{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:30:21Z","timestamp":1791268221656,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1504325"],"award-info":[{"award-number":["U1504325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31101779"],"award-info":[{"award-number":["31101779"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003172","name":"Henan University of Science and Technology","doi-asserted-by":"publisher","award":["13490001"],"award-info":[{"award-number":["13490001"]}],"id":[{"id":"10.13039\/501100003172","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003172","name":"Henan University of Science and Technology","doi-asserted-by":"publisher","award":["13310008"],"award-info":[{"award-number":["13310008"]}],"id":[{"id":"10.13039\/501100003172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.bbrc.2016.07.093","type":"journal-article","created":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T17:06:56Z","timestamp":1469293616000},"page":"540-545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Effects and mechanisms of melatonin on the proliferation and neural differentiation of PC12\u00a0cells"],"prefix":"10.1016","volume":"478","author":[{"given":"Yumei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongxia","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.07.093_bib1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/jpi.12292","article-title":"The neuroprotective and anti-apoptotic effects of melatonin on hemolytic hyperbilirubinemia-induced oxidative brain damage","volume":"60","author":"Pazar","year":"2016","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.bbrc.2016.07.093_bib2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/jpi.12278","article-title":"Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats","volume":"59","author":"Chen","year":"2015","journal-title":"J.\u00a0PinealRes."},{"key":"10.1016\/j.bbrc.2016.07.093_bib3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/jpi.12078","article-title":"Melatonin attenuates methamphetamine-induced disturbances in mitochondrial dynamics and degeneration in neuroblastoma SH-SY5Y cells","volume":"55","author":"Parameyong","year":"2013","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.bbrc.2016.07.093_bib4","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.2174\/1871527313666140806160400","article-title":"The Role of melatonin in multiple sclerosis, huntington\u2019s disease and cerebral ischemia","volume":"13","author":"Scribano","year":"2014","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.bbrc.2016.07.093_bib5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/1756285611406166","article-title":"Therapeutic potential of melatonin and its analogs in Parkinson's disease: focus on sleep and neuroprotection","volume":"4","author":"Srinivasan","year":"2011","journal-title":"Ther. Adv. Neurol. Disord."},{"issue":"3","key":"10.1016\/j.bbrc.2016.07.093_bib6","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bbrc.2016.04.108","article-title":"Effects and mechanisms of melatonin on neural differentiation of induced pluripotent stem cells, Biochem","volume":"474","author":"Shu","year":"2016","journal-title":"Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2016.07.093_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0304-3940(96)13035-4","article-title":"Effects of melatonin on the proliferation and differentiation of human neuroblastoma cells in culture","volume":"216","author":"Cos","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2016.07.093_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0006-8993(97)00549-0","article-title":"Melatonin suppression of PC12 cell growth and death","volume":"768","author":"Roth","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2016.07.093_bib9","first-page":"473","article-title":"Ion channel and receptor properties of pheochromocytoma (PC12 cells): a model for neuro toxicological studies","volume":"12","author":"Shafer","year":"1991","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbrc.2016.07.093_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2045-8118-9-8","article-title":"In\u00a0vitro effects of fetal rat cerebrospinal fluid on viability and neuronal differentiation of PC12 cells","volume":"9","author":"Nabiuni","year":"2012","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.bbrc.2016.07.093_bib11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0006-8993(98)01262-1","article-title":"Ultrastructural confirmation of neuronal protection by melatonin against the neuro toxin 6-hydroxydopamine cell damage","volume":"818","author":"Mayo","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2016.07.093_bib12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1600-079X.2004.00164.x","article-title":"Melatonin reduces amyloid \u03b2-induced apoptosis in pheochromocytoma (PC12) cells","volume":"37","author":"Feng","year":"2004","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.bbrc.2016.07.093_bib13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0006-8993(01)03016-5","article-title":"Melatonin-induced suppression of PC12 cell growth is mediated by its Gi coupled transmembrane receptors","volume":"919","author":"Roth","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2016.07.093_bib14","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuroscience.2014.06.026","article-title":"Melatonin enhances adult rat hippocampal progenitor cell proliferation via ERK signaling pathway through melatonin receptor","volume":"275","author":"Tocharus","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2016.07.093_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1600-079X.2007.00469.x","article-title":"Neural stem cell transplantation and melatonin treatment in a 6-hydroxydopamine model of Parkinson's disease","volume":"43","author":"Sharma","year":"2007","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.bbrc.2016.07.093_bib16","doi-asserted-by":"crossref","first-page":"e113801","DOI":"10.1371\/journal.pone.0113801","article-title":"IGF-1 promotes Brn-4 expression and neuronal differentiation of neural stem cells via the PI3K\/Akt pathway","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2016.07.093_bib17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ydbio.2009.07.043","article-title":"MAP kinase dependent cyclinE\/cdk2 activity promotes DNA replication in early sea urchin embryos","volume":"334","author":"Kisielewska","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbrc.2016.07.093_bib18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bbrc.2015.01.108","article-title":"FAM83D activates the MEK\/ERK signaling pathway and promotes cell proliferation in hepatocellular carcinoma","volume":"458","author":"Wang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2016.07.093_bib19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/jnc.12447","article-title":"Molecular