{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:04:32Z","timestamp":1757700272796},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.bbrc.2016.01.178","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T18:17:11Z","timestamp":1454350631000},"page":"471-476","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["The systemic effects of sclerostin overexpression using \u03a6C31 integrase in mice"],"prefix":"10.1016","volume":"472","author":[{"given":"Dongdong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Mi","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myengmo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HeeJin","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChuHyun","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Kil","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.01.178_bib1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1086\/318811","article-title":"Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein","volume":"68","author":"Brunkow","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2016.01.178_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/jmg.39.2.91","article-title":"Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease","volume":"39","author":"Balemans","year":"2002","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.bbrc.2016.01.178_bib3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jcph.239","article-title":"Multiple doses of sclerostin antibody romosozumab in healthy men and postmenopausal women with low bone mass: a randomized, double-blind, placebo-controlled study","volume":"54","author":"Padhi","year":"2014","journal-title":"J.\u00a0Clin. Pharmacol."},{"key":"10.1016\/j.bbrc.2016.01.178_bib4","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1096\/fj.05-4221fje","article-title":"Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation","volume":"19","author":"Poole","year":"2005","journal-title":"FASEB. J."},{"key":"10.1016\/j.bbrc.2016.01.178_bib5","doi-asserted-by":"crossref","first-page":"26770","DOI":"10.1074\/jbc.M504308200","article-title":"SOST is a ligand for LRP5\/LRP6 and a Wnt signaling inhibitor","volume":"280","author":"Semenov","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.01.178_bib6","doi-asserted-by":"crossref","first-page":"19489","DOI":"10.1074\/jbc.M110.190330","article-title":"Bone overgrowth-associated mutations in the LRP4 gene impair Sclerostin facilitator function","volume":"286","author":"Leupin","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.01.178_bib7","doi-asserted-by":"crossref","first-page":"E5187","DOI":"10.1073\/pnas.1413828111","article-title":"Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels","volume":"111","author":"Chang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2016.01.178_bib8","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1073\/pnas.1419714112","article-title":"Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption","volume":"112","author":"Xiong","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2016.01.178_bib9","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1359\/jbmr.080216","article-title":"Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength","volume":"23","author":"Li","year":"2008","journal-title":"J.\u00a0Bone. Miner. Res."},{"key":"10.1016\/j.bbrc.2016.01.178_bib10","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/jbmr.1608","article-title":"Absence of sclerostin adversely affects B-cell survival","volume":"27","author":"Cain","year":"2012","journal-title":"J.\u00a0Bone. Miner. Res."},{"key":"10.1016\/j.bbrc.2016.01.178_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11914-011-0050-7","article-title":"Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading","volume":"9","author":"Price","year":"2011","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bbrc.2016.01.178_bib12","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1210\/jc.2010-0720","article-title":"Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women","volume":"95","author":"Drake","year":"2010","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2016.01.178_bib13","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/jbmr.1773","article-title":"Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels","volume":"28","author":"Jastrzebski","year":"2013","journal-title":"J.\u00a0Bone. Miner. Res."},{"key":"10.1016\/j.bbrc.2016.01.178_bib14","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1210\/jc.2011-3419","article-title":"Serum sclerostin and risk of hip fracture in older Caucasian women","volume":"97","author":"Arasu","year":"2012","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2016.01.178_bib15","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1002\/jbmr.1718","article-title":"High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: the Center of Excellence for Osteoporosis Research Study","volume":"27","author":"Ardawi","year":"2012","journal-title":"J.\u00a0Bone. Miner. Res."},{"key":"10.1016\/j.bbrc.2016.01.178_bib16","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00198-012-1978-x","article-title":"Association of serum sclerostin with bone mineral density, bone turnover, steroid and parathyroid hormones, and fracture risk in postmenopausal women: the OFELY study","volume":"24","author":"Garnero","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bbrc.2016.01.178_bib17","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/jbmr.1823","article-title":"Lower fracture risk in older men with higher sclerostin concentration: a prospective analysis from the MINOS study","volume":"28","author":"Szulc","year":"2013","journal-title":"J.\u00a0Bone. Miner. Res."},{"key":"10.1016\/j.bbrc.2016.01.178_bib18","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1210\/jc.2011-2152","article-title":"Sclerostin and its association with physical activity, age, gender, body composition, and bone mineral content in healthy adults","volume":"97","author":"Amrein","year":"2012","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2016.01.178_bib19","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1128\/MCB.21.12.3926-3934.2001","article-title":"Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase","volume":"21","author":"Thyagarajan","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2016.01.178_bib20","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nbt753","article-title":"Site-specific genomic integration produces therapeutic factor IX levels in mice","volume":"20","author":"Olivares","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbrc.2016.01.178_bib21","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1073\/pnas.95.10.5505","article-title":"In\u00a0vitro site-specific integration of bacteriophage DNA catalyzed by a recombinase of the resolvase\/invertase family","volume":"95","author":"Thorpe","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2016.01.178_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jmb.2005.11.098","article-title":"Integration specificity of phage phiC31 integration specificity of phage phiC31 integrase in the human genome","volume":"357","author":"Chalberg","year":"2006","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.bbrc.2016.01.178_bib23","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1507\/endocrj.K08E-040","article-title":"Experimental parathyroid hormone gene therapy using \u00d8C31 integrase","volume":"55","author":"Lee","year":"2008","journal-title":"Endocr. J."},{"key":"10.1016\/j.bbrc.2016.01.178_bib24","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1089\/10430349950017734","article-title":"High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA","volume":"10","author":"Zhang","year":"1999","journal-title":"Hum. Gene. Ther."},{"key":"10.1016\/j.bbrc.2016.01.178_bib25","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1056\/NEJMoa1305224","article-title":"Romosozumab in postmenopausal women with low bone mineral density","volume":"370","author":"McClung","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.bbrc.2016.01.178_bib26","first-page":"S50","article-title":"Wnt1 regulates bone homeostasis by regulating the function of osteoblasts","volume":"30","author":"Joeng","year":"2015","journal-title":"J.\u00a0Bone. Miner. Res."},{"key":"10.1016\/j.bbrc.2016.01.178_bib27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-60761-369-5_13","article-title":"hESC engineering by integrase-mediated chromosomal targeting","volume":"584","author":"Liu","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbrc.2016.01.178_bib28","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1038\/sj.mt.6300314","article-title":"Hydrodynamic gene delivery: its principles and applications","volume":"15","author":"Suda","year":"2007","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbrc.2016.01.178_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2016.01.178_bib30","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.4049\/jimmunol.167.5.2625","article-title":"Connection between B lymphocyte and osteoclast differentiation pathways","volume":"167","author":"Manabe","year":"2001","journal-title":"J.\u00a0Immunol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16301784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16301784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T05:17:09Z","timestamp":1567574229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X16301784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0006291X16301784"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.01.178","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The systemic effects of sclerostin overexpression using \u03a6C31 integrase in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.01.178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}