{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:40:22Z","timestamp":1787992822647,"version":"build-2784847793"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBH-Z12216"],"award-info":[{"award-number":["LBH-Z12216"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"publisher","award":["20122307110002"],"award-info":[{"award-number":["20122307110002"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004027","name":"Postdoctoral Foundation of Hei Long Jiang Province","doi-asserted-by":"publisher","award":["LBH-Q15079"],"award-info":[{"award-number":["LBH-Q15079"]}],"id":[{"id":"10.13039\/501100004027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2013M540304"],"award-info":[{"award-number":["2013M540304"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501998"],"award-info":[{"award-number":["81501998"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401146"],"award-info":[{"award-number":["81401146"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2013G1002"],"award-info":[{"award-number":["2013G1002"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["QC2013C089"],"award-info":[{"award-number":["QC2013C089"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["20132307120030"],"award-info":[{"award-number":["20132307120030"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.bbrc.2016.06.051","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T08:30:18Z","timestamp":1466843418000},"page":"541-547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["miR-483-3p regulates hyperglycaemia-induced cardiomyocyte apoptosis in transgenic mice"],"prefix":"10.1016","volume":"477","author":[{"given":"Yu","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bbrc.2016.06.051_bib1","doi-asserted-by":"crossref","first-page":"C1244","DOI":"10.1152\/ajpcell.00137.2012","article-title":"miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in the type 1 diabetic heart","volume":"303","author":"Baseler","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"5","key":"10.1016\/j.bbrc.2016.06.051_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098044","article-title":"FLOS puerariae extract prevents myocardial apoptosis via attenuation oxidative stress in streptozotocin-induced diabetic MICE","volume":"9","author":"Yu","year":"2014","journal-title":"PLOS One."},{"issue":"25","key":"10.1016\/j.bbrc.2016.06.051_bib3","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","article-title":"Diabetic cardiomyopathy revisited","volume":"115","author":"Abel","year":"2007","journal-title":"Circulation."},{"issue":"1","key":"10.1016\/j.bbrc.2016.06.051_bib4","article-title":"MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy","volume":"5","author":"Li","year":"2014","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bbrc.2016.06.051_bib5","first-page":"977","article-title":"The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus","volume":"329","author":"Control T D, Complications Trial Research Group","year":"1993","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bbrc.2016.06.051_bib6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/ALN.0b013e31817dced3","article-title":"Hyperglycemia and acute coronary syndrome: a scientific statement from the American heart association diabetes committee of the council on nutrition, physical activity, and metabolism","volume":"109","author":"Deedwania","year":"2008","journal-title":"Anesthesiology"},{"issue":"3\/4","key":"10.1016\/j.bbrc.2016.06.051_bib7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.2119\/molmed.2010.00114","article-title":"Inhibition of aldehydedehydrogenase 2 by oxidative stress is associated with cardiac dysfunction in diabetic rats","volume":"17","author":"Wang","year":"2011","journal-title":"Mol. Med."},{"issue":"22","key":"10.1016\/j.bbrc.2016.06.051_bib8","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1161\/01.CIR.101.22.2618","article-title":"High glucoseinduced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal kinase and caspase-3","volume":"101","author":"Ho","year":"2000","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.bbrc.2016.06.051_bib9","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.jacc.2006.07.022","article-title":"Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial[J]","volume":"48","author":"Cai","year":"2006","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"issue":"10","key":"10.1016\/j.bbrc.2016.06.051_bib10","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.2337\/diabetes.50.10.2363","article-title":"Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death","volume":"50","author":"Fiordaliso","year":"2001","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.bbrc.2016.06.051_bib11","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.yjmcc.2004.07.008","article-title":"Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats","volume":"37","author":"Fiordaliso","year":"2004","journal-title":"J.\u00a0Mol. Cell Cardiol."},{"issue":"6","key":"10.1016\/j.bbrc.2016.06.051_bib12","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.2337\/diabetes.51.6.1938","article-title":"Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway","volume":"51","author":"Cai","year":"2002","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.bbrc.2016.06.051_bib13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/cvr\/cvp189","article-title":"Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes","volume":"84","author":"Ying Li","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"19","key":"10.1016\/j.bbrc.2016.06.051_bib14","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1016\/j.febslet.2011.08.039","article-title":"MiR-483-5p controls angiogenesis in\u00a0vitro and targets serum response factor","volume":"585","author":"Qiao","year":"2011","journal-title":"FEBS Lett."