{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T01:21:12Z","timestamp":1767144072841,"version":"build-2238731810"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Science & Engineering Research Board, Department of Science & Technology, Govt of India","award":["SB\/SO\/HS-059\/2013"],"award-info":[{"award-number":["SB\/SO\/HS-059\/2013"]}]},{"name":"Council of Scientific and Industrial Research, Government of India"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.bbrc.2016.04.094","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T20:08:27Z","timestamp":1462046907000},"page":"321-327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["FoxO3a-mediated autophagy is down-regulated in the laforin deficient mice, an animal model for Lafora progressive myoclonus epilepsy"],"prefix":"10.1016","volume":"474","author":[{"given":"Navodita","family":"Jain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subramaniam","family":"Ganesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.04.094_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10038-005-0321-1","article-title":"Recent advances in the molecular basis of Lafora's progressive myoclonus epilepsy","volume":"51","author":"Ganesh","year":"2006","journal-title":"J.\u00a0Hum. Genet."},{"key":"10.1016\/j.bbrc.2016.04.094_bib2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/humu.20954","article-title":"Lafora progressive myoclonus epilepsy: a meta-analysis of reported mutations in the first decade following the discovery of the EPM2A and NHLRC1 genes","volume":"30","author":"Singh","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bbrc.2016.04.094_bib3","series-title":"Jasper's Basic Mechanisms of the Epilepsies, National Center for Biotechnology Information (US)","article-title":"Progressive myoclonus epilepsy of Lafora","author":"Serratosa","year":"2012"},{"key":"10.1016\/j.bbrc.2016.04.094_bib4","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/hmg\/11.11.1251","article-title":"Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice","volume":"11","author":"Ganesh","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2016.04.094_bib5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s12035-013-8546-z","article-title":"Laforin-malin complex degrades polyglucosan bodies in concert with glycogen debranching enzyme and brain isoform glycogen phosphorylase","volume":"49","author":"Liu","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2016.04.094_bib6","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/hmg\/ddn398","article-title":"The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system","volume":"18","author":"Garyali","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2016.04.094_bib7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mam.2015.08.007","article-title":"Brain glycogen in health and disease","volume":"46","author":"Duran","year":"2015","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.bbrc.2016.04.094_bib8","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.4161\/rna.22708","article-title":"Lafora disease E3 ubiquitin ligase malin is recruited to the processing bodies and regulates the microRNA-mediated gene silencing process via the decapping enzyme Dcp1a","volume":"9","author":"Singh","year":"2012","journal-title":"RNA Biol."},{"key":"10.1016\/j.bbrc.2016.04.094_bib9","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/hmg\/ddq190","article-title":"Laforin, the most common protein mutated in Lafora disease, regulates autophagy","volume":"19","author":"Aguado","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2016.04.094_bib10","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1093\/hmg\/ddr590","article-title":"Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy","volume":"21","author":"Criado","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2016.04.094_bib11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/hmg\/ddr452","article-title":"Dysfunctions in endosomal-lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease","volume":"21","author":"Puri","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2016.04.094_bib12","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1091\/mbc.e13-05-0261","article-title":"Activation of serum\/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease","volume":"24","author":"Singh","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2016.04.094_bib13","doi-asserted-by":"crossref","first-page":"20606","DOI":"10.1074\/jbc.M114.580167","article-title":"Protein degradation and quality control in cells from laforin and malin knockout mice","volume":"289","author":"Garyali","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.04.094_bib14","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1128\/MCB.21.3.952-965.2001","article-title":"Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)","volume":"21","author":"Brunet","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2016.04.094_bib15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrm3507","article-title":"FOXOs: signalling integrators for homeostasis maintenance","volume":"14","author":"Eijkelenboom","year":"2013","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2016.04.094_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrm3716","article-title":"The return of the nucleus: transcriptional and epigenetic control of autophagy","volume":"15","author":"Fullgrabe","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2016.04.094_bib17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/acel.12427","article-title":"Long live FOXO: unraveling the role of FOXO proteins in aging and longevity","volume":"15","author":"Martins","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbrc.2016.04.094_bib18","doi-asserted-by":"crossref","first-page":"13987","DOI":"10.1073\/pnas.0801030105","article-title":"FOXO3A genotype is strongly associated with human longevity","volume":"105","author":"Willcox","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.bbrc.2016.04.094_bib19","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/ana.22156","article-title":"Glycogen hyperphosphorylation underlies lafora body formation","volume":"68","author":"Turnbull","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbrc.2016.04.094_bib20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbrc.2015.06.018","article-title":"Lafora