{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:00:50Z","timestamp":1777158050220,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.bbrc.2016.11.146","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T02:32:54Z","timestamp":1480300374000},"page":"994-1000","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Activation of EVI1 transcription by the LEF1\/\u03b2-catenin complex with p53-alteration in myeloid blast crisis of chronic myeloid leukemia"],"prefix":"10.1016","volume":"482","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7544-4034","authenticated-orcid":false,"given":"Nawin","family":"Manachai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Nakahata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash Govind","family":"Bahirvani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motomi","family":"Osato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.11.146_bib1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrc2147","article-title":"Chronic myeloid leukaemia as a model of disease evolution in human cancer","volume":"7","author":"Melo","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2016.11.146_bib2","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1182\/blood-2012-02-412890","article-title":"Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt\u2013\u03b2-catenin signaling","volume":"121","author":"Zhang","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2016.11.146_bib3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1056\/NEJMoa040258","article-title":"Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML","volume":"351","author":"Jamieson","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2016.11.146_bib4","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.ccr.2007.11.003","article-title":"Loss of beta-catenin impairs the renewal of normal and CML stem cells in\u00a0vivo","volume":"12","author":"Zhao","year":"2007","journal-title":"Cancer Cell."},{"key":"10.1016\/j.bbrc.2016.11.146_bib5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ccr.2011.12.020","article-title":"Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib","volume":"21","author":"Li","year":"2012","journal-title":"Cancer Cell."},{"key":"10.1016\/j.bbrc.2016.11.146_bib6","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1038\/onc.2014.108","article-title":"Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia","volume":"33","author":"Sato","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2016.11.146_bib7","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0092-8674(88)91175-0","article-title":"Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines","volume":"54","author":"Morishita","year":"1988","journal-title":"Cell."},{"key":"10.1016\/j.bbrc.2016.11.146_bib8","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1038\/sj.emboj.7600679","article-title":"Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression","volume":"24","author":"Yuasa","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2016.11.146_bib9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.stem.2008.06.002","article-title":"Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells","volume":"3","author":"Goyama","year":"2008","journal-title":"Cell. Stem Cell."},{"key":"10.1016\/j.bbrc.2016.11.146_bib10","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1073\/pnas.89.9.3937","article-title":"Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26","volume":"89","author":"Morishita","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2016.11.146_bib11","first-page":"788","article-title":"Increased Evi-1 expression is frequently observed in blastic crisis of chronic myelocytic leukemia","volume":"10","author":"Ogawa","year":"1996","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2016.11.146_bib12","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1038\/sj.leu.2400880","article-title":"The EVI1 gene in myeloid leukemia","volume":"11","author":"Nucifora","year":"1997","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2016.11.146_bib13","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1038\/leu.2009.49","article-title":"Bcr-Abl-mediated redox regulation of the PI3K\/AKT pathway","volume":"23","author":"Naughton","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2016.11.146_bib14","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/j.1600-0854.2011.01207.x","article-title":"Regulation of \u03b2-catenin nuclear dynamics by GSK-3\u03b2 involves a LEF1 positive feedback loop","volume":"12","author":"Jamieson","year":"2011","journal-title":"Traffic"},{"key":"10.1016\/j.bbrc.2016.11.146_bib15","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.1038\/sj.onc.1210056","article-title":"Diversity of LEF\/TCF action in development and disease","volume":"25","author":"Arce","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2016.11.146_bib16","doi-asserted-by":"crossref","first-page":"11148","DOI":"10.1074\/jbc.M116.717801","article-title":"Hematopoietic and leukemic stem cells have distinct dependence on Tcf1 and Lef1 transcription factors","volume":"291","author":"Yu","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.11.146_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1535-6108(03)00334-9","article-title":"Small-molecule antagonists of the oncogenic Tcf\/\u03b2-catenin protein complex","volume":"5","author":"Lepourcelet","year":"2004","journal-title":"Cancer Cell."},{"key":"10.1016\/j.bbrc.2016.11.146_bib18","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.1128\/MCB.21.20.6768-6781.2001","article-title":"Down-regulation of beta-catenin by activated p53","volume":"21","author":"Sadot","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2016.11.146_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0081425","article-title":"BCR-ABL1-associated reduction of beta catenin antagonist Chibby1 in chronic myeloid leukemia","volume":"8","author":"Leo","year":"2013","journal-title":"PLoS. One"},{"key":"10.1016\/j.bbrc.2016.11.146_bib20","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1038\/sj.emboj.7601485","article-title":"Bcr-Abl stabilized beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation","volume":"26","author":"Coluccia","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2016.11.146_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ccr.2005.10.015","article-title":"The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR\/ABL-regulated SET protein","volume":"8","author":"Neviani","year":"2005","journal-title":"Cancer Cell.."},{"key":"10.1016\/j.bbrc.2016.11.146_bib22","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1186624","article-title":"The Wnt\/beta-catenin pathway is required for the development of leukemia stem cells in AML","volume":"327","author":"Wang","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2016.11.146_bib23","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/mt.2009.263","article-title":"Pretranscriptional regulation of Tgf-\u03b21 by PI Polyamide prevents scarring and accelerates wound healing of the cornea after exposure to alkali","volume":"18","author":"Chen","year":"2010","journal-title":"Mol. Ther."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16320204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16320204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T05:59:36Z","timestamp":1536213576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X16320204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0006291X16320204"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.11.146","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of EVI1 transcription by the LEF1\/\u03b2-catenin complex with p53-alteration in myeloid blast crisis of chronic myeloid leukemia","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.11.146","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}