{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:33:01Z","timestamp":1789533181758,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.bbrc.2017.03.036","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T02:52:40Z","timestamp":1489459960000},"page":"329-335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism"],"prefix":"10.1016","volume":"486","author":[{"given":"Dan","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2017.03.036_bib1","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1016\/j.jacc.2016.02.081","article-title":"Dystrophin-deficient cardiomyopathy","volume":"67","author":"Kamdar","year":"2016","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2017.03.036_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2013-201803","article-title":"Curious case of calciphylaxis leading to acute mitral regurgitation","volume":"2014","author":"Gallimore","year":"2014","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.bbrc.2017.03.036_bib3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/ejhf.478","article-title":"Contemporary management of acute right ventricular failure: a statement from the heart failure association and the working group on pulmonary circulation and right ventricular function of the European society of cardiology","volume":"18","author":"Harjola","year":"2016","journal-title":"Eur. J. Heart Fail"},{"key":"10.1016\/j.bbrc.2017.03.036_bib4","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ijcard.2015.03.143","article-title":"Pre-hospital prediction of death or cardiovascular complications during hospitalisation and death within one year in suspected acute coronary syndrome patients","volume":"185","author":"Thang","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbrc.2017.03.036_bib5","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCRESAHA.115.306985","article-title":"Human engineered heart muscles engraft and survive long term in a rodent myocardial infarction model","volume":"117","author":"Riegler","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2017.03.036_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12916-014-0261-8","article-title":"Effects of mineralocorticoid receptor antagonists in patients with preserved ejection fraction: a meta-analysis of randomized clinical trials","volume":"13","author":"Chen","year":"2015","journal-title":"BMC Med."},{"key":"10.1016\/j.bbrc.2017.03.036_bib7","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ahj.2015.07.013","article-title":"Evaluation of a fully bioresorbable vascular scaffold in patients with coronary artery disease: design of and rationale for the ABSORB III randomized trial","volume":"170","author":"Kereiakes","year":"2015","journal-title":"Am. Heart J."},{"key":"10.1016\/j.bbrc.2017.03.036_bib8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/CIRCULATIONAHA.114.010765","article-title":"Paradoxical muscle sympathetic reflex activation in human heart failure","volume":"131","author":"Millar","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2017.03.036_bib9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2174\/1573399811666150722124958","article-title":"Good at heart: preserving cardiac metabolism during aging","volume":"12","author":"Sorriento","year":"2015","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.bbrc.2017.03.036_bib10","doi-asserted-by":"crossref","first-page":"e002423","DOI":"10.1161\/JAHA.115.002423","article-title":"Natriuretic peptides in the regulation of cardiovascular physiology and metabolic events","volume":"4","author":"Kerkela","year":"2015","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.bbrc.2017.03.036_bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10741-016-9530-2","article-title":"Mitochondrial dynamics and cell death in heart failure","volume":"21","author":"Marin-Garcia","year":"2016","journal-title":"Heart Fail Rev."},{"key":"10.1016\/j.bbrc.2017.03.036_bib12","doi-asserted-by":"crossref","first-page":"e0151845","DOI":"10.1371\/journal.pone.0151845","article-title":"Cardiovascular protective effect of metformin and telmisartan: reduction of PARP1 activity via the AMPK-PARP1 cascade","volume":"11","author":"Shang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2017.03.036_bib13","doi-asserted-by":"crossref","first-page":"e104888","DOI":"10.1371\/journal.pone.0104888","article-title":"Metformin protects cardiomyocyte from doxorubicin induced cytotoxicity through an AMP-activated protein kinase dependent signaling pathway: an in\u00a0vitro study","volume":"9","author":"Kobashigawa","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2017.03.036_bib14","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.metabol.2016.06.011","article-title":"Activation of the AMPK\/Sirt1 pathway by a leucine-metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans","volume":"65","author":"Banerjee","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.bbrc.2017.03.036_bib15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.7754\/Clin.Lab.2013.130531","article-title":"Metformin suppresses lipid accumulation in skeletal muscle by promoting fatty acid oxidation","volume":"60","author":"Wang","year":"2014","journal-title":"Clin. Lab."