{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T08:10:04Z","timestamp":1749975004314,"version":"3.41.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 HD073323","ES009132","HL112516","ES019689","HL129794"],"award-info":[{"award-number":["K08 HD073323","ES009132","HL112516","ES019689","HL129794"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["BGIA 20190008"],"award-info":[{"award-number":["BGIA 20190008"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["RG 349917"],"award-info":[{"award-number":["RG 349917"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.bbrc.2017.02.051","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T20:02:32Z","timestamp":1486756952000},"page":"195-200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice"],"prefix":"10.1016","volume":"485","author":[{"given":"Amrit Kumar","family":"Shrestha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananddeep","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renuka T.","family":"Menon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhagavatula","family":"Moorthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binoy","family":"Shivanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2017.02.051_bib1","doi-asserted-by":"crossref","first-page":"8185","DOI":"10.1073\/pnas.89.17.8185","article-title":"Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor","volume":"89","author":"Burbach","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2017.02.051_bib2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0026-895X(25)10014-X","article-title":"The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy","volume":"45","author":"Pollenz","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2017.02.051_bib3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0026-895X(25)09792-5","article-title":"Physicochemical and immunocytochemical analysis of the aryl hydrocarbon receptor nuclear translocator: characterization of two monoclonal antibodies to the aryl hydrocarbon receptor nuclear translocator","volume":"46","author":"Hord","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2017.02.051_bib4","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1074\/jbc.271.7.3952","article-title":"Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex","volume":"271","author":"Emi","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.02.051_bib5","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1016\/S0021-9258(20)64358-7","article-title":"Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants","volume":"266","author":"Favreau","year":"1991","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.02.051_bib6","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1093\/nar\/15.10.4179","article-title":"Characterization of xenobiotic responsive elements upstream from the drug-metabolizing cytochrome P-450c gene: a similarity to glucocorticoid regulatory elements","volume":"15","author":"Fujisawa-Sehara","year":"1987","journal-title":"Nucleic acids Res."},{"key":"10.1016\/j.bbrc.2017.02.051_bib7","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1073\/pnas.87.10.3826","article-title":"Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds","volume":"87","author":"Rushmore","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2017.02.051_bib8","first-page":"1155","article-title":"Impact of dioxin-type induction of drug-metabolizing enzymes on the metabolism of endo- and xenobiotics","volume":"55","author":"Schrenk","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2017.02.051_bib9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/10408449709021615","article-title":"Aryl hydrocarbon receptor-mediated signal transduction","volume":"27","author":"Rowlands","year":"1997","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.bbrc.2017.02.051_bib10","doi-asserted-by":"crossref","first-page":"23847","DOI":"10.1074\/jbc.R400004200","article-title":"Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer","volume":"279","author":"Nebert","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.02.051_bib11","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1515\/BC.2009.138","article-title":"The mammalian aryl hydrocarbon (Ah) receptor: from mediator of dioxin toxicity toward physiological functions in skin and liver","volume":"390","author":"Bock","year":"2009","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.02.051_bib12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2183\/pjab.86.40","article-title":"Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli","volume":"86","author":"Fujii-Kuriyama","year":"2010","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.bbrc.2017.02.051_bib13","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1074\/jbc.M110.187534","article-title":"Transcriptional factor aryl hydrocarbon receptor (Ahr) controls cardiovascular and respiratory functions by regulating the expression of the Vav3 proto-oncogene","volume":"286","author":"Sauzeau","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.02.051_bib14","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s12015-012-9384-5","article-title":"The evolving role of the aryl hydrocarbon receptor (AHR) in the normophysiology of hematopoiesis","volume":"8","author":"Lindsey","year":"2012","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.bbrc.2017.02.051_bib15","first-page":"215","article-title":"Leflunomide in clinical practice","volume":"31","author":"Pinto","year":"2006","journal-title":"Acta reumatol. port."},{"key":"10.1016\/j.bbrc.2017.02.051_bib16","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1186\/1471-2407-14-498","article-title":"The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis","volume":"14","author":"Jin","year":"2014","journal-title":"BMC cancer"},{"key":"10.1016\/j.bbrc.2017.02.051_bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1124\/jpet.112.195339","article-title":"Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells","volume":"343","author":"Jin","year":"2012","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbrc.2017.02.051_bib18","doi-asserted-by":"crossref","first-page":"e40926","DOI":"10.1371\/journal.pone.0040926","article-title":"The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells","volume":"7","author":"O'Donnell","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2017.02.051_bib19","doi-asserted-by":"crossref","first-page":"e13128","DOI":"10.1371\/journal.pone.0013128","article-title":"The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor","volume":"5","author":"O'Donnell","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2017.02.051_bib20","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1124\/mol.106.032748","article-title":"Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in\u00a0vivo and in\u00a0vitro","volume":"71","author":"Hu","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2017.02.051_bib21","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1124\/dmd.115.066084","article-title":"Leflunomide induces pulmonary and hepatic CYP1A enzymes via aryl hydrocarbon receptor","volume":"43","author":"Patel","year":"2015","journal-title":"Drug metabolism Dispos. Biol. fate Chem."},{"key":"10.1016\/j.bbrc.2017.02.051_bib22","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.freeradbiomed.2011.08.013","article-title":"Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor","volume":"51","author":"Shivanna","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2017.02.051_bib23","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00204-012-0855-x","article-title":"Differential modulation of aryl hydrocarbon receptor regulated enzymes by arsenite in the kidney, lung, and heart of C57BL\/6 mice","volume":"86","author":"Anwar-Mohamed","year":"2012","journal-title":"Archives Toxicol."