{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:56:06Z","timestamp":1759683366189,"version":"3.37.3"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15ek0109048s0402"],"award-info":[{"award-number":["15ek0109048s0402"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18599002","26293207"],"award-info":[{"award-number":["18599002","26293207"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.bbrc.2015.11.015","type":"journal-article","created":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T07:32:56Z","timestamp":1446881576000},"page":"677-683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration"],"prefix":"10.1016","volume":"468","author":[{"given":"Ying","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-4663","authenticated-orcid":false,"given":"Hiroaki","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahisa","family":"Katsuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Mei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohide","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madoka","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genki","family":"Tohnai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Nakatsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Funakoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikazu","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2015.11.015_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/352077a0","article-title":"Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy","volume":"352","author":"La Spada","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2015.11.015_bib2","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1212\/WNL.18.7.671","article-title":"Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait","volume":"18","author":"Kennedy","year":"1968","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2015.11.015_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/ana.410440216","article-title":"Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy","volume":"44","author":"Li","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbrc.2015.11.015_bib4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/brain\/awh381","article-title":"Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients","volume":"128","author":"Adachi","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.bbrc.2015.11.015_bib5","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nm878","article-title":"Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy","volume":"9","author":"Katsuno","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2015.11.015_bib6","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nm1298","article-title":"17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration","volume":"11","author":"Waza","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2015.11.015_bib7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S1474-4422(10)70182-4","article-title":"Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"9","author":"Katsuno","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbrc.2015.11.015_bib8","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/0006-291X(84)91253-1","article-title":"Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats","volume":"122","author":"Nakamura","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.11.015_bib9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jcp.1041190207","article-title":"Partial characterization of a hepatocyte growth factor from rat platelets","volume":"119","author":"Russell","year":"1984","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.bbrc.2015.11.015_bib10","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/342440a0","article-title":"Molecular cloning and expression of human hepatocyte growth factor","volume":"342","author":"Nakamura","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2015.11.015_bib11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(95)90279-1","article-title":"Hepatocyte growth factor: a multifunctional cytokine","volume":"345","author":"Boros","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2015.11.015_bib12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.276.5309.60","article-title":"Liver regeneration","volume":"276","author":"Michalopoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2015.11.015_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/6310","article-title":"Hepatocyte growth factor, a versatile signal for developing neurons","volume":"2","author":"Maina","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrc.2015.11.015_bib14","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0896-6273(00)80247-0","article-title":"Hepatocyte growth factor\/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons","volume":"17","author":"Ebens","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2015.11.015_bib15","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1523\/JNEUROSCI.22-15-06537.2002","article-title":"Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS","volume":"22","author":"Sun","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2015.11.015_bib16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neures.2012.03.001","article-title":"Overexpression of HGF attenuates the degeneration of Purkinje cells and Bergmann glia in a knockin mouse model of spinocerebellar ataxia type 7","volume":"73","author":"Noma","year":"2012","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbrc.2015.11.015_bib17","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0896-6273(02)00834-6","article-title":"Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy","volume":"35","author":"Katsuno","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2015.11.015_bib18","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1158\/1078-0432.CCR-08-1306","article-title":"Novel therapeutic inhibitors of the c-Met signaling pathway in cancer","volume":"15","author":"Eder","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2015.11.015_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.semcancer.2008.11.010","article-title":"Is Akt the \u201cWarburg kinase\u201d?-Akt-energy metabolism interactions and oncogenesis","volume":"19","author":"Robey","year":"2009","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbrc.2015.11.015_bib20","first-page":"123","article-title":"Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators","volume":"120","author":"Jiang","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2015.11.015_bib21","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbrc.2005.11.147","article-title":"Ras regulates neuronal polarity via the PI3-kinase\/Akt\/GSK-3beta\/CRMP-2 pathway","volume":"340","author":"Yoshimura","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2015.11.015_bib22","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.neuron.2009.07.019","article-title":"Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy","volume":"63","author":"Palazzolo","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2015.11.015_bib23","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2174\/156652311798192833","article-title":"Experimental and clinical application of plasmid DNA in the field of central nervous diseases","volume":"11","author":"Shimamura","year":"2011","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.bbrc.2015.11.015_bib24","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/(SICI)1097-4547(19960301)43:5<554::AID-JNR5>3.0.CO;2-H","article-title":"Neurotrophic effect of hepatocyte growth factor on central nervous system neurons in\u00a0vitro","volume":"43","author":"Hamanoue","year":"1996","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.bbrc.2015.11.015_bib25","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1242\/dev.01209","article-title":"HGF regulates the development of cortical pyramidal dendrites","volume":"131","author":"Gutierrez","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2015.11.015_bib26","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1093\/brain\/awp258","article-title":"Clinical features of spinal and bulbar muscular atrophy","volume":"132","author":"Rhodes","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.bbrc.2015.11.015_bib27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.pneurobio.2012.05.007","article-title":"Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA)","volume":"99","author":"Katsuno","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbrc.2015.11.015_bib28","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/nm.2791","article-title":"Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2","volume":"18","author":"Miyazaki","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2015.11.015_bib29","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1093\/hmg\/ddu066","article-title":"Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy","volume":"23","author":"Tohnai","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2015.11.015_bib30","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1126\/science.290.5492.767","article-title":"Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease","volume":"290","author":"Kordower","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2015.11.015_bib31","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/hmg\/ddm109","article-title":"Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity","volume":"16","author":"Palazzolo","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2015.11.015_bib32","doi-asserted-by":"crossref","first-page":"C174","DOI":"10.1152\/ajpcell.2000.278.1.C174","article-title":"Hepatocyte growth factor affects satellite cell activation and differentiation in regenerating skeletal muscle","volume":"278","author":"Miller","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15308858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15308858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T09:02:22Z","timestamp":1655888542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X15308858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0006291X15308858"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.11.015","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}