{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:49:31Z","timestamp":1790117371434,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,6]],"date-time":"2016-12-06T00:00:00Z","timestamp":1480982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cheil-nammyung Foundation Research Fund (CNF2015)"},{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["K16281"],"award-info":[{"award-number":["K16281"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.bbrc.2016.12.002","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T08:00:14Z","timestamp":1480665614000},"page":"1148-1153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cyclosporine A inhibits TGF-\u03b22-induced myofibroblasts of primary cultured human pterygium fibroblasts"],"prefix":"10.1016","volume":"482","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9395-5011","authenticated-orcid":false,"given":"Sang Il","family":"Gum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2815-5886","authenticated-orcid":false,"given":"Yeoun-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2125-6251","authenticated-orcid":false,"given":"Jae-Chang","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8489-0041","authenticated-orcid":false,"given":"Im Gyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-4552","authenticated-orcid":false,"given":"Jun Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-6551","authenticated-orcid":false,"given":"Kyoo Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8959-4033","authenticated-orcid":false,"given":"Young Jeung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.12.002_bib1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/00055735-199908000-00011","article-title":"The pathogenesis of pterygia","volume":"10","author":"Coroneo","year":"1999","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/eye.1989.31","article-title":"Pathogenesis of pterygium","volume":"3","author":"Hill","year":"1989","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.bbrc.2016.12.002_bib3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3109\/02713689408999878","article-title":"Immunohistochemical evidence that human pterygia originate from an invasion of vimentin-expressing altered limbal epithelial basal cells","volume":"13","author":"Dushku","year":"1994","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.bbrc.2016.12.002_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S1542-0124(12)70103-9","article-title":"The pathogenesis of pterygium: current concepts and their therapeutic implications","volume":"6","author":"Chui","year":"2008","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bbrc.2016.12.002_bib5","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/bjo.77.11.734","article-title":"Pterygium as an early indicator of ultraviolet insolation: a hypothesis","volume":"77","author":"Coroneo","year":"1993","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0002-9394(60)90245-2","article-title":"Pterygium: its incidence, heredity and etiology","volume":"50","author":"Hilgers","year":"1960","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/bjo.68.5.347","article-title":"Pterygium in welders","volume":"68","author":"Karai","year":"1984","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0002-9394(99)00161-0","article-title":"Sun exposure and pterygium of the eye: a dose-response curve","volume":"128","author":"Threlfall","year":"1999","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib9","first-page":"CD011349","article-title":"Conjunctival autograft for pterygium","volume":"2","author":"Clearfield","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbrc.2016.12.002_bib10","first-page":"23","article-title":"Amniotic membrane transplantation for primary pterygium surgery","volume":"3","author":"Katbaab","year":"2008","journal-title":"J.\u00a0Ophthalmic Vis. Res."},{"key":"10.1016\/j.bbrc.2016.12.002_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00004397-199903910-00004","article-title":"Current options in pterygium management","volume":"39","author":"Hoffman","year":"1999","journal-title":"Int. Ophthalmol. Clin."},{"key":"10.1016\/j.bbrc.2016.12.002_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ophtha.2012.06.066","article-title":"Options and adjuvants in surgery for pterygium: a report by the American Academy of Ophthalmology","volume":"120","author":"Kaufman","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbrc.2016.12.002_bib13","first-page":"465","article-title":"Mitomycin C in pterygium treatment","volume":"9","author":"Martins","year":"2016","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0039-6257(02)00463-0","article-title":"The treatment of pterygium","volume":"48","author":"Hirst","year":"2003","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib15","first-page":"3043","article-title":"Efficiency and safety of subconjunctival injection of anti-VEGF agent - bevacizumab - in treating dry eye","volume":"9","author":"Jiang","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bbrc.2016.12.002_bib16","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/path.1427","article-title":"The myofibroblast in wound healing and fibrocontractive diseases","volume":"200","author":"Gabbiani","year":"2003","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib17","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","article-title":"Epithelial-mesenchymal transition and its implications for fibrosis","volume":"112","author":"Kalluri","year":"2003","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2016.12.002_bib18","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1006\/clim.2001.5008","article-title":"Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment","volume":"99","author":"Sime","year":"2001","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib19","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000055648","article-title":"Epitheliomesenchymal transdifferentiation of cultured RPE cells","volume":"33","author":"Lee","year":"2001","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.bbrc.2016.12.002_bib20","first-page":"2301","article-title":"TGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag","volume":"43","author":"Wormstone","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbrc.2016.12.002_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0065-1281(96)80038-9","article-title":"Immunohistochemical localization of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor-beta and tumor necrosis factor-alpha in the pterygium","volume":"98","author":"Kria","year":"1996","journal-title":"Acta Histochem."