{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:10:29Z","timestamp":1775164229616,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Overseas Dispatch of PNU's Tenure-track Faculty"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.bbrc.2016.12.123","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T07:20:08Z","timestamp":1482304808000},"page":"449-455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5\u2032-AMP-activated protein kinase"],"prefix":"10.1016","volume":"483","author":[{"given":"Sunyoung","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongkeun","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wooseong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dohoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yejin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Hyun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Joo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Sik","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunjin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2016.12.123_bib1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.pop.2011.05.001","article-title":"Peptic ulcer disease","volume":"38","author":"Najm","year":"2011","journal-title":"Prim. Care"},{"key":"10.1016\/j.bbrc.2016.12.123_bib2","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1365-2036.2009.03960.x","article-title":"Systematic review: the global incidence and prevalence of peptic ulcer disease","volume":"29","author":"Sung","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2016.12.123_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-065X.2008.00677.x","article-title":"Emerging and reemerging diseases: a historical perspective","volume":"225","author":"Snowden","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbrc.2016.12.123_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000323958","article-title":"Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality","volume":"84","author":"Lau","year":"2011","journal-title":"Digestion"},{"issue":"Suppl 1","key":"10.1016\/j.bbrc.2016.12.123_bib5","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s10620-005-2800-9","article-title":"15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications","volume":"50","author":"Arakawa","year":"2005","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bbrc.2016.12.123_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1586\/egh.10.25","article-title":"Rebamipide: a gastrointestinal protective drug with pleiotropic activities","volume":"4","author":"Naito","year":"2010","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"issue":"Suppl 1","key":"10.1016\/j.bbrc.2016.12.123_bib7","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1007\/s10620-005-2809-0","article-title":"Gastro-protective agent rebamipide induces cyclooxygenease-2 (COX-2) in gastric epithelial cells","volume":"50","author":"Murata","year":"2005","journal-title":"Dig. Dis. Sci."},{"issue":"Suppl 1","key":"10.1016\/j.bbrc.2016.12.123_bib8","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1007\/s10620-005-2808-1","article-title":"Rebamipide reduces delay in gastric ulcer healing in cyclooxygenase-2-deficient mice","volume":"50","author":"Watanabe","year":"2005","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bbrc.2016.12.123_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceb.2014.09.004","article-title":"AMPK: positive and negative regulation, and its role in whole-body energy homeostasis","volume":"33","author":"Hardie","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbrc.2016.12.123_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tibs.2005.11.009","article-title":"Chutes and Ladders: the search for protein kinases that act on AMPK","volume":"31","author":"Witters","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbrc.2016.12.123_bib11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.coph.2009.11.009","article-title":"AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease","volume":"10","author":"Li","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bbrc.2016.12.123_bib12","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1194\/jlr.R025882","article-title":"AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases","volume":"53","author":"Srivastava","year":"2012","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.bbrc.2016.12.123_bib13","doi-asserted-by":"crossref","first-page":"7365","DOI":"10.18632\/oncotarget.3629","article-title":"Targeting AMPK for cancer prevention and treatment","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2016.12.123_bib14","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/joim.12268","article-title":"AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease","volume":"276","author":"Grahame Hardie","year":"2014","journal-title":"J.\u00a0Intern Med."},{"key":"10.1016\/j.bbrc.2016.12.123_bib15","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature11862","article-title":"Metabolism of inflammation limited by AMPK and pseudo-starvation","volume":"493","author":"O'Neill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2016.12.123_bib16","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.cmet.2014.06.014","article-title":"The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism","volume":"20","author":"Zhang","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2016.12.123_bib17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000331879","article-title":"Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats","volume":"88","author":"Baraka","year":"2011","journal-title":"Pharmacology"},{"key":"10.1016\/j.bbrc.2016.12.123_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bbrc.2014.09.028","article-title":"AMP-activated protein kinase activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis","volume":"453","author":"Lv","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2016.12.123_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1472-6882-10-45","article-title":"Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice","volume":"10","author":"Oyagi","year":"2010","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.bbrc.2016.12.123_bib20","first-page":"82","article-title":"Animal models in experimental gastric ulcer screening-A review","volume":"2","author":"Bongu","year":"2012","journal-title":"Int. J. Pharmacol. Screen. Methods"},{"key":"10.1016\/j.bbrc.2016.12.123_bib21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ejphar.2014.11.030","article-title":"Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity","volume":"747","author":"Jeong","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2016.12.123_bib22","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.bcp.2010.06.049","article-title":"AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38 mitogen-activated protein kinase signaling pathway","volume":"80","author":"Chang","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"Suppl 1","key":"10.1016\/j.bbrc.2016.12.123_bib23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1365-2036.18.s1.15.x","article-title":"The protective effect of rebamipide on paracellular permeability of rat gastric epithelial cells","volume":"18","author":"Joh","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2016.12.123_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4062\/biomolther.2014.103","article-title":"Protective effect of liriodendrin isolated from kalopanax pictus against gastric injury","volume":"23","author":"Sohn","year":"2015","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.bbrc.2016.12.123_bib25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1089\/dna.2014.2630","article-title":"AMPK activation inhibits expression of proinflammatory mediators through downregulation of PI3K\/p38 MAPK and NF-kappaB signaling in murine macrophages","volume":"34","author":"Huang","year":"2015","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.bbrc.2016.12.123_bib26","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00109-011-0748-0","article-title":"AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan","volume":"89","author":"Salminen","year":"2011","journal-title":"J.\u00a0Mol. Med."},{"key":"10.1016\/j.bbrc.2016.12.123_bib27","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1089\/ars.2012.5116","article-title":"The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice","volume":"20","author":"Mo","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.bbrc.2016.12.123_bib28","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.freeradbiomed.2015.06.012","article-title":"Functional polymorphisms in Nrf2: implications for human disease","volume":"88","author":"Cho","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2016.12.123_bib29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-kappaB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2016.12.123_bib30","doi-asserted-by":"crossref","first-page":"12748","DOI":"10.18632\/oncotarget.3327","article-title":"Metformin potentiates rapamycin and cisplatin in gastric cancer in mice","volume":"6","author":"Yu","year":"2015","journal-title":"Oncotarget"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16321830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X16321830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T18:30:43Z","timestamp":1536172243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X16321830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0006291X16321830"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.12.123","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5\u2032-AMP-activated protein kinase","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2016.12.123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}