{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:43:20Z","timestamp":1790711000238,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.bbrc.2015.11.134","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T16:57:30Z","timestamp":1450112250000},"page":"449-455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer"],"prefix":"10.1016","volume":"469","author":[{"given":"Ranganatha R.","family":"Somasagara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaushlendra","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian M.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reagan","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavanya","family":"Bachaboina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Scalici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney P.","family":"Rocconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komaraiah","family":"Palle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2015.11.134_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics, 2013, CA","volume":"63","author":"Siegel","year":"2013","journal-title":"Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2015.11.134_bib2","unstructured":"SEER Cancer Statistics Review, 1975-2012, n.d."},{"key":"10.1016\/j.bbrc.2015.11.134_bib3","unstructured":"R. Haynes, B. Kunz, The Molecular Biology of the Yeast Saccharomyces cerevisiae: Life Cycle and Inheritance, Cold Spring Harbor Laboratory, n.d."},{"key":"10.1016\/j.bbrc.2015.11.134_bib4","doi-asserted-by":"crossref","first-page":"8865","DOI":"10.1073\/pnas.88.20.8865","article-title":"Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6","volume":"88","author":"Koken","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2015.11.134_bib5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1126\/science.287.5452.501","article-title":"Rad6-dependent ubiquitination of histone H2B in yeast","volume":"287","author":"Robzyk","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2015.11.134_bib6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1101\/gad.1149604","article-title":"Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B","volume":"18","author":"Kao","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2015.11.134_bib7","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1038\/sj.onc.1207449","article-title":"RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response","volume":"23","author":"Lyakhovich","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2015.11.134_bib8","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1101\/gad.8.7.811","article-title":"Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites","volume":"8","author":"Bailly","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2015.11.134_bib9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nature00991","article-title":"RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO","volume":"419","author":"Hoege","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2015.11.134_bib10","first-page":"2115","article-title":"Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation","volume":"62","author":"Shekhar","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2015.11.134_bib11","first-page":"439205","article-title":"Melanoma development and progression are associated with rad6 upregulation and \u03b2 -catenin relocation to the cell membrane","volume":"2014","author":"Rosner","year":"2014","journal-title":"J.\u00a0Skin. Cancer"},{"key":"10.1016\/j.bbrc.2015.11.134_bib12","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1158\/0008-5472.CAN-07-2111","article-title":"Rad6B is a positive regulator of beta-catenin stabilization","volume":"68","author":"Shekhar","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2015.11.134_bib13","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1593\/neo.11138","article-title":"Molecular requirements for transformation of fallopian tube epithelial cells into serous carcinoma","volume":"13","author":"Jazaeri","year":"2011","journal-title":"Neoplasia N. Y. N."},{"key":"10.1016\/j.bbrc.2015.11.134_bib14","doi-asserted-by":"crossref","first-page":"e107142","DOI":"10.1371\/journal.pone.0107142","article-title":"ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling","volume":"9","author":"Meng","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2015.11.134_bib15","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nsmb1295","article-title":"E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages","volume":"14","author":"Christensen","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbrc.2015.11.134_bib16","doi-asserted-by":"crossref","first-page":"31513","DOI":"10.1074\/jbc.M114.606483","article-title":"Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors","volume":"289","author":"Tripathi","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"issue":"30","key":"10.1016\/j.bbrc.2015.11.134_bib17","doi-asserted-by":"crossref","first-page":"28816","DOI":"10.18632\/oncotarget.5006","article-title":"FANCJ protein is important for the stability of FANCD2\/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation","volume":"6","author":"Clark","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2015.11.134_bib18","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.18632\/oncotarget.2068","article-title":"Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4\/6-mediated survival signals","volume":"5","author":"Kumar","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2015.11.134_bib19","first-page":"105","article-title":"Hedgehog Pathway and GLI1 Isoforms in Human Cancer","volume":"13","author":"Carpenter","year":"2012","journal-title":"Discov. Med."},{"key":"10.1016\/j.bbrc.2015.11.134_bib20","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/j.bbagen.2012.08.010","article-title":"On the role of Wnt\/\u03b2-catenin signaling in stem cells","volume":"1830","author":"K\u00fchl","year":"2013","journal-title":"Biochim. Biophys. Acta BBA Gen. Subj."},{"key":"10.1016\/j.bbrc.2015.11.134_bib21","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1101\/gad.1732108","article-title":"Histone H2B ubiquitination: the cancer connection","volume":"22","author":"Espinosa","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2015.11.134_bib22","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1128\/MCB.02076-07","article-title":"DOT1L\/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells","volume":"28","author":"Steger","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2015.11.134_bib23","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1101\/gad.177220.111","article-title":"Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123","volume":"25","author":"Schulze","year":"2011","journal-title":"Genes Dev."},{"issue":"Suppl.\u00a06","key":"10.1016\/j.bbrc.2015.11.134_bib24","doi-asserted-by":"crossref","first-page":"vi24","DOI":"10.1093\/annonc\/mdt333","article-title":"Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Ledermann","year":"2013","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol. ESMO"},{"key":"10.1016\/j.bbrc.2015.11.134_bib25","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1158\/0008-5472.CAN-05-3153","article-title":"Cancer stem cells: an old idea\u2013a paradigm shift","volume":"66","author":"Wicha","year":"2006","journal-title":"Cancer Res."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.bbrc.2015.11.134_bib26","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1053\/j.seminoncol.2015.01.001","article-title":"Cancer Stem Cells: The Promise and the Potential","volume":"42","author":"Ajani","year":"2015","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.bbrc.2015.11.134_bib27","doi-asserted-by":"crossref","first-page":"e13313","DOI":"10.1371\/journal.pone.0013313","article-title":"Convergence of Rad6\/Rad18 and fanconi anemia tumor suppressor pathways upon DNA damage","volume":"5","author":"Park","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbrc.2015.11.134_bib28","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.4161\/cc.10.10.15617","article-title":"Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA topoisomerase 1 inhibition","volume":"10","author":"Palle","year":"2011","journal-title":"Cell Cycle georget. Tex"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15310032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X15310032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T17:08:02Z","timestamp":1599930482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X15310032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0006291X15310032"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.11.134","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2015.11.134","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}