{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:07:30Z","timestamp":1789409250301,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"am","delay-in-days":371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"NIH\/NIAMS Ruth L. Kirschstein National Research Service Award","doi-asserted-by":"publisher","award":["2 T32 AR007611-11A1"],"award-info":[{"award-number":["2 T32 AR007611-11A1"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense Award","doi-asserted-by":"publisher","award":["PR110276"],"award-info":[{"award-number":["PR110276"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense Award","doi-asserted-by":"publisher","award":["K08HL093216"],"award-info":[{"award-number":["K08HL093216"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense Award","doi-asserted-by":"publisher","award":["P30HL101292"],"award-info":[{"award-number":["P30HL101292"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense Award","doi-asserted-by":"publisher","award":["DOD W81XWH-12-1-0471"],"award-info":[{"award-number":["DOD W81XWH-12-1-0471"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense Award","doi-asserted-by":"publisher","award":["GM076561"],"award-info":[{"award-number":["GM076561"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense Award","doi-asserted-by":"publisher","award":["HL094643"],"award-info":[{"award-number":["HL094643"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.bbrc.2016.01.097","type":"journal-article","created":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T05:32:18Z","timestamp":1453527138000},"page":"606-612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and \u03b2-catenin signaling"],"prefix":"10.1016","volume":"470","author":[{"given":"Lauren","family":"Reinke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna P.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette S.","family":"Flozak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-7617","authenticated-orcid":false,"given":"Cara J.","family":"Gottardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.01.097_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2016.01.097_bib2","doi-asserted-by":"crossref","first-page":"658913","DOI":"10.1155\/2014\/658913","article-title":"New insight into adiponectin role in obesity and obesity-related diseases","volume":"2014","author":"Nigro","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bbrc.2016.01.097_bib3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/MOL.0b013e32814a645f","article-title":"Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease","volume":"18","author":"Lara-Castro","year":"2007","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bbrc.2016.01.097_bib4","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/nm1137","article-title":"Adiponectin-mediated modulation of hypertrophic signals in the heart","volume":"10","author":"Shibata","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2016.01.097_bib5","doi-asserted-by":"crossref","first-page":"H984","DOI":"10.1152\/ajpheart.00428.2011","article-title":"Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling","volume":"301","author":"Essick","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2016.01.097_bib6","first-page":"1431","article-title":"Cardiovascular actions of adiponectin: pathophysiologic implications","volume":"27","author":"Maia-Fernandes","year":"2008","journal-title":"Rev. Port. Cardiol."},{"key":"10.1016\/j.bbrc.2016.01.097_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1517\/14728220903530712","article-title":"Adiponectin in health and diseases: from metabolic syndrome to tissue regeneration","volume":"14","author":"Chiarugi","year":"2010","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbrc.2016.01.097_bib8","doi-asserted-by":"crossref","first-page":"R229","DOI":"10.1186\/ar4070","article-title":"The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy","volume":"14","author":"Fang","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbrc.2016.01.097_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF03401534","article-title":"Adiponectin: regulation of its production and its role in human diseases","volume":"11","author":"Shehzad","year":"2012","journal-title":"Horm. (Athens)"},{"key":"10.1016\/j.bbrc.2016.01.097_bib10","doi-asserted-by":"crossref","first-page":"26746","DOI":"10.1074\/jbc.270.45.26746","article-title":"A\u00a0novel serum protein similar to C1q, produced exclusively in adipocytes","volume":"270","author":"Scherer","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.01.097_bib11","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nature01705","article-title":"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects","volume":"423","author":"Yamauchi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2016.01.097_bib12","doi-asserted-by":"crossref","first-page":"10308","DOI":"10.1073\/pnas.0403382101","article-title":"T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30\/adiponectin","volume":"101","author":"Hug","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2016.01.097_bib13","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2016.01.097_bib14","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1371\/journal.pmed.0050062","article-title":"Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs?","volume":"5","author":"Selman","year":"2008","journal-title":"PLoS Med."