{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:23:40Z","timestamp":1790688220344,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Science and Technology Development Program of Xinxiang Central Hospital","award":["KJ-2014006"],"award-info":[{"award-number":["KJ-2014006"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.bbrc.2016.05.098","type":"journal-article","created":{"date-parts":[[2016,5,22]],"date-time":"2016-05-22T03:39:44Z","timestamp":1463888384000},"page":"245-250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Down-regulation of SIRT3 promotes ovarian carcinoma metastasis"],"prefix":"10.1016","volume":"475","author":[{"given":"Xue-cai","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-min","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-xia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.05.098_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3322\/caac.21208","article-title":"Cancer statistics, 2014","volume":"64","author":"Siegel","year":"2014","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2016.05.098_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/canjclin.50.1.7","article-title":"Cancer statistics, 2000","volume":"50","author":"Greenlee","year":"2000","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2016.05.098_bib3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrc1611","article-title":"Ovarian cancer metastasis: integrating insights from disparate model organisms","volume":"5","author":"Naora","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2016.05.098_bib4","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1126\/science.1207861","article-title":"Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase","volume":"334","author":"Du","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2016.05.098_bib5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/gb-2004-5-5-224","article-title":"Sirtuins: sir2-related NAD-dependent protein deacetylases","volume":"5","author":"North","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbrc.2016.05.098_bib6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature12038","article-title":"SIRT6 regulates TNF-\u03b1 secretion through hydrolysis of long-chain fatty acyl lysine","volume":"496","author":"Jiang","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2016.05.098_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrm3293","article-title":"Sirtuins as regulators of metabolism and healthspan","volume":"13","author":"Houtkooper","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2016.05.098_bib8","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1101\/gad.1467506","article-title":"Mammalian sirtuins\u2013emerging roles in physiology, aging, and calorie restriction","volume":"20","author":"Haigis","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2016.05.098_bib9","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1172\/JCI64094","article-title":"The sirtuin family\u2019s role in aging and age-associated pathologies","volume":"123","author":"Hall","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2016.05.098_bib10","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.tibs.2010.07.003","article-title":"Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling","volume":"35","author":"Verdin","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbrc.2016.05.098_bib11","unstructured":"Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, et\u00a0al, A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages, 85 (2005) 258\u2013263."},{"key":"10.1016\/j.bbrc.2016.05.098_bib12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/1471-2407-14-297","article-title":"Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection","volume":"14","author":"Wang","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbrc.2016.05.098_bib13","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ccr.2011.02.014","article-title":"SIRT3 opposes reprogramming of cancer cell metabolism through HIF1\u03b1 destabilization","volume":"19","author":"Finley","year":"2011","journal-title":"Cancer Cell."},{"key":"10.1016\/j.bbrc.2016.05.098_bib14","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/cncr.25676","article-title":"Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer","volume":"117","author":"Alhazzazi","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.bbrc.2016.05.098_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cell.2004.07.011","article-title":"Epithelial-mesenchymal transitions: twist in development and metastasis","volume":"118","author":"Kang","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2016.05.098_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbrc.2007.11.151","article-title":"Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer","volume":"367","author":"Vesuna","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2016.05.098_bib17","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1158\/0008-5472.CAN-05-3401","article-title":"N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1","volume":"66","author":"Alexander","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2016.05.098_bib18","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35001622","article-title":"Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase","volume":"403","author":"Imai","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2016.05.098_bib19","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1128\/MCB.01636-07","article-title":"Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation","volume":"27","author":"Lombard","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2016.05.098_bib20","doi-asserted-by":"crossref","first-page":"6384","DOI":"10.1128\/MCB.00426-08","article-title":"SIRT3 is a stress responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku-70","volume":"28","author":"Sundaresan","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2016.05.098_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ccr.2009.11.023","article-title":"SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress","volume":"17","author":"Kim","year":"2010","journal-title":"Cancer Cell."},{"key":"10.1016\/j.bbrc.2016.05.098_bib22","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbrc.2013.11.068","article-title":"Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer","volume":"443","author":"Yang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2016.05.098_bib23","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1056\/NEJMra0805239","article-title":"Molecular basis of metastasis","volume":"359","author":"Chiang","year":"2008","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2016.05.098_bib24","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1126\/science.1164853","article-title":"Cancer. The metastasis cascade","volume":"321","author":"Klein","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2016.05.098_bib25","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1073\/pnas.1520045113","article-title":"SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions","volume":"113","author":"Bhardwaj","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2016.05.098_bib26","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1158\/0008-5472.CAN-12-1033","article-title":"TWIST1 is an ERK1\/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells","volume":"72","author":"Weiss","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2016.05.098_bib27","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1074\/jbc.M113.528026","article-title":"Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition","volume":"289","author":"Villarejo","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.05.098_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/path.4443","article-title":"MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with goodprognosis in epithelial ovarian cancer","volume":"235","author":"Sun","year":"2015","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.bbrc.2016.05.098_bib29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/onc.2015.84","article-title":"miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin","volume":"35","author":"Zhu","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2016.05.098_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ccr.2008.06.005","article-title":"Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence","volume":"14","author":"Ansieau","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2016.05.098_bib31","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1245\/ASO.2005.04.010","article-title":"Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer","volume":"12","author":"Martin","year":"2005","journal-title":"Ann. Surg. Oncol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16308063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16308063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T02:36:12Z","timestamp":1617330972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X16308063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0006291X16308063"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.05.098","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down-regulation of SIRT3 promotes ovarian carcinoma metastasis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.05.098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}