},{"issue":"4\/6","key":"10.1016\/j.bbrc.2016.06.051_bib15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000218169","article-title":"MicroRNAs in diabetes: tiny players in big disease","volume":"23","author":"Pandey","year":"2009","journal-title":"Cell Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.bbrc.2016.06.051_bib16","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1399-0004.2008.01076.x","article-title":"MicroRNAs in development and disease","volume":"74","author":"Em Erson","year":"2008","journal-title":"Clin. Genet."},{"issue":"7","key":"10.1016\/j.bbrc.2016.06.051_bib17","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.2337\/db11-0082","article-title":"Diabetes complications: the microRNA perspective","volume":"60","author":"Kantharidis","year":"2011","journal-title":"Diabetes"},{"issue":"7224","key":"10.1016\/j.bbrc.2016.06.051_bib18","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/nature07511","article-title":"MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts","volume":"456","author":"Thum","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbrc.2016.06.051_bib19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/dmrr.1054","article-title":"miR133a regulates cardiomyocyte hypertrophy in diabetes","volume":"26","author":"Feng","year":"2000","journal-title":"Diabetes Metab. Res. Rev."},{"issue":"16","key":"10.1016\/j.bbrc.2016.06.051_bib20","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1016\/j.febslet.2010.07.027","article-title":"miR-1\/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes","volume":"584","author":"Shan","year":"2010","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.bbrc.2016.06.051_bib21","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.bbrc.2008.09.025","article-title":"Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1","volume":"376","author":"Yu","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.bbrc.2016.06.051_bib22","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","article-title":"A\u00a0mammalian microRNA expression Atlas based on small RNA library sequencing","volume":"129","author":"Landgraf","year":"2007","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bbrc.2016.06.051_bib23","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/jcmm.12293","article-title":"Overexpression of miR-483-5p\/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-\u03b2 stimulated HSCs in transgenic mice","volume":"18","author":"Li","year":"2014","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2016.06.051_bib24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.yjmcc.2014.06.008","article-title":"Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system","volume":"75","author":"Kemp","year":"2014","journal-title":"J.\u00a0Mol. Cell Cardiol."},{"issue":"8","key":"10.1016\/j.bbrc.2016.06.051_bib25","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/ejhf.116","article-title":"Circulating microRNAs for predicting and monitoring response to mechanical circulatory support from a left ventricular assist device","volume":"16","author":"Morley-Smith","year":"2014","journal-title":"Eur. J. Heart Fail."},{"issue":"6","key":"10.1016\/j.bbrc.2016.06.051_bib26","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1136\/heart.86.6.693","article-title":"Insulin-like growth factor I and II preserve myocardial structure in postinfarct swine","volume":"86","author":"Kotlyar","year":"2001","journal-title":"Heart"},{"issue":"2","key":"10.1016\/j.bbrc.2016.06.051_bib27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0008-6363(96)00212-X","article-title":"Insulin-like growth factor-II delays myocardial infarction in experimental coronary artery occlusion","volume":"33","author":"Vogt","year":"1997","journal-title":"Cardiovasc Res."},{"issue":"5","key":"10.1016\/j.bbrc.2016.06.051_bib28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jdiacomp.2012.05.012","article-title":"IGF2BP2 and IGF2 genetic effects in diabetes and diabetic nephropathy","volume":"26","author":"Gu","year":"2012","journal-title":"J.\u00a0Diabetes Complicat."},{"issue":"3","key":"10.1016\/j.bbrc.2016.06.051_bib29","doi-asserted-by":"crossref","DOI":"10.1006\/bbrc.2000.2550","article-title":"IGF-1 regulates apoptosis of cardiac myocyte induced by osmotic-stress","volume":"270","author":"Morales","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.bbrc.2016.06.051_bib30","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bbrc.2016.06.051_bib31","doi-asserted-by":"crossref","first-page":"67266","DOI":"10.1371\/journal.pone.0067266","article-title":"IGF signaling is required for cardiomyocyte proliferation during zebrafish heart development and regeneration","volume":"26","author":"Huang","year":"2013","journal-title":"PLOS One."},{"issue":"4","key":"10.1016\/j.bbrc.2016.06.051_bib32","doi-asserted-by":"crossref","first-page":"624","DOI":"10.4161\/auto.23577","article-title":"Regulation of interplay between autophagy and apoptosis in the diabetic heart: new role of AMPK","volume":"9","author":"Zou Mh","year":"2013","journal-title":"Autophagy"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1630969X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1630969X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:57:16Z","timestamp":1777377436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X1630969X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0006291X1630969X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.06.051","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-483-3p regulates hyperglycaemia-induced cardiomyocyte apoptosis in transgenic mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.06.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}