},{"key":"10.1016\/j.bbrc.2017.02.051_bib24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.taap.2013.01.003","article-title":"Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice","volume":"267","author":"Shivanna","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrc.2017.02.051_bib25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0378-4274(96)03832-5","article-title":"Induction and decline of hepatic cytochromes P4501A1 and 1A2 in rats exposed to hyperoxia are not paralleled by changes in glutathione S-transferase-alpha","volume":"90","author":"Moorthy","year":"1997","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bbrc.2017.02.051_bib26","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1124\/jpet.103.059766","article-title":"Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury","volume":"310","author":"Jiang","year":"2004","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbrc.2017.02.051_bib27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1124\/jpet.111.182980","article-title":"Omeprazole attenuates hyperoxic lung injury in mice via aryl hydrocarbon receptor activation and is associated with increased expression of cytochrome P4501A enzymes","volume":"339","author":"Shivanna","year":"2011","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbrc.2017.02.051_bib28","doi-asserted-by":"crossref","first-page":"28944","DOI":"10.1074\/jbc.M800685200","article-title":"The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB","volume":"283","author":"Baglole","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.02.051_bib29","doi-asserted-by":"crossref","first-page":"43214","DOI":"10.1074\/jbc.M111.258764","article-title":"Genetic ablation of the aryl hydrocarbon receptor causes cigarette smoke-induced mitochondrial dysfunction and apoptosis","volume":"286","author":"Rico de Souza","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.02.051_bib30","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2353\/ajpath.2007.060391","article-title":"Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB","volume":"170","author":"Thatcher","year":"2007","journal-title":"Am. J. pathology"},{"key":"10.1016\/j.bbrc.2017.02.051_bib31","doi-asserted-by":"crossref","first-page":"R1136","DOI":"10.1152\/ajpregu.00315.2012","article-title":"Aryl hydrocarbon receptor agonist, leflunomide, protects the ischemic-reperfused kidney: role of tregs and stem cells","volume":"303","author":"Baban","year":"2012","journal-title":"Am. J. physiology. Regul. Integr. Comp. physiology"},{"key":"10.1016\/j.bbrc.2017.02.051_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.pharmtox.39.1.103","article-title":"Induction of cytochrome P4501A1","volume":"39","author":"Whitlock","year":"1999","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbrc.2017.02.051_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013128","article-title":"The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor","volume":"5","author":"O'Donnell","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2017.02.051_bib34","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0076-6879(90)86122-C","article-title":"DT-diaphorase: purification, properties, and function","volume":"186","author":"Lind","year":"1990","journal-title":"Methods Enzym."},{"key":"10.1016\/j.bbrc.2017.02.051_bib35","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0891-5849(00)00310-5","article-title":"Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues","volume":"29","author":"Siegel","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2017.02.051_bib36","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/S0021-9258(17)36101-X","article-title":"Purification and characterization of two isofunctional forms of NAD(P)H: quinone reductase from mouse liver","volume":"261","author":"Prochaska","year":"1986","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.02.051_bib37","doi-asserted-by":"crossref","first-page":"7200","DOI":"10.1073\/pnas.90.15.7200","article-title":"Isolation of x-ray-inducible transcripts from radioresistant human melanoma cells","volume":"90","author":"Boothman","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2017.02.051_bib38","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0891-5849(00)00306-3","article-title":"Regulation of genes encoding NAD(P)H:quinone oxidoreductases","volume":"29","author":"Jaiswal","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2017.02.051_bib39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0009-2797(00)00199-X","article-title":"NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms","volume":"129","author":"Ross","year":"2000","journal-title":"Chemico-biological Interact."},{"key":"10.1016\/j.bbrc.2017.02.051_bib40","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1038\/sj.onc.1205288","article-title":"Site-directed mutagenesis of cysteine to serine in the DNA binding region of Nrf2 decreases its capacity to upregulate antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene","volume":"21","author":"Bloom","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2017.02.051_bib41","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.taap.2011.06.018","article-title":"Prenatal administration of the cytochrome P4501A inducer, Beta-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: implications for bronchopulmonary dysplasia (BPD) in premature infants","volume":"256","author":"Couroucli","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrc.2017.02.051_bib42","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1152\/jappl.1988.64.4.1376","article-title":"Genetic differences in response to pulmonary cytochrome P-450 inducers and oxygen toxicity","volume":"64","author":"Mansour","year":"1988","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.bbrc.2017.02.051_bib43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.freeradbiomed.2015.01.019","article-title":"Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury","volume":"82","author":"Wang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2017.02.051_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0009-2797(91)90029-7","article-title":"Molecular mechanisms of quinone cytotoxicity","volume":"80","author":"O'Brien","year":"1991","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbrc.2017.02.051_bib45","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.freeradbiomed.2006.01.025","article-title":"BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2","volume":"40","author":"Das","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2017.02.051_bib46","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1165\/ajrcmb.26.2.4501","article-title":"Role of NRF2 in protection against hyperoxic lung injury in mice","volume":"26","author":"Cho","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17303212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17303212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T07:30:05Z","timestamp":1749972605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X17303212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0006291X17303212"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.02.051","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.02.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}