{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:37:12Z","timestamp":1790753832816,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Science & Technology of Shandong Province","award":["ZR2014HM005"],"award-info":[{"award-number":["ZR2014HM005"]}]},{"name":"Department of Science & Technology of Shandong Province","award":["2015GSF118030"],"award-info":[{"award-number":["2015GSF118030"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.bbrc.2016.11.049","type":"journal-article","created":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T16:31:40Z","timestamp":1478968300000},"page":"536-541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin in hypopharyngeal carcinoma cells"],"prefix":"10.1016","volume":"482","author":[{"given":"Shengda","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangren","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shudong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinliang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.11.049_bib1","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.3892\/or.2015.4313","article-title":"Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma","volume":"34","author":"Zhou","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbrc.2016.11.049_bib2","doi-asserted-by":"crossref","first-page":"14628","DOI":"10.18632\/oncotarget.7403","article-title":"AB209630, a long non-coding RNA decreased expression in hypopharyngeal squamous cell carcinoma, influences proliferation, invasion, metastasis, and survival","volume":"7","author":"Zhou","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2016.11.049_bib3","doi-asserted-by":"crossref","first-page":"8632","DOI":"10.1158\/1078-0432.CCR-05-1170","article-title":"Mcl-1, vascular endothelial growth factor-R2, and 14-3-3sigma expression might predict primary response against radiotherapy and chemotherapy in patients with locally advanced squamous cell carcinomas of the head and neck","volume":"11","author":"Erovic","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2016.11.049_bib4","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1101\/gad.276725.115","article-title":"Inactivation of prosurvival Bcl-2 proteins activates Bax\/Bak through the outer mitochondrial membrane","volume":"30","author":"O'Neill","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2016.11.049_bib5","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1007\/s00018-008-8637-6","article-title":"Mcl-1 is a potential therapeutic target in multiple types of cancer","volume":"66","author":"Akgul","year":"2009","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2016.11.049_bib6","doi-asserted-by":"crossref","first-page":"e111927","DOI":"10.1371\/journal.pone.0111927","article-title":"Overexpression of Mcl-1L splice variant is associated with poor prognosis and chemoresistance in oral cancers","volume":"9","author":"Palve","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2016.11.049_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.gene.2016.04.054","article-title":"MCL-1 is the key target of adjuvant chemotherapy to reverse the cisplatin-resistance in NSCLC","volume":"587","author":"Ma","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.bbrc.2016.11.049_bib8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1124\/jpet.115.230052","article-title":"Dinaciclib, a cyclin-dependent kinase inhibitor promotes proteasomal degradation of Mcl-1 and enhances ABT-737-mediated cell death in malignant human glioma cell lines","volume":"356","author":"Jane","year":"2016","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbrc.2016.11.049_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/leu.2010.290","article-title":"The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells and is highly synergistic with cytarabine","volume":"25","author":"Walsby","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2016.11.049_bib10","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1158\/1078-0432.CCR-06-2294","article-title":"Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity","volume":"13","author":"Hussain","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2016.11.049_bib11","first-page":"473","article-title":"Expression and prognostic relevance of Mcl-1 in breast cancer","volume":"24","author":"O'Driscoll","year":"2004","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbrc.2016.11.049_bib12","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/jso.21344","article-title":"Prognostic role of myeloid cell leukemia-1 protein (Mcl-1) expression in human gastric cancer","volume":"100","author":"Likui","year":"2009","journal-title":"J.\u00a0Surg. Oncol."},{"key":"10.1016\/j.bbrc.2016.11.049_bib13","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s12032-011-0005-y","article-title":"The expression of Mcl-1 in human cervical cancer and its clinical significance","volume":"29","author":"Zhang","year":"2012","journal-title":"Med. Oncol."},{"key":"10.1016\/j.bbrc.2016.11.049_bib14","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.tips.2008.03.003","article-title":"Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology","volume":"29","author":"Wang","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbrc.2016.11.049_bib15","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/ijc.26127","article-title":"CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol","volume":"130","author":"Liu","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbrc.2016.11.049_bib16","doi-asserted-by":"crossref","first-page":"7691","DOI":"10.18632\/oncotarget.2296","article-title":"Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73","volume":"5","author":"Lam","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2016.11.049_bib17","doi-asserted-by":"crossref","first-page":"375","DOI":"10.18632\/oncotarget.1568","article-title":"A\u00a0novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine","volume":"5","author":"Walsby","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2016.11.049_bib18","first-page":"1499","article-title":"Down-regulation of Mcl-1 with antisense technology alters the effect of various cytotoxic agents used in treatment of squamous cell carcinoma of the head and neck","volume":"19","author":"Skoda","year":"2008","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbrc.2016.11.049_bib19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1158\/1541-7786.MCR-07-0080","article-title":"Down-regulation of mcl-1 by small interfering RNA sensitizes resistant melanoma cells to fas-mediated apoptosis","volume":"6","author":"Chetoui","year":"2008","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbrc.2016.11.049_bib20","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00280-008-0697-7","article-title":"Inducing apoptosis and enhancing chemosensitivity to gemcitabine via RNA interference targeting Mcl-1 gene in pancreatic carcinoma cell","volume":"62","author":"Wei","year":"2008","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.bbrc.2016.11.049_bib21","doi-asserted-by":"crossref","first-page":"16623","DOI":"10.18632\/oncotarget.3932","article-title":"Mcl-1 is an important therapeutic target for oral squamous cell carcinomas","volume":"6","author":"Maji","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2016.11.049_bib22","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1038\/sj.onc.1205511","article-title":"Physical interaction between pRb and cdk9\/cyclinT2 complex","volume":"21","author":"Simone","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2016.11.049_bib23","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0092-8674(95)90385-2","article-title":"The retinoblastoma protein and cell cycle control","volume":"81","author":"Weinberg","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2016.11.049_bib24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0014-5793(00)01809-3","article-title":"In\u00a0vivo localisation and stability of human Mcl-1 using green fluorescent protein (GFP) fusion proteins","volume":"478","author":"Akgul","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2016.11.049_bib25","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1189\/jlb.70.5.783","article-title":"BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis","volume":"70","author":"Moulding","year":"2001","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.bbrc.2016.11.049_bib26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2005.09.010","article-title":"Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapy","volume":"44","author":"Sieghart","year":"2006","journal-title":"J.\u00a0Hepatol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16319040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16319040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:04:48Z","timestamp":1692569088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X16319040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0006291X16319040"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.11.049","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin in hypopharyngeal carcinoma cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.11.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}