{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:53:15Z","timestamp":1788213195869,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,27]],"date-time":"2016-08-27T00:00:00Z","timestamp":1472256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"ZACH Biotech Depot Sdn. Bhd."},{"name":"Research Management Centre UPM","award":["ZACH\/UPM\/2015"],"award-info":[{"award-number":["ZACH\/UPM\/2015"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.bbrc.2016.08.136","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T10:24:04Z","timestamp":1472811844000},"page":"1403-1408","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hypolipidemic activities of xanthorrhizol purified from centrifugal TLC"],"prefix":"10.1016","volume":"478","author":[{"given":"Seok Fang","family":"Oon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshii","family":"Nallappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Kartinee","family":"Kassim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamarina","family":"Shohaimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Shazrul Fazry","family":"Sa'ariwijaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiam Tsui","family":"Tee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yew Hoong","family":"Cheah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.08.136_bib1","first-page":"572","article-title":"International journal of medicinal plants antihyperlipidemic activity of the stem bark of Boswellia ovalifoliolata in high fat diet fed rats","volume":"107","author":"Jyothi","year":"2014","journal-title":"Int. J. Med. Plants"},{"key":"10.1016\/j.bbrc.2016.08.136_bib2","first-page":"1","article-title":"Antihyperlipidemic potential of polyphenol and glycoside rich Nerium oleander flower against triton WR-1339-induced hyperlipidemia in experimental Sprague Dawley rats","volume":"2013","author":"Gayathri","year":"2013","journal-title":"J.\u00a0Chem."},{"key":"10.1016\/j.bbrc.2016.08.136_bib3","series-title":"Ten Facts on Obesity","author":"World Health Organisation","year":"2016"},{"key":"10.1016\/j.bbrc.2016.08.136_bib4","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1089\/jmf.2008.0158","article-title":"Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes","volume":"12","author":"Rayalam","year":"2009","journal-title":"J.\u00a0Med. Food"},{"key":"10.1016\/j.bbrc.2016.08.136_bib5","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1161\/01.CIR.44.5.842","article-title":"Cholesterol production in obesity","volume":"44","author":"Miettinen","year":"1971","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2016.08.136_bib6","first-page":"227","article-title":"Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study","volume":"31","author":"Preuss","year":"2000","journal-title":"J.\u00a0Med."},{"key":"10.1016\/j.bbrc.2016.08.136_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tins.2012.12.001","article-title":"Mechanisms underlying current and future anti-obesity drugs","volume":"36","author":"Adan","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbrc.2016.08.136_bib8","series-title":"Modern Pharmacology with Clinical Applications","author":"Craig","year":"2004"},{"key":"10.1016\/j.bbrc.2016.08.136_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0030831","article-title":"Inhibition of adipogenesis and induction of apoptosis and lipolysis by stem bromelain in 3T3-L1 adipocytes","volume":"7","author":"Dave","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2016.08.136_bib10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bfopcu.2014.05.001","article-title":"Natural anti-obesity agents","volume":"52","author":"Mohamed","year":"2014","journal-title":"Bull. Fac. Pharm. Cairo Univ."},{"key":"10.1016\/j.bbrc.2016.08.136_bib11","first-page":"2021","article-title":"Nelumbo nucifera alkaloid inhibits 3T3-L1 preadipocyte differentiation and improves high-fat diet-induced obesity and body fat accumulation in rats","volume":"5","author":"Bin","year":"2011","journal-title":"J.\u00a0Med. Plants Res."},{"key":"10.1016\/j.bbrc.2016.08.136_bib12","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/ptr.3329","article-title":"Effect of mollugin on apoptosis and adipogenesis of 3T3-L1 preadipocytes","volume":"25","author":"Jun","year":"2011","journal-title":"Phyther. Res."},{"key":"10.1016\/j.bbrc.2016.08.136_bib13","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/sj.ijo.0802641","article-title":"Conjugated linoleic acid and obesity control: efficacy and mechanisms","volume":"28","author":"Wang","year":"2004","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.bbrc.2016.08.136_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/205915","article-title":"Antihyperglycemic and anti-inflammatory effects of standardized Curcuma xanthorrhiza Roxb. extract and its active compound xanthorrhizol in high-fat diet-induced obese mice","volume":"2014","author":"Kim","year":"2014","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.bbrc.2016.08.136_bib15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0024-3205(00)00619-6","article-title":"Xanthorrhizol induces endothelium-independent relaxation of rat thoracic aorta","volume":"67","author":"Campos","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2016.08.136_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/438356","article-title":"Correlation between chemical composition of Curcuma domestica and Curcuma xanthorrhiza and their antioxidant effect on human low-density lipoprotein oxidation","volume":"2012","author":"Jantan","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.bbrc.2016.08.136_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-015-0255-4","article-title":"Xanthorrhizol: a review of its pharmacological activities and anticancer properties","volume":"15","author":"Oon","year":"2015","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bbrc.2016.08.136_bib18","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s13197-014-1272-3","article-title":"Optimizing oil and xanthorrhizol extraction from Curcuma xanthorrhiza Roxb. rhizome by supercritical carbon dioxide","volume":"51","author":"Salea","year":"2014","journal-title":"J.