},{"key":"10.1016\/j.bbrc.2016.01.097_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1164\/rccm.201401-0079OC","article-title":"Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis","volume":"190","author":"Lam","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbrc.2016.01.097_bib16","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1165\/rcmb.2010-0113OC","article-title":"Nuclear beta-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation","volume":"45","author":"Lam","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbrc.2016.01.097_bib17","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1002\/art.30312","article-title":"Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?","volume":"63","author":"Wei","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2016.01.097_bib18","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1002\/art.34424","article-title":"Wnt\/beta-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells","volume":"64","author":"Wei","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2016.01.097_bib19","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cell.2012.03.047","article-title":"Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes","volume":"149","author":"Naito","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2016.01.097_bib20","doi-asserted-by":"crossref","first-page":"e13778","DOI":"10.1371\/journal.pone.0013778","article-title":"PPARgamma downregulation by TGFss in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis","volume":"5","author":"Wei","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2016.01.097_bib21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1083\/jcb.200811108","article-title":"Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion","volume":"186","author":"Maher","year":"2009","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2016.01.097_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nm.2277","article-title":"Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin","volume":"17","author":"Holland","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2016.01.097_bib23","doi-asserted-by":"crossref","first-page":"R184","DOI":"10.1186\/ar3512","article-title":"Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways","volume":"13","author":"Koskinen","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbrc.2016.01.097_bib24","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1038\/emm.2013.141","article-title":"The role of adiponectin in the production of IL-6, IL-8, VEGF and MMPs in human endothelial cells and osteoblasts: implications for arthritic joints","volume":"46","author":"Lee","year":"2014","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2016.01.097_bib25","doi-asserted-by":"crossref","first-page":"e2142","DOI":"10.1371\/journal.pone.0002142","article-title":"Functional Wnt signaling is increased in idiopathic pulmonary fibrosis","volume":"3","author":"Konigshoff","year":"2008","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bbrc.2016.01.097_bib26","first-page":"772","article-title":"WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis","volume":"119","author":"Konigshoff","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2016.01.097_bib27","doi-asserted-by":"crossref","first-page":"14309","DOI":"10.1073\/pnas.1001520107","article-title":"Inhibition of Wnt\/beta-catenin\/CREB binding protein (CBP) signaling reverses pulmonary fibrosis","volume":"107","author":"Henderson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2016.01.097_bib28","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1074\/jbc.M111.322123","article-title":"Axin pathway activity regulates in\u00a0vivo pY654-beta-catenin accumulation and pulmonary fibrosis","volume":"287","author":"Ulsamer","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.01.097_bib29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2016.01.097_bib30","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1126\/science.1136370","article-title":"LRP6 mutation in a family with early coronary disease and metabolic risk factors","volume":"315","author":"Mani","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2016.01.097_bib31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cmet.2013.01.009","article-title":"LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans","volume":"17","author":"Singh","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2016.01.097_bib32","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nature04185","article-title":"A\u00a0dual-kinase mechanism for Wnt co-receptor phosphorylation and activation","volume":"438","author":"Zeng","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2016.01.097_bib33","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nature04170","article-title":"Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction","volume":"438","author":"Davidson","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2016.01.097_bib34","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1128\/MCB.23.16.5825-5835.2003","article-title":"A\u00a0novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor","volume":"23","author":"Liu","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2016.01.097_bib35","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1073\/pnas.1019443108","article-title":"Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation","volume":"108","author":"Keramati","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2016.01.097_bib36","doi-asserted-by":"crossref","first-page":"11682","DOI":"10.1021\/bi801451f","article-title":"The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1\/2 through a Src\/Ras-dependent pathway and stimulate cell growth","volume":"47","author":"Lee","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2016.01.097_bib37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1183\/09031936.00114010","article-title":"Pulmonary function measures predict mortality differently in IPF versus combined pulmonary fibrosis and emphysema","volume":"38","author":"Schmidt","year":"2011","journal-title":"Eur. Respir. J."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16300973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16300973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T12:25:11Z","timestamp":1618057511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X16300973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0006291X16300973"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.01.097","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and \u03b2-catenin signaling","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.01.097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}