{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:41:33Z","timestamp":1791348093099,"version":"4.3.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.bbrc.2017.03.098","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T18:32:34Z","timestamp":1490034754000},"page":"595-600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Reproductive toxicity provoked by titanium dioxide nanoparticles and the ameliorative role of Tiron in adult male rats"],"prefix":"10.1016","volume":"486","author":[{"given":"Ashraf M.","family":"Morgan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa A.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Noshy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bbrc.2017.03.098_bib1","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1080\/15287390902841516","article-title":"Influence of different sizes of titanium dioxide nanoparticles on hepatic and renal functions in rats with correlation to oxidative stress","volume":"72","author":"Liang","year":"2009","journal-title":"J.\u00a0Toxicol. Environ. Health Part A"},{"key":"10.1016\/j.bbrc.2017.03.098_bib2","first-page":"3937","article-title":"Histologic and apoptotic changes induced by titanium dioxide nanoparticles in the livers of rats","volume":"8","author":"Al-doaiss","year":"2013","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bbrc.2017.03.098_bib3","doi-asserted-by":"crossref","first-page":"8784","DOI":"10.1158\/0008-5472.CAN-09-2496","article-title":"Titanium dioxide nanoparticles induce DNA damage and genetic instability in\u00a0vivo in mice","volume":"69","author":"Trouiller","year":"2009","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bbrc.2017.03.098_bib4","first-page":"83","article-title":"Toxicology of air born environment and occupational particles","volume":"5","author":"Oberdorster","year":"2006","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.bbrc.2017.03.098_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tox.2012.02.016","article-title":"Oxidative stress-induced cytotoxic and genotoxic effects of nano-sized titanium dioxide particles in human HaCaT keratinocytes","volume":"296","author":"Jaeger","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.bbrc.2017.03.098_bib6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1743-8977-6-33","article-title":"Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics","volume":"6","author":"Helinor","year":"2009","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.bbrc.2017.03.098_bib7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.etap.2013.03.006","article-title":"Mitochondrial injury induced by nanosized titanium dioxide in A549 cells and rats","volume":"36","author":"Tang","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"10","key":"10.1016\/j.bbrc.2017.03.098_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1743-8977-10-15","article-title":"Titanium dioxide nanoparticles: a review of current toxicological data","volume":"15","author":"Shi","year":"2013","journal-title":"Part Fibre Toxicol."},{"issue":"3","key":"10.1016\/j.bbrc.2017.03.098_bib9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3109\/17435390.2015.1071443","article-title":"Genotoxicity and gene expression modulation of silver and titanium dioxide nanoparticles in mice","volume":"10","author":"Asare","year":"2016","journal-title":"Nanotoxicology"},{"issue":"2","key":"10.1016\/j.bbrc.2017.03.098_bib10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/oemed-2015-103161","article-title":"Markers of oxidative damage of nucleic acids and proteins among workers exposed to TiO2 (nano) particles","volume":"73","author":"Pelclova","year":"2016","journal-title":"Occup. Environ. Med."},{"issue":"1\u20132","key":"10.1016\/j.bbrc.2017.03.098_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mrgentox.2011.12.015","article-title":"Titanium dioxide particles phosphorylate histone H2AX independent of ROS production","volume":"742","author":"Toyooka","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bbrc.2017.03.098_bib12","first-page":"1959","article-title":"Downregulation of B-cell lymphoma\/leukemia-2 by overexpressed microRNA 34a enhanced titanium dioxide nanoparticle-induced autophagy in BEAS-2B cells","volume":"11","author":"Bai","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bbrc.2017.03.098_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3844\/ajptsp.2014.29.38","article-title":"Potential ameliorative role of N-acetylcysteine against testicular dysfunction induced by titanium dioxide in male albino rats","volume":"9","author":"El-kirdasy","year":"2014","journal-title":"Am. J. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.bbrc.2017.03.098_bib14","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/jbm.a.35548","article-title":"TiO2 nanoparticles-induced apoptosis of primary cultured Sertoli cells of mice","volume":"104","author":"Hong","year":"2016","journal-title":"J.\u00a0Biomed. Mater Res. A"},{"key":"10.1016\/j.bbrc.2017.03.098_bib15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jhazmat.2013.04.046","article-title":"Titanium dioxide nanoparticle-induced testicular damage, spermatogenesis suppression, and gene expression alterations in male mice","volume":"258\u2013259","author":"Gao","year":"2013","journal-title":"J.\u00a0Hazard. Mater."