\u00a0Food Sci. Technol."},{"key":"10.1016\/j.bbrc.2016.08.136_bib19","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.bbrc.2012.03.083","article-title":"Xanthorrhizol induced DNA fragmentation in HepG2 cells involving Bcl-2 family proteins","volume":"420","author":"Tee","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2016.08.136_bib20","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1089\/thy.2013.0194","article-title":"Effects of prostaglandin F(2\u03b1) on adipocyte biology relevant to graves' orbitopathy","volume":"23","author":"Draman","year":"2013","journal-title":"Thyroid"},{"key":"10.1016\/j.bbrc.2016.08.136_bib21","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1016\/j.febslet.2013.07.033","article-title":"LMO4 modulates proliferation and differentiation of 3T3-L1 preadipocytes","volume":"587","author":"Wang","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2016.08.136_bib22","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.nutres.2008.09.001","article-title":"Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity","volume":"28","author":"Leifert","year":"2008","journal-title":"Nutr. Res."},{"key":"10.1016\/j.bbrc.2016.08.136_bib23","doi-asserted-by":"crossref","first-page":"16656","DOI":"10.3390\/molecules191016656","article-title":"Anti-obesity effects of hispidin and alpinia zerumbet bioactives in 3T3-L1 adipocytes","volume":"19","author":"Tu","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2016.08.136_bib24","first-page":"892","article-title":"Development and validation of a liquid chromatography method for quantification of xanthorrhizol in roots of in roots of Iostephane heterophylla (Cav.) Benth ex Hemsl","volume":"909","author":"Aguilar","year":"2007","journal-title":"J.\u00a0AOAC Int."},{"key":"10.1016\/j.bbrc.2016.08.136_bib25","first-page":"145","article-title":"Centrifugally accelerated thin layer chromatography for isolation of marker compounds and bioactives","volume":"3","author":"Agrawal","year":"2015","journal-title":"J.\u00a0Phamacogn. Phytochem."},{"key":"10.1016\/j.bbrc.2016.08.136_bib26","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ymeth.2007.01.003","article-title":"The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity","volume":"42","author":"Houghton","year":"2007","journal-title":"Methods"},{"key":"10.1016\/j.bbrc.2016.08.136_bib27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1194\/jlr.M400199-JLR200","article-title":"Interaction of cholesterol with sphingosine: physicochemical characterization and impact on intestinal absorption","volume":"46","author":"Garmy","year":"2005","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.bbrc.2016.08.136_bib28","first-page":"1270","article-title":"Differences in lipid characteristics of undifferentiated and differentiated enterocytic differentiated HT29 human colonic cells","volume":"51","author":"Reynier","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2016.08.136_bib29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1139\/y97-041","article-title":"Nutrient uptake into undifferentiated and differentiated HT-29 cells in culture","volume":"75","author":"Thomson","year":"1997","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbrc.2016.08.136_bib30","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0022-2275(20)34891-4","article-title":"A\u00a0fluorescent cholesterol analog traces cholesterol absorption in hamsters and is esterified in\u00a0vivo and in\u00a0vitro","volume":"40","author":"Sparrow","year":"1999","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.bbrc.2016.08.136_bib31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1388-1981(02)00128-2","article-title":"Protein-disulfide isomerase is a component of an NBD-cholesterol monomerizing protein complex from hamster small intestine","volume":"1581","author":"Cai","year":"2002","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.bbrc.2016.08.136_bib32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/cbf.1048","article-title":"NBD-cholesterol incorporation by rat macrophages and lymphocytes: a process dependent on the activation state of the cells","volume":"22","author":"Portioli Silva","year":"2004","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.bbrc.2016.08.136_bib33","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1021\/jf0609882","article-title":"Inhibitory effect of phenolic acids on the proliferation of 3T3-L1 preadipocytes in relation to their antioxidant activity","volume":"54","author":"Hsu","year":"2006","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2016.08.136_bib34","series-title":"Effects of Bitter Melon Extracts on Adipogenesis of 3T3-L1 Adipocytes","author":"Tam","year":"2009"},{"key":"10.1016\/j.bbrc.2016.08.136_bib35","series-title":"Inhibition of Adipocyte Differentiation in 3T3-l1 Cell Line by Quercetin or Isorhamnetin","author":"Carvajal-Aldaz","year":"2012"},{"key":"10.1016\/j.bbrc.2016.08.136_bib36","series-title":"Vitamin D Metabolites Inhibit Adipocyte Differentiation in 3T3-l1 Preadipocytes","author":"Natarajan","year":"2008"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16314000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16314000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T16:13:29Z","timestamp":1749572009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X16314000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0006291X16314000"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.08.136","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypolipidemic activities of xanthorrhizol purified from centrifugal TLC","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.08.136","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}