{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:31:26Z","timestamp":1792657886314,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/18703-2"],"award-info":[{"award-number":["2011\/18703-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/17766-9"],"award-info":[{"award-number":["2014\/17766-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.bbrc.2017.01.074","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T14:33:01Z","timestamp":1484663581000},"page":"603-607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["The impact of Zika virus in the brain"],"prefix":"10.1016","volume":"492","author":[{"given":"Fabiele Baldino","family":"Russo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0004-1091","authenticated-orcid":false,"given":"Patricia Cristina Baleeiro","family":"Beltr\u00e3o-Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2017.01.074_bib1","volume":"46","author":"Dick","year":"1952","journal-title":"Trans. R. Soc."},{"key":"10.1016\/j.bbrc.2017.01.074_bib2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0035-9203(52)90043-6","article-title":"Zika virus. II. Pathogenicity and physical properties","volume":"46","author":"D","year":"1952","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.bbrc.2017.01.074_bib3","first-page":"487","volume":"29","author":"Musso","year":"2016","journal-title":"Zika Virus"},{"key":"10.1016\/j.bbrc.2017.01.074_bib4","series-title":"Evidence of Perinatal Transmission of Zika Virus, French Polynesia, December 2013 and February 2014","first-page":"8","author":"Besnard","year":"2014"},{"key":"10.1016\/j.bbrc.2017.01.074_bib5","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMc1604449","article-title":"Evidence of sexual transmission of Zika virus","volume":"374","author":"D'Ortenzio","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2017.01.074_bib6","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/S0140-6736(16)30775-9","article-title":"Correspondence late sexual transmission of Zika virus related to persistence in the semen","volume":"387","author":"Turmel","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2017.01.074_bib7","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1056\/NEJMoa1601824","article-title":"Zika virus infection with prolonged maternal viremia and fetal brain abnormalities","volume":"374","author":"Driggers","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2017.01.074_bib8","first-page":"8880","volume":"vol. 89","author":"Hamel","year":"2015"},{"key":"10.1016\/j.bbrc.2017.01.074_bib9","first-page":"1","volume":"vol. 3099","author":"Velho","year":"2016"},{"key":"10.1016\/j.bbrc.2017.01.074_bib10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1473-3099(16)00095-5","article-title":"Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study","volume":"6","author":"Calvet","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.bbrc.2017.01.074_bib11","series-title":"Special Report Zika Virus and Birth Defects \u2014 Reviewing the Evidence for Causality","author":"Rasmussen","year":"2016"},{"key":"10.1016\/j.bbrc.2017.01.074_bib12","first-page":"26","article-title":"Zika virus infection in pregnancy, microcephaly, and maternal and fetal health: what we think, what we know, and what we think we know","volume":"14","author":"Alvarado","year":"2016","journal-title":"Arch. Patrol. Lab. Med."},{"key":"10.1016\/j.bbrc.2017.01.074_bib13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nature18296","article-title":"The Brazilian Zika virus strain causes microcephaly","volume":"534","author":"Cugola","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2017.01.074_bib14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1618029113","article-title":"Zika virus cell tropism in the developing human brain and inhibition by azithromycin","author":"Retallack","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2017.01.074_bib15","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/S0140-6736(16)00644-9","article-title":"Acute myelitis due to Zika virus infection","volume":"387","author":"M\u00e9charles","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2017.01.074_bib16","first-page":"593","article-title":"Zika virus infects neural progenitors in the adult mouse brain and alters proliferation","volume":"19","author":"Li","year":"2016","journal-title":"Stem Cell."},{"key":"10.1016\/j.bbrc.2017.01.074_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3201\/eid2006.140138","article-title":"Zika virus, French Polynesia, South pacific, 2013","volume":"20","author":"Cao-Lormeau","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.bbrc.2017.01.074_bib18","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika virus infection in pregnant women in Rio de Janeiro","volume":"375","author":"Brasil","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2017.01.074_bib19","series-title":"Clinical Features and Neuroimaging (CT and MRI) Findings in Presumed Zika Virus Related Congenital Infection and Microcephaly: Retrospective Case Series Study","author":"De Fatima","year":"2015"},{"key":"10.1016\/j.bbrc.2017.01.074_bib20","author":"Centers for Disease Control and Prevention"},{"key":"10.1016\/j.bbrc.2017.01.074_bib21","series-title":"Practice Parameter: Evaluation of the Child with Microcephaly (An Evidence-based Review)","author":"Ashwal","year":"2009"},{"key":"10.1016\/j.bbrc.2017.01.074_bib22","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly","volume":"374","author":"Mlakar","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2017.01.074_bib23","article-title":"Autopsy and postmortem studies are concordant: pathology of Zika virus infection is neurotropic in fetuses and infants with microcephaly following transplacental transmission","author":"Schwartz","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.bbrc.2017.01.074_bib24","volume":"vol. 193","author":"Bell","year":"1971"},{"key":"10.1016\/j.bbrc.2017.01.074_bib25","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.stem.2012.05.005","article-title":"Induced pluripotent stem cells: past, present, and future","volume":"10","author":"Yamanaka","year":"2012","journal-title":"Cell Stem Cell."