},{"issue":"8","key":"10.1016\/j.bbrc.2017.03.098_bib16","doi-asserted-by":"crossref","first-page":"e0159998","DOI":"10.1371\/journal.pone.0159998","article-title":"Tiron inhibits UVB-induced AP-1 Binding sites transcriptional activation on MMP-1 and MMP-3 promoters by MAPK signaling pathway in human dermal fibroblasts","volume":"11","author":"Lu","year":"2016","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.bbrc.2017.03.098_bib17","first-page":"515","article-title":"Chelation therapy and vanadium: effect on reproductive organs in rats","volume":"45","author":"Shrivastava","year":"2007","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.bbrc.2017.03.098_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.phrs.2014.11.001","article-title":"Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide","volume":"91","author":"Wong","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.bbrc.2017.03.098_bib19","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.etap.2014.01.014","article-title":"Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring","volume":"37","author":"Mohammadipour","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbrc.2017.03.098_bib20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.reprotox.2005.06.004","article-title":"Aluminum-induced maternal and developmental toxicity and oxidative stress in rat brain: response to combined administration of Tiron and glutathione","volume":"21","author":"Sharma","year":"2006","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.bbrc.2017.03.098_bib21","series-title":"Applied Animal Reproduction","first-page":"158","author":"Bearden","year":"1997"},{"key":"10.1016\/j.bbrc.2017.03.098_bib22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1590\/S1415-47572002000300005","article-title":"Comparison between the micronucleus frequencies of kidney and gill erythrocytes in tilapia fish, following mitomycin C treatment","volume":"25","author":"Palhares","year":"2002","journal-title":"Genet. Molec. Biol."},{"key":"10.1016\/j.bbrc.2017.03.098_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ntt.2015.05.005","article-title":"Influence of green tea extract on oxidative damage and apoptosis induced by deltamethrin in rat brain","volume":"50","author":"Ogaly","year":"2015","journal-title":"Neurotoxicol Teratol."},{"key":"10.1016\/j.bbrc.2017.03.098_bib24","series-title":"Theory and Practice of Histological Techniques","first-page":"473","author":"Bancroft","year":"2008"},{"key":"10.1016\/j.bbrc.2017.03.098_bib25","series-title":"Carleton's Histological Techniques","author":"Dury","year":"1980"},{"issue":"3","key":"10.1016\/j.bbrc.2017.03.098_bib26","first-page":"781","article-title":"Effect of pubertal nano-TiO2 exposure on testosterone synthesis and spermatogenesis in mice","volume":"88","author":"Jia","year":"2013","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.bbrc.2017.03.098_bib27","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s12010-014-1299-y","article-title":"Cytotoxic and genotoxic effects of titanium dioxide nanoparticles in testicular cells of male Wistar rat","volume":"175","author":"Meena","year":"2014","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.bbrc.2017.03.098_bib28","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2164\/jandrol.108.005132","article-title":"Oxidative stress: a common factor in testicular dysfunction","volume":"29","author":"Turner","year":"2008","journal-title":"J.\u00a0Androl."},{"key":"10.1016\/j.bbrc.2017.03.098_bib29","first-page":"865","article-title":"Toxic impact of titanium dioxide (TiO2) in male albino rats with special reference to its effect on reproductive system","volume":"6","author":"El-Sharkawy","year":"2010","journal-title":"J.\u00a0Am. Sci."},{"key":"10.1016\/j.bbrc.2017.03.098_bib30","first-page":"570","article-title":"Comparative effectiveness of CaNa3DTPA and Tiron along with \u03b1-tocopherol against beryllium-induced biochemical alterations in rats","volume":"42","author":"Mathur","year":"2004","journal-title":"Indian J. Exp. Biol."},{"issue":"3","key":"10.1016\/j.bbrc.2017.03.098_bib31","first-page":"781","article-title":"Effect of pubertal nano-TiO2 exposure on testosterone synthesis and spermatogenesis in mice","volume":"88","author":"Jia","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbrc.2017.03.098_bib32","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s10815-014-0184-5","article-title":"Effect of beta-carotene on titanium oxide nanoparticles-induced testicular toxicity in mice","volume":"31","author":"Orazizadeh","year":"2014","journal-title":"J.\u00a0Assist. Reprod. Genet."},{"issue":"43","key":"10.1016\/j.bbrc.2017.03.098_bib33","doi-asserted-by":"crossref","first-page":"13608","DOI":"10.1021\/jp712087m","article-title":"Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species","volume":"112","author":"Carlson","year":"2008","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.bbrc.2017.03.098_bib34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mrgentox.2011.10.011","article-title":"Genotoxicity of inhaled nanosized TiO2 in mice","volume":"745","author":"Lindberg","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bbrc.2017.03.098_bib35","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3109\/17435390.2011.587903","article-title":"Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in A549 cells","volume":"6","author":"Jugan","year":"2012","journal-title":"Nanotoxicology"},{"issue":"5","key":"10.1016\/j.bbrc.2017.03.098_bib36","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1262\/jrd.2011-010","article-title":"Accumulated HSV1-TK proteins interfere with spermatogenesