{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T15:58:13Z","timestamp":1778428693716,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2015R1D1A1A01058467"],"award-info":[{"award-number":["NRF-2015R1D1A1A01058467"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K1421391"],"award-info":[{"award-number":["K1421391"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.bbrc.2016.12.049","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T12:20:34Z","timestamp":1481372434000},"page":"1407-1412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Toll-like receptor 4 signaling is required for clusterin-induced tumor necrosis factor-\u03b1 secretion in macrophage"],"prefix":"10.1016","volume":"482","author":[{"given":"Young-Jun","family":"Shim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo-Keung","family":"Tae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong-Ho","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Sung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sol-Yi","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bon-Hong","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.12.049_bib1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1159\/000351207","article-title":"The molecular chaperone apolipoprotein J\/clusterin as a sensor of oxidative stress: implications in therapeutic approaches \u2013 a mini-review","volume":"59","author":"Trougakos","year":"2013","journal-title":"Gerontology"},{"key":"10.1016\/j.bbrc.2016.12.049_bib2","doi-asserted-by":"crossref","first-page":"14292","DOI":"10.1016\/S0021-9258(18)77299-2","article-title":"Purification and characterization of apolipoprotein J","volume":"265","author":"de Silva","year":"1990","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.12.049_bib3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/1357-2725(95)00027-M","article-title":"Clusterin: physiologic and pathophysiologic considerations","volume":"27","author":"Rosenberg","year":"1995","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2016.12.049_bib4","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1080\/10715760600902310","article-title":"Regulation of clusterin\/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases","volume":"40","author":"Trougakos","year":"2006","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.bbrc.2016.12.049_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/sj.cdd.4401779","article-title":"Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer","volume":"13","author":"Shannan","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2016.12.049_bib6","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.bbrc.2012.03.087","article-title":"Over-expression of human clusterin increases stress resistance and extends lifespan in Drosophila melanogaster","volume":"420","author":"Lee","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2016.12.049_bib7","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1172\/JCI9037","article-title":"Apolipoprotein J\/clusterin limits the severity of murine autoimmune myocarditis","volume":"106","author":"McLaughlin","year":"2000","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2016.12.049_bib8","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1128\/MCB.22.6.1893-1902.2002","article-title":"Apolipoprotein J\/clusterin prevents a progressive glomerulopathy of aging","volume":"22","author":"Rosenberg","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2016.12.049_bib9","doi-asserted-by":"crossref","first-page":"F568","DOI":"10.1152\/ajprenal.00399.2009","article-title":"Loss of clusterin expression worsens renal ischemia-reperfusion injury","volume":"298","author":"Zhou","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbrc.2016.12.049_bib10","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/ERC-09-0140","article-title":"The clusterin paradigm in prostate and breast carcinogenesis","volume":"17","author":"Rizzi","year":"2010","journal-title":"Endocr.-Relat. Cancer"},{"key":"10.1016\/j.bbrc.2016.12.049_bib11","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1021\/bi062082v","article-title":"Effects of glycosylation on the structure and function of the extracellular chaperone clusterin","volume":"46","author":"Stewart","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2016.12.049_bib12","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.bbrc.2014.02.071","article-title":"Clusterin stimulates the chemotactic migration of macrophages through a pertussis toxin sensitive G-protein-coupled receptor and G-dependent pathways","volume":"445","author":"Kang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2016.12.049_bib13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbrc.2012.04.162","article-title":"Clusterin induces the secretion of TNF-alpha and the chemotactic migration of macrophages","volume":"422","author":"Shim","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2016.12.049_bib14","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1189\/jlb.0311110","article-title":"Clusterin induces matrix metalloproteinase-9 expression via ERK1\/2 and PI3K\/Akt\/NF-kappaB pathways in monocytes\/macrophages","volume":"90","author":"Shim","year":"2011","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.bbrc.2016.12.049_bib15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2119\/molmed.2011.00001","article-title":"Signaling of high mobility group box 1 (HMGB1) through toll-like receptor 4 in macrophages requires CD14","volume":"19","author":"Kim","year":"2013","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbrc.2016.12.049_bib16","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1189\/jlb.0106053","article-title":"Endotoxin tolerance attenuates LPS-induced TLR4 mobilization to lipid rafts: a condition reversed by PKC activation","volume":"80","author":"Cuschieri","year":"2006","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.bbrc.2016.12.049_bib17","first-page":"558","article-title":"Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex","volume":"164","author":"Ohashi","year":"2000","journal-title":"J.\u00a0Immunol. Baltim. Md. 1950"},{"key":"10.1016\/j.bbrc.2016.12.049_bib18","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1126\/science.1075565","article-title":"Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2","volume":"298","author":"Biragyn","year":"2002","journal-title":"Sci. (New York, N.Y.)"},{"key":"10.1016\/j.bbrc.2016.12.049_bib19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.brainresbull.2012.05.006","article-title":"Clusterin in neurological disorders: molecular perspectives and clinical relevance","volume":"88","author":"Charnay","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbrc.2016.12.049_bib20","doi-asserted-by":"crossref","first-page":"11828","DOI":"10.1021\/bi010135x","article-title":"Clusterin, a binding protein with a molten globule-like region","volume":"40","author":"Bailey","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2016.12.049_bib21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1093-3263(00)00138-8","article-title":"Intrinsically disordered protein","volume":"19","author":"Dunker","year":"2001","journal-title":"J.\u00a0Mol. Graph Model"},{"key":"10.1016\/j.bbrc.2016.12.049_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/128_2011_262","article-title":"Extracellular chaperones","volume":"328","author":"Dabbs","year":"2013","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.bbrc.2016.12.049_bib23","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0022-2275(20)42000-0","article-title":"Intracellular processing of apolipoprotein J precursor to the mature heterodimer","volume":"32","author":"Burkey","year":"1991","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.bbrc.2016.12.049_bib24","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1074\/jbc.M113.529271","article-title":"Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway","volume":"289","author":"Leeb","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2016.12.049_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddw188","article-title":"Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes","author":"Kang","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2016.12.049_bib26","first-page":"5299","article-title":"Semen clusterin is a novel DC-SIGN ligand","volume":"187","author":"Sabatte","year":"2011","journal-title":"J.\u00a0Immunol. Baltim. Md. 1950"},{"key":"10.1016\/j.bbrc.2016.12.049_bib27","doi-asserted-by":"crossref","first-page":"13070","DOI":"10.1074\/jbc.270.22.13070","article-title":"Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J\/clusterin","volume":"270","author":"Kounnas","year":"1995","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16320939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16320939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T21:06:19Z","timestamp":1658005579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X16320939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0006291X16320939"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.12.049","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toll-like receptor 4 signaling is required for clusterin-induced tumor necrosis factor-\u03b1 secretion in macrophage","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.12.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}