_bib12","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1634\/stemcells.2008-0824","article-title":"The adhesion molecule esam1 is a novel hematopoietic stem cell marker","volume":"27","author":"Ooi","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbrc.2015.10.155_bib13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4049\/jimmunol.1200056","article-title":"The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal","volume":"189","author":"Sudo","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2015.10.155_bib14","doi-asserted-by":"crossref","first-page":"6557","DOI":"10.1128\/MCB.00729-06","article-title":"Putative \u201cstemness\u201d gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells","volume":"26","author":"Sakaguchi","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2015.10.155_bib15","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1182\/blood.V89.12.4317","article-title":"Expression and function of murine receptor tyrosine kinases, TIE and TEK, in hematopoietic stem cells","volume":"89","author":"Yano","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2015.10.155_bib16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/bbrc.1993.2045","article-title":"Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells","volume":"195","author":"Iwama","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.10.155_bib17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.stemcr.2013.06.001","article-title":"LNGFR+THY-1+VCAM-1hi+ cells reveal functionally distinct subpopulations in mesenchymal stem cells","volume":"1","author":"Mabuchi","year":"2013","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.bbrc.2015.10.155_bib18","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1634\/stemcells.2005-0150","article-title":"Contribution of the ABC transporters Bcrp1 and Mdr1a\/1b to the side population phenotype in mammary gland and bone marrow of mice","volume":"23","author":"Jonker","year":"2005","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbrc.2015.10.155_bib19","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.celrep.2014.02.006","article-title":"A\u00a0chemical probe that labels human pluripotent stem cells","volume":"6","author":"Hirata","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2015.10.155_bib20","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nature02060","article-title":"Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation","volume":"425","author":"Molofsky","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2015.10.155_bib21","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature01587","article-title":"Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells","volume":"423","author":"Park","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2015.10.155_bib22","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/ncb2719","article-title":"Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells","volume":"15","author":"Tanaka","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2015.10.155_bib23","doi-asserted-by":"crossref","first-page":"e23833","DOI":"10.1371\/journal.pone.0023833","article-title":"Endothelial induced EMT in breast epithelial cells with stem cell properties","volume":"6","author":"Sigurdsson","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2015.10.155_bib24","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","article-title":"The epithelial-mesenchymal transition generates cells with properties of stem cells","volume":"133","author":"Mani","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2015.10.155_bib25","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.4161\/cc.10.8.15363","article-title":"p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells","volume":"10","author":"Pinho","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbrc.2015.10.155_bib26","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1056\/NEJMoa040455","article-title":"Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium","volume":"351","author":"Nishida","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2015.10.155_bib27","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1038\/mt.2014.69","article-title":"Evidence of the survival of ectopically transplanted oral mucosal epithelial stem cells after repeated wounding of cornea","volume":"22","author":"Sugiyama","year":"2014","journal-title":"Mol. Ther."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15308524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15308524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T19:02:08Z","timestamp":1653505328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X15308524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0006291X15308524"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.10.155","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of rabbit limbal epithelial side population cells using RNA sequencing and single-cell qRT-PCR","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.10.155","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}