},{"key":"10.1016\/j.bbrc.2017.01.074_bib26","article-title":"Neural progenitor cells and their role in the development and evolutionary expansion of the neocortex","volume":"6","author":"Namba","year":"2016","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.bbrc.2017.01.074_bib27","first-page":"587","article-title":"Zika virus infects human cortical neural progenitors and attenuates their growth brief report Zika virus infects human cortical neural progenitors and attenuates their growth","volume":"18","author":"Tang","year":"2016","journal-title":"Stem Cell."},{"key":"10.1016\/j.bbrc.2017.01.074_bib28","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.aaf6116","article-title":"Zika virus\u00a0impairs growth in human neurospheres and brain organoids","volume":"352","author":"Garcez","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2017.01.074_bib29","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1462-5822.2008.01277.x","article-title":"Human TLR3 recognizes dengue virus and modulates viral replication in\u00a0vitro","volume":"11","author":"Tsai","year":"2009","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.bbrc.2017.01.074_bib30","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.stem.2016.07.019","article-title":"Zika virus NS4A and NS4B proteins deregulate akt- mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy","volume":"19","author":"Liang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2017.01.074_bib31","doi-asserted-by":"crossref","first-page":"a009076","DOI":"10.1101\/cshperspect.a009076","article-title":"Biology of the TAM receptors","volume":"5","author":"Lemke","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbrc.2017.01.074_bib32","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4103\/1673-5374.153671","article-title":"TAM receptors: two pathways to regulate adult neurogenesis","volume":"10","author":"Johnson","year":"2015","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bbrc.2017.01.074_bib33","doi-asserted-by":"crossref","first-page":"e115140","DOI":"10.1371\/journal.pone.0115140","article-title":"TAM receptors support neural stem cell survival, proliferation and neuronal differentiation","volume":"9","author":"Ji","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2017.01.074_bib34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nature17630","article-title":"TAM receptors regulate multiple features of microglial physiology","volume":"532","author":"Fourgeaud","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2017.01.074_bib35","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1002\/stem.699","article-title":"Transcriptome analysis of neural progenitor cells by a genetic dual reporter strategy","volume":"29","author":"Wang","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbrc.2017.01.074_bib36","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.stem.2016.03.012","article-title":"Expression analysis highlights AXL as a candidate Zika virus entry receptor in neural stem cells","volume":"18","author":"Nowakowski","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2017.01.074_bib37","series-title":"ZIKA Virus Elicits P53 Activation and Genotoxic Stress in Human Neural Progenitors Similar to Mutations Involved in Severe Forms of Genetic Microcephaly and P53","author":"El Ghouzzi","year":"2016"},{"key":"10.1016\/j.bbrc.2017.01.074_bib38","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.celrep.2016.05.075","article-title":"Western Zika virus in human fetal neural progenitors persists long term with partial cytopathic and limited immunogenic effects report western Zika virus in human fetal neural progenitors persists long term with partial cytopathic and limited immunogenic","volume":"15","author":"Hanners","year":"2016","journal-title":"Cell Reports"},{"key":"10.1016\/j.bbrc.2017.01.074_bib39","series-title":"Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia Article Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia","first-page":"1","author":"Onorati","year":"2016"},{"key":"10.1016\/j.bbrc.2017.01.074_bib40","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.chom.2016.09.006","article-title":"Zika virus infection induces cranial neural crest cells to produce cytokines at levels detrimental for neurogenesis","volume":"20","author":"Bayless","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbrc.2017.01.074_bib41","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrm1739","volume":"6","author":"G\u00f6tz","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2017.01.074_bib42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5607\/en.2015.24.3.177","article-title":"Roles of mTOR signaling in brain development","volume":"24","author":"Lee","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.bbrc.2017.01.074_bib43","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/jnc.12718","article-title":"PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2","volume":"130","author":"Wahane","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2017.01.074_bib44","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1038\/nprot.2014.158","article-title":"Generation of cerebral organoids from human pluripotent stem cells","volume":"9","author":"Lancaster","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2017.01.074_bib45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.stem.2016.07.017","article-title":"Neural differentiation in the third dimension: generating a human midbrain","volume":"19","author":"Marton","year":"2016","journal-title":"Cell Stem Cell."