disease proteins laforin and malin negatively regulate the HIPK2-p53 cell death pathway","volume":"464","author":"Upadhyay","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2016.04.094_bib21","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1242\/jcs.082800","article-title":"Malin and laforin are essential components of a protein complex that protects cells from thermal stress","volume":"124","author":"Sengupta","year":"2011","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2016.04.094_bib22","first-page":"532","article-title":"A\u00a0reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples","volume":"15","author":"Chomczynski","year":"1993","journal-title":"BioTechniques"},{"key":"10.1016\/j.bbrc.2016.04.094_bib23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/emmm.201201443","article-title":"Activation of serum\/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy","volume":"5","author":"Andres-Mateos","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbrc.2016.04.094_bib24","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.bbamcr.2011.01.007","article-title":"Regulation of FOXO protein stability via ubiquitination and proteasome degradation","volume":"1813","author":"Huang","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2016.04.094_bib25","doi-asserted-by":"crossref","first-page":"e42166","DOI":"10.1371\/journal.pone.0042166","article-title":"FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop","volume":"7","author":"Lutzner","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2016.04.094_bib26","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.1094637","article-title":"Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase","volume":"303","author":"Brunet","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2016.04.094_bib27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/ncb0208-125","article-title":"ERK and MDM2 prey on FOXO3a","volume":"10","author":"Yang","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2016.04.094_bib28","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1128\/MCB.06353-11","article-title":"The laforin-malin complex negatively regulates glycogen synthesis by modulating cellular glucose uptake via glucose transporters","volume":"32","author":"Singh","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2016.04.094_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tibs.2014.02.003","article-title":"FOXO transcription factors: key regulators of cellular quality control","volume":"39","author":"Webb","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbrc.2016.04.094_bib30","doi-asserted-by":"crossref","first-page":"32307","DOI":"10.1074\/jbc.C112.403048","article-title":"Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein","volume":"287","author":"Liu","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.04.094_bib31","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1093\/hmg\/ddt530","article-title":"FOXO3 determines the accumulation of alpha-synuclein and controls the fate of dopaminergic neurons in the substantia nigra","volume":"23","author":"Pino","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2016.04.094_bib32","doi-asserted-by":"crossref","first-page":"9138","DOI":"10.1128\/MCB.20.24.9138-9148.2000","article-title":"Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1)","volume":"20","author":"Dijkers","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2016.04.094_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s12640-011-9277-4","article-title":"Role of cell cycle re-entry in neurons: a common apoptotic mechanism of neuronal cell death","volume":"22","author":"Folch","year":"2012","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.bbrc.2016.04.094_bib34","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0197-4580(98)00071-2","article-title":"Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease","volume":"19","author":"Vincent","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbrc.2016.04.094_bib35","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.tcb.2015.02.002","article-title":"How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy","volume":"25","author":"Feng","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbrc.2016.04.094_bib36","doi-asserted-by":"crossref","first-page":"22657","DOI":"10.1074\/jbc.M109.009688","article-title":"Hyperphosphorylation and aggregation of Tau in Laforin-deficient Mice, an animal model for Lafora disease","volume":"284","author":"Puri","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.04.094_bib37","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1161\/CIRCRESAHA.110.227371","article-title":"Deacetylation of FoxO by Sirt1 Plays an essential role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes","volume":"107","author":"Hariharan","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2016.04.094_bib38","doi-asserted-by":"crossref","first-page":"28319","DOI":"10.1074\/jbc.M109.024406","article-title":"FoxO transcription factors promote autophagy in cardiomyocytes","volume":"284","author":"Sengupta","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.04.094_bib39","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.bbamcr.2011.03.013","article-title":"Interplay between FOXO, TOR, and Akt","volume":"1813","author":"Hay","year":"2011","journal-title":"Biochim. Biophys. Acta"}],"updated-by":[{"DOI":"10.1016\/j.bbrc.2018.07.052","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000}}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1630599X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1630599X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:12:53Z","timestamp":1757761973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X1630599X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0006291X1630599X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.04.094","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FoxO3a-mediated autophagy is down-regulated in the laforin deficient mice, an animal model for Lafora progressive myoclonus epilepsy","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.04.094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}