{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:21:33Z","timestamp":1779236493082,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Clinical and Translational Science Award","award":["R01 DK47918"],"award-info":[{"award-number":["R01 DK47918"]}]},{"name":"Clinical and Translational Science Award","award":["UL1TR000433"],"award-info":[{"award-number":["UL1TR000433"]}]},{"name":"NIH","award":["P30 DK34933"],"award-info":[{"award-number":["P30 DK34933"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.bbrc.2016.12.039","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T15:00:26Z","timestamp":1481122826000},"page":"1346-1352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis"],"prefix":"10.1016","volume":"482","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5334-7484","authenticated-orcid":false,"given":"Sapna","family":"Iyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Moons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Bishr","family":"Omary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.12.039_bib1","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1053\/j.gastro.2015.08.045","article-title":"Burden of gastrointestinal, liver, and pancreatic diseases in the United States","volume":"149","author":"Peery","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2016.12.039_bib2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.cgh.2009.07.037","article-title":"Recent developments in acute pancreatitis","volume":"7","author":"Talukdar","year":"2009","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2016.12.039_bib3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1503\/cjs.015015","article-title":"Clinical practice guideline: management of acute pancreatitis","volume":"59","author":"Greenberg","year":"2016","journal-title":"Can. J. Surg."},{"key":"10.1016\/j.bbrc.2016.12.039_bib4","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/archinte.168.6.649","article-title":"Epidemiology of alcohol-related liver and pancreatic disease in the United States","volume":"168","author":"Yang","year":"2008","journal-title":"Arch. Intern Med."},{"key":"10.1016\/j.bbrc.2016.12.039_bib5","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1053\/j.gastro.2013.01.068","article-title":"The epidemiology of pancreatitis and pancreatic cancer","volume":"144","author":"Yadav","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2016.12.039_bib6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11894-009-0016-4","article-title":"The changing character of acute pancreatitis: epidemiology, etiology, and prognosis","volume":"11","author":"Lowenfels","year":"2009","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.bbrc.2016.12.039_bib7","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00006676-200311000-00002","article-title":"The epidemiology of alcohol-induced pancreatitis","volume":"27","author":"Dufour","year":"2003","journal-title":"Pancreas"},{"key":"10.1016\/j.bbrc.2016.12.039_bib8","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/labinvest.2010.44","article-title":"Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression","volume":"90","author":"Wang","year":"2010","journal-title":"Lab. Investig."},{"key":"10.1016\/j.bbrc.2016.12.039_bib9","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0016-5085(85)80079-2","article-title":"Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin","volume":"88","author":"Niederau","year":"1985","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2016.12.039_bib10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0016-5085(89)90779-8","article-title":"Effects of the cholecystokinin receptor antagonist L-364,718 on experimental pancreatitis in mice","volume":"96","author":"Silverman","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2016.12.039_bib11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/00006676-199107000-00005","article-title":"Hyperstimulation pancreatitis in mice induced by cholecystokinin octapeptide, caerulein, and novel analogues: effect of molecular structure on potency","volume":"6","author":"Shorrock","year":"1991","journal-title":"Pancreas"},{"key":"10.1016\/j.bbrc.2016.12.039_bib12","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.yexcr.2004.05.026","article-title":"Actin overexpression parallels severity of pancreatic injury","volume":"299","author":"Zhong","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2016.12.039_bib13","first-page":"465","article-title":"Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet","volume":"79","author":"Lombardi","year":"1975","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2016.12.039_bib14","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1007\/BF01296014","article-title":"Histopathologic correlates of serum amylase activity in acute experimental pancreatitis","volume":"37","author":"Schmidt","year":"1992","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bbrc.2016.12.039_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1083\/jcb.201102142","article-title":"Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation","volume":"195","author":"Snider","year":"2011","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2016.12.039_bib16","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/hep.24203","article-title":"Fibrinogen-gamma proteolysis and solubility dynamics during apoptotic mouse liver injury: heparin prevents and treats liver damage","volume":"53","author":"Weerasinghe","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2016.12.039_bib17","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ng.413","article-title":"Mutations in PYCR1 cause cutis laxa with progeroid features","volume":"41","author":"Reversade","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2016.12.039_bib18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00018060","article-title":"Rapid determination of free proline for water-stress