},{"key":"10.1016\/j.bbrc.2016.12.002_bib22","series-title":"Elucidating the Regulatory Mechanisms of Pterygium","year":"2013"},{"key":"10.1016\/j.bbrc.2016.12.002_bib23","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/s004170050321","article-title":"Efficacy of subconjunctival cyclosporin-containing microspheres on keratoplasty rejection in the rabbit","volume":"237","author":"de Rojas Silva","year":"1999","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/ICO.0000000000000291","article-title":"Topical cyclosporine in corneal transplantation","volume":"34","author":"Ziaei","year":"2015","journal-title":"Cornea"},{"key":"10.1016\/j.bbrc.2016.12.002_bib25","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.4049\/jimmunol.142.9.3286","article-title":"Cyclosporin A-mediated inhibition of mitogen-induced gene transcription is specific for the mitogenic stimulus and cell type","volume":"142","author":"Gunter","year":"1989","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib26","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2147\/OPTH.S19469","article-title":"The effect of topical 0.05% cyclosporine on recurrence following pterygium surgery","volume":"5","author":"Turan-Vural","year":"2011","journal-title":"Clin. Ophthalmol."},{"issue":"Suppl 7","key":"10.1016\/j.bbrc.2016.12.002_bib27","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.5301\/ejo.5000004","article-title":"Topical cyclosporine A administration after pterygium surgery","volume":"22","author":"Ozulken","year":"2012","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib28","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0181-5512(08)74384-5","article-title":"Effectiveness of topical cyclosporin A treatment after excision of primary pterygium and limbal conjunctival autograft","volume":"31","author":"Aydin","year":"2008","journal-title":"J.\u00a0Fr. Ophtalmol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1159\/000151740","article-title":"Topical cyclosporine A in the prevention of pterygium recurrence","volume":"222","author":"Yalcin Tok","year":"2008","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.bbrc.2016.12.002_bib30","first-page":"2154","article-title":"Regulation of collagenase, stromelysin, and urokinase-type plasminogen activator in primary pterygium body fibroblasts by inflammatory cytokines","volume":"41","author":"Solomon","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbrc.2016.12.002_bib31","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1097\/ICO.0000000000000477","article-title":"Cyclosporine A downregulates MMP-3 and MMP-13 expression in cultured pterygium fibroblasts","volume":"34","author":"Kim","year":"2015","journal-title":"Cornea"},{"key":"10.1016\/j.bbrc.2016.12.002_bib32","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.bbrc.2016.12.002_bib33","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jcma.2016.05.003","article-title":"Evaluation of transforming growth factor-beta1 gene expression in pterygium tissue of atopic patients","volume":"79","author":"Shayegan","year":"2016","journal-title":"J.\u00a0Chin. Med. Assoc."},{"key":"10.1016\/j.bbrc.2016.12.002_bib34","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0161-6420(83)34594-2","article-title":"Elastodysplasia and elastodystrophy as the pathologic bases of ocular pterygia and pinguecula","volume":"90","author":"Austin","year":"1983","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbrc.2016.12.002_bib35","first-page":"348","article-title":"DNA damage in human pterygium: one-shot multiple targets","volume":"19","author":"Cimpean","year":"2013","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbrc.2016.12.002_bib36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1136\/bjo.2004.050633","article-title":"Characterisation of myofibroblasts in fibrovascular tissues of primary and recurrent pterygia","volume":"89","author":"Touhami","year":"2005","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib37","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.oraloncology.2007.07.001","article-title":"Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation","volume":"44","author":"Kellermann","year":"2008","journal-title":"Oral Oncol."},{"key":"10.1016\/j.bbrc.2016.12.002_bib38","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1038\/sj.onc.1208927","article-title":"TGF-beta and epithelial-to-mesenchymal transitions","volume":"24","author":"Zavadil","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2016.12.002_bib39","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/37.3.2918221","article-title":"Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes","volume":"37","author":"Skalli","year":"1989","journal-title":"J.\u00a0Histochem Cytochem"},{"key":"10.1016\/j.bbrc.2016.12.002_bib40","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1091\/mbc.12.9.2730","article-title":"Alpha-smooth muscle actin expression upregulates fibroblast contractile activity","volume":"12","author":"Hinz","year":"2001","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.bbrc.2016.12.002_bib41","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3341\/kjo.2015.29.6.375","article-title":"A\u00a0comparative study of topical mitomycin C, cyclosporine, and bevacizumab after primary pterygium surgery","volume":"29","author":"Hwang","year":"2015","journal-title":"Korean J. Ophthalmol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16320459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16320459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T04:49:54Z","timestamp":1692593394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X16320459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0006291X16320459"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.12.002","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclosporine A inhibits TGF-\u03b22-induced myofibroblasts of primary cultured human pterygium fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}