},{"key":"10.1016\/j.bbrc.2017.03.036_bib16","first-page":"1043","article-title":"The complex roles of mechanistic target of rapamycin in adipocytes and beyond","volume":"17","author":"Lee","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2017.03.036_bib17","doi-asserted-by":"crossref","first-page":"e0121016","DOI":"10.1371\/journal.pone.0121016","article-title":"Short- and long-term major cardiovascular adverse events in carotid artery interventions: a nationwide population-based cohort study in Taiwan","volume":"10","author":"Tsai","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2017.03.036_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fcvm.2016.00025","article-title":"Mitochondrial cardiomyopathies","volume":"3","author":"El-Hattab","year":"2016","journal-title":"Front. Cardiovasc Med."},{"key":"10.1016\/j.bbrc.2017.03.036_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/cvr\/cvn184","article-title":"Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation","volume":"80","author":"Rosca","year":"2008","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.bbrc.2017.03.036_bib20","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1006\/jmcc.2000.1266","article-title":"Abnormal mitochondrial respiration in failed human myocardium","volume":"32","author":"Sharov","year":"2000","journal-title":"J.\u00a0Mol. Cell Cardiol."},{"key":"10.1016\/j.bbrc.2017.03.036_bib21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1113\/jphysiol.2003.045104","article-title":"Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles","volume":"551","author":"Garnier","year":"2003","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bbrc.2017.03.036_bib22","doi-asserted-by":"crossref","first-page":"H522","DOI":"10.1152\/ajpheart.00357.2006","article-title":"Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells","volume":"292","author":"Prunier","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2017.03.036_bib23","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ijcard.2016.06.236","article-title":"SIRT3 in cardiovascular diseases: emerging roles and therapeutic implications","volume":"220","author":"Lu","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbrc.2017.03.036_bib24","doi-asserted-by":"crossref","first-page":"H962","DOI":"10.1152\/ajpheart.00832.2015","article-title":"Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice","volume":"310","author":"Pillai","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2017.03.036_bib25","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1089\/ars.2015.6403","article-title":"PGC-1alpha\/ERRalpha-Sirt3 pathway regulates DAergic neuronal death by directly deacetylating SOD2 and ATP synthase beta","volume":"24","author":"Zhang","year":"2016","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.bbrc.2017.03.036_bib26","first-page":"925","article-title":"Polydatin protects cardiomyocytes against myocardial infarction injury by activating Sirt3","volume":"16","author":"Zhang","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2017.03.036_bib27","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.molmet.2015.08.001","article-title":"PGC-1 coactivators in beta-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids","volume":"4","author":"Oropeza","year":"2015","journal-title":"Mol. Metab."},{"key":"10.1016\/j.bbrc.2017.03.036_bib28","doi-asserted-by":"crossref","first-page":"25207","DOI":"10.1074\/jbc.M113.489674","article-title":"Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells","volume":"288","author":"Cho","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.03.036_bib29","doi-asserted-by":"crossref","first-page":"10086","DOI":"10.1073\/pnas.0603615103","article-title":"Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha","volume":"103","author":"Arany","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2017.03.036_bib30","doi-asserted-by":"crossref","first-page":"26597","DOI":"10.1074\/jbc.M301850200","article-title":"Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells","volume":"278","author":"St-Pierre","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.03.036_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/cvr\/cvt080","article-title":"Aerobic interval training attenuates remodelling and mitochondrial dysfunction in the post-infarction failing rat heart","volume":"99","author":"Kraljevic","year":"2013","journal-title":"Cardiovasc Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1730493X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1730493X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T17:49:51Z","timestamp":1568915391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X1730493X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0006291X1730493X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.03.036","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.03.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}