studies","volume":"39","author":"Bates","year":"1973","journal-title":"Plant Soil"},{"key":"10.1016\/j.bbrc.2016.12.039_bib19","doi-asserted-by":"crossref","first-page":"17626","DOI":"10.1074\/jbc.M413343200","article-title":"Proteomic profiling of hepatic endoplasmic reticulum-associated proteins in an animal model of insulin resistance and metabolic dyslipidemia","volume":"280","author":"Morand","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.12.039_bib20","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/pmic.201100558","article-title":"Comprehensive identification of novel post-translational modifications in cellular peroxiredoxin 6","volume":"12","author":"Jeong","year":"2012","journal-title":"Proteomics"},{"key":"10.1016\/j.bbrc.2016.12.039_bib21","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1177\/002215540305101012","article-title":"Clusterin expression in the early process of pancreas regeneration in the pancreatectomized rat","volume":"51","author":"Min","year":"2003","journal-title":"J.\u00a0Histochem Cytochem"},{"key":"10.1016\/j.bbrc.2016.12.039_bib22","doi-asserted-by":"crossref","first-page":"2008S","DOI":"10.1093\/jn\/138.10.2008S","article-title":"The metabolism of proline as microenvironmental stress substrate","volume":"138","author":"Phang","year":"2008","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.bbrc.2016.12.039_bib23","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/MPA.0b013e31828fddc3","article-title":"Proteomics as a systems approach to pancreatitis","volume":"42","author":"Williams","year":"2013","journal-title":"Pancreas"},{"key":"10.1016\/j.bbrc.2016.12.039_bib24","doi-asserted-by":"crossref","first-page":"e27574","DOI":"10.1371\/journal.pone.0027574","article-title":"Proteomics portrait of archival lesions of chronic pancreatitis","volume":"6","author":"Pan","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2016.12.039_bib25","doi-asserted-by":"crossref","first-page":"25179","DOI":"10.1074\/jbc.M302706200","article-title":"Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress","volume":"278","author":"Wang","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.12.039_bib26","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1002\/pmic.200800066","article-title":"Proteomic profiling in an animal model of acute pancreatitis","volume":"8","author":"Fetaud","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.bbrc.2016.12.039_bib27","doi-asserted-by":"crossref","first-page":"e45190","DOI":"10.1371\/journal.pone.0045190","article-title":"Functional specialization in proline biosynthesis of melanoma","volume":"7","author":"De Ingeniis","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2016.12.039_bib28","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.freeradbiomed.2007.10.054","article-title":"Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress","volume":"44","author":"Krishnan","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2016.12.039_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bbrc.2013.05.095","article-title":"DJ-1 cooperates with PYCR1 in cell protection against oxidative stress","volume":"436","author":"Yasuda","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2016.12.039_bib30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.nutr.012809.104638","article-title":"Proline metabolism and microenvironmental stress","volume":"30","author":"Phang","year":"2010","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bbrc.2016.12.039_bib31","doi-asserted-by":"crossref","first-page":"18846","DOI":"10.1038\/srep18846","article-title":"PYCR1 and PYCR2 interact and collaborate with RRM2B to protect cells from overt oxidative stress","volume":"6","author":"Kuo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2016.12.039_bib32","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.18632\/oncotarget.1561","article-title":"Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production","volume":"5","author":"Togashi","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2016.12.039_bib33","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1021\/bi00474a025","article-title":"Apolipoprotein J: structure and tissue distribution","volume":"29","author":"de Silva","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2016.12.039_bib34","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1432-1327.1998.2540282.x","article-title":"Clusterin overexpression in rat pancreas during the acute phase of pancreatitis and pancreatic development","volume":"254","author":"Calvo","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbrc.2016.12.039_bib35","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00006676-200103000-00004","article-title":"Expression of clusterin in pancreatic acinar cell injuries in\u00a0vivo and in\u00a0vitro","volume":"22","author":"Xie","year":"2001","journal-title":"Pancreas"},{"key":"10.1016\/j.bbrc.2016.12.039_bib36","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1083\/jcb.122.5.1119","article-title":"Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis","volume":"122","author":"French","year":"1993","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2016.12.039_bib37","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/ncb1291","article-title":"Clusterin inhibits apoptosis by interacting with activated Bax","volume":"7","author":"Zhang","year":"2005","journal-title":"Nat. Cell Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16320836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16320836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T05:26:34Z","timestamp":1568611594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X16320836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0006291X16320836"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.12.039","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.12.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}