{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:26:19Z","timestamp":1767651979697},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.bbrc.2016.05.162","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T04:14:09Z","timestamp":1464927249000},"page":"560-565","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Acetylshikonin from Zicao exerts antifertility effects at high dose in rats by suppressing the secretion of GTH"],"prefix":"10.1016","volume":"476","author":[{"given":"Yu","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qisen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banghao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.05.162_bib1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/clpt.2013.204","article-title":"Antiobesity pharmacotherapy: new drugs and emerging targets","volume":"95","author":"Kim","year":"2014","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2016.05.162_bib2","doi-asserted-by":"crossref","first-page":"508972","DOI":"10.1155\/2012\/508972","article-title":"The molecular basis of wound healing processes induced by lithospermi radix: a proteomics and biochemical analysis","volume":"2012","author":"Hsiao","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.bbrc.2016.05.162_bib3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jep.2014.04.038","article-title":"Arnebin-1 promotes the angiogenesis of human umbilical vein endothelial cells and accelerates the wound healing process in diabetic rats","volume":"154","author":"Zeng","year":"2014","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2016.05.162_bib4","doi-asserted-by":"crossref","first-page":"e0146884","DOI":"10.1371\/journal.pone.0146884","article-title":"Acetylshikonin from zicao prevents obesity in rats on a high-fat diet by inhibiting lipid accumulation and inducing lipolysis","volume":"11","author":"Su","year":"2016","journal-title":"Plos One"},{"key":"10.1016\/j.bbrc.2016.05.162_bib5","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.2174\/09298673113209990008","article-title":"Traditional chinese medicine remedy to jury: the pharmacological basis for the use of shikonin as an anticancer therapy","volume":"20","author":"Andujar","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbrc.2016.05.162_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ptr.1100","article-title":"Cellular pharmacology studies of shikonin derivatives","volume":"16","author":"Chen","year":"2002","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bbrc.2016.05.162_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0010-7824(81)90101-3","article-title":"The antigonadotropic activity of Lithospermum ruderale. II. The inhibition of LRF-induced gonadotropin release in\u00a0vitro","volume":"23","author":"Findley","year":"1981","journal-title":"Contraception"},{"key":"10.1016\/j.bbrc.2016.05.162_bib8","first-page":"34","article-title":"Study on the antifertility effect of Lithospermum erythrorhizon","volume":"01","author":"Ma","year":"1993","journal-title":"Acta Acad. Med. Sandong"},{"key":"10.1016\/j.bbrc.2016.05.162_bib9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0003-9861(84)90379-5","article-title":"Phosphatidic acid and the calcium-dependent actions of gonadotropin-releasing hormone in pituitary gonadotrophs","volume":"231","author":"Kiesel","year":"1984","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2016.05.162_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0303-7207(01)00469-5","article-title":"Gonadotropic control of ovarian follicular growth and development","volume":"179","author":"Hillier","year":"2001","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.bbrc.2016.05.162_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.13602","article-title":"Exocytosis in non-neuronal cells","author":"Thorn","year":"2016","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2016.05.162_bib12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1126\/science.1097196","article-title":"Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs","volume":"304","author":"Tucker","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2016.05.162_bib13","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1248\/yakushi1947.95.11_1376","article-title":"Antimicrobial activity of Lithospermum erythrorhizon callus cultures (author\u2019s transl)","volume":"95","author":"Tabata","year":"1975","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.bbrc.2016.05.162_bib14","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1248\/cpb.25.2392","article-title":"Antitumor activity of shikonin and its derivatives","volume":"25","author":"Sankawa","year":"1977","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.bbrc.2016.05.162_bib15","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1021\/np50045a014","article-title":"A\u00a0comparative study on anti-inflammatory activities of the enantiomers, shikonin and alkannin","volume":"49","author":"Tanaka","year":"1986","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.bbrc.2016.05.162_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jep.2009.03.019","article-title":"Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in\u00a0vivo models","volume":"124","author":"Akkol","year":"2009","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2016.05.162_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1749-6632.2010.05660.x","article-title":"The role of gonadotropins in the follicular phase","volume":"1205","author":"Messinis","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbrc.2016.05.162_bib18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0010-7824(80)90132-8","article-title":"The antigonadotropic activity of Lithospermum ruderale I. The lack of steroid-like activity at the receptor level","volume":"21","author":"Findley","year":"1980","journal-title":"Contraception"},{"key":"10.1016\/j.bbrc.2016.05.162_bib19","doi-asserted-by":"crossref","first-page":"C547","DOI":"10.1152\/ajpcell.00333.2002","article-title":"Synaptotagmin I increases the probability of vesicle fusion at low [Ca2+] in pituitary cells","volume":"284","author":"Kreft","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbrc.2016.05.162_bib20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/26412","article-title":"Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution","volume":"395","author":"Sutton","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2016.05.162_bib21","doi-asserted-by":"crossref","first-page":"23667","DOI":"10.1074\/jbc.270.40.23667","article-title":"Ca2+ regulates the interaction between synaptotagmin and syntaxin 1","volume":"270","author":"Chapman","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.05.162_bib22","doi-asserted-by":"crossref","first-page":"8630","DOI":"10.1074\/jbc.M211889200","article-title":"High resolution structure, stability, and synaptotagmin binding of a truncated neuronal SNARE complex","volume":"278","author":"Ernst","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.05.162_bib23","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1074\/jbc.C200692200","article-title":"Mechanism of calcium-independent synaptotagmin binding to target SNAREs","volume":"278","author":"Rickman","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.05.162_bib24","article-title":"Long-term systemic toxicity of shikonin derivatives in Wistar rats","author":"Su","year":"2013","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.bbrc.2016.05.162_bib25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0950-3552(05)80130-0","article-title":"The differential effects of FSH and LH on the human ovary","volume":"7","author":"Rabinovici","year":"1993","journal-title":"Baillieres Clin. Obstet. Gynaecol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16309123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16309123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T12:27:57Z","timestamp":1536668877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X16309123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0006291X16309123"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.05.162","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acetylshikonin from Zicao exerts antifertility effects at high dose in rats by suppressing the secretion of GTH","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.05.162","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}