},{"key":"10.1016\/j.bbrc.2017.01.074_bib46","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.stem.2016.04.014","article-title":"Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3","volume":"19","author":"Dang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2017.01.074_bib47","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.cell.2016.04.032","article-title":"Brain-region-specific organoids using mini- bioreactors for modeling ZIKV exposure brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure","volume":"165","author":"Qian","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2017.01.074_bib48","doi-asserted-by":"crossref","first-page":"13978","DOI":"10.1523\/JNEUROSCI.2140-08.2008","article-title":"Toll-like receptor 3 is a negative\u00a0regulator of embryonic neural progenitor cell proliferation","volume":"28","author":"Lathia","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2017.01.074_bib49","doi-asserted-by":"crossref","first-page":"13033","DOI":"10.1523\/JNEUROSCI.4290-06.2007","article-title":"Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals","volume":"27","author":"Cameron","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2017.01.074_bib50","doi-asserted-by":"crossref","first-page":"34793","DOI":"10.1038\/srep34793","article-title":"Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2017.01.074_bib51","series-title":"A\u00a0Susceptible Mouse Model for Zika Virus Infection","first-page":"1","author":"Dowall","year":"2016"},{"key":"10.1016\/j.bbrc.2017.01.074_bib52","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.cell.2016.05.008","article-title":"Zika virus infection during pregnancy in mice causes placental damage and fetal demise article Zika virus infection during pregnancy in mice causes placental damage and fetal demise","volume":"165","author":"Miner","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2017.01.074_bib53","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/cr.2016.58","article-title":"Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice","volume":"26","author":"Wu","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.bbrc.2017.01.074_bib54","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1038\/emi.2016.103","article-title":"Zika virus-associated brain damage: animal models and open issues","volume":"5","author":"Di Guardo","year":"2016","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.bbrc.2017.01.074_bib55","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.cell.2016.08.004","article-title":"Vaginal exposure to Zika virus during pregnancy leads to fetal brain infection article vaginal exposure to Zika virus during pregnancy leads to fetal brain infection","volume":"166","author":"Yockey","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2017.01.074_bib56","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1242\/dev.143768","article-title":"Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage","volume":"143","author":"Shao","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2017.01.074_bib57","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1089\/scd.2016.0231","article-title":"Zika virus induced mortality and microcephaly in chicken embryos","volume":"25","author":"Goodfellow","year":"2016","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bbrc.2017.01.074_bib58","doi-asserted-by":"crossref","first-page":"12204","DOI":"10.1038\/ncomms12204","article-title":"A rhesus macaque model of Asian-lineage Zika virus infection,","volume":"7","author":"Dudley","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2017.01.074_bib59","doi-asserted-by":"crossref","first-page":"e0005023","DOI":"10.1371\/journal.pntd.0005023","article-title":"OpenZika: an IBM world community grid project to accelerate Zika virus drug discovery","volume":"10","author":"Ekins","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bbrc.2017.01.074_bib60","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nm.4184","article-title":"Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen","volume":"22","author":"Xu","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2017.01.074_bib61","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.antiviral.2016.11.023","article-title":"The FDA-approved drug sofosbuvir inhibits Zika virus infection","volume":"137","author":"Bullard-Feibelman","year":"2017","journal-title":"Antivir. Res."},{"key":"10.1016\/j.bbrc.2017.01.074_bib62","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.chom.2016.07.004","article-title":"A\u00a0screen of FDA-approved drugs for inhibitors of Zika virus infection","author":"Barrows","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbrc.2017.01.074_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2016.02.006","article-title":"The Zika outbreak of the 21st century","volume":"68","author":"Chang","year":"2016","journal-title":"J.\u00a0Autoimmun."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17301080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17301080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:21:26Z","timestamp":1757762486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X17301080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0006291X17301080"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.01.074","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of Zika virus in the brain","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.01.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}