features of neural stem cells enable their enrichment using pharmacological inhibitors of survival-promoting kinases","volume":"128","author":"Brazel","year":"2014","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2016.07.093_bib20","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/35074516","article-title":"ERK induces p35, a euron-specific activator of Cdk5, through induction of Egr1","volume":"3","author":"Harada","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2016.07.093_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","article-title":"Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation","volume":"80","author":"Marshall","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2016.07.093_bib22","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/ncb822","article-title":"Molecular interpretation of ERK signal duration by immediate early gene products","volume":"4","author":"Murphy","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2016.07.093_bib23","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1523\/JNEUROSCI.23-04-01416.2003","article-title":"Rho kinase inhibition enhances axonal regeneration in the injured CNS","volume":"23","author":"Fournier","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2016.07.093_bib24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jss.2009.06.002","article-title":"The effects of exogenous melatonin on peripheral nerve regeneration and collagen formation in rats","volume":"166","author":"Atik","year":"2011","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.bbrc.2016.07.093_bib25","first-page":"91","article-title":"Influence of melatonin on cell proliferation, antioxidative enzyme activities and lipid peroxidation in 3T3-L1 preadipocytes-an in\u00a0vitro study","volume":"56","author":"Zwirska-Korczala","year":"2005","journal-title":"J.\u00a0Physiol. Pharmacol."},{"key":"10.1016\/j.bbrc.2016.07.093_bib26","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuroscience.2014.06.026","article-title":"Melatonin enhances adult rat hippocampal progenitor cell proliferation via ERK signaling pathway through melatonin receptor","volume":"275","author":"Tocharus","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2016.07.093_bib27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1600-079X.2010.00794.x","article-title":"Melatonin increases proliferation of cultured neural stem cells obtained from adult mouse subventricular zone","volume":"49","author":"Sotthibundhu","year":"2010","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.bbrc.2016.07.093_bib28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1600-079X.2007.00435.x","article-title":"Melatonin influences the proliferative and differentiative activity of neural stem cells","volume":"42","author":"Moriya","year":"2007","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.bbrc.2016.07.093_bib29","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1096\/fj.03-0544fje","article-title":"Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development","volume":"18","author":"Danilova","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2016.07.093_bib30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-3940(03)00915-7","article-title":"Depolarization of PC12 cells induces neurite outgrowth and enhances nerve growth factor-induced neurite outgrowth in rats","volume":"351","author":"Howe","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2016.07.093_bib31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0076-6879(87)47111-5","article-title":"PC12 pheochromocytoma cells: culture, nerve growth factor treatment, and experimental exploitation","volume":"147","author":"Greene","year":"1987","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbrc.2016.07.093_bib32","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1073\/pnas.73.7.2424","article-title":"Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor","volume":"73","author":"Greene","year":"1976","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2016.07.093_bib33","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/S0002-9440(10)62493-5","article-title":"Microtubule-associated protein 2, a marker of neuronal differentiation, induces mitotic defects, inhibits growth of melanoma cells, and predicts metastatic potential of cutaneous melanoma","volume":"166","author":"Soltani","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2016.07.093_bib34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2174\/1573413710999140123114222","article-title":"Gene expression and behavior analysis of PC12 Cells grown on synthetic biodegradable fibrous membranes coated with natural biopolymers","volume":"10","author":"Tsai","year":"2014","journal-title":"Curr. Nanosci."},{"key":"10.1016\/j.bbrc.2016.07.093_bib35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brainresbull.2011.09.020","article-title":"Involvement of GPR12 in the induction of neurite outgrowth in PC12 cells","volume":"87","author":"Lu","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbrc.2016.07.093_bib36","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0024-3205(99)00166-6","article-title":"NGF-differentiated and undifferentiated PC12 cells vary in induction of apoptosis by ethanol","volume":"64","author":"Oberdoerster","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2016.07.093_bib37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1039\/C5MB00338E","article-title":"Chemogenomic analysis of neuronal differentiation with pathway changes in PC12 cells","volume":"12","author":"Lin","year":"2015","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.bbrc.2016.07.093_bib38","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainres.2011.12.019","article-title":"Luteolin enhances cholinergic activities in PC12 cells through ERK1\/2 and PI3K\/Akt pathways","volume":"1437","author":"Omri","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2016.07.093_bib39","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1471-4159.2004.02563.x","article-title":"Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation","volume":"90","author":"Sagara","year":"2004","journal-title":"J.\u00a0Neurochem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16312153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16312153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T17:01:54Z","timestamp":1568221314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X16312153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0006291X16312153"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.07.093","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects and mechanisms of melatonin on the proliferation and neural differentiation of PC12\u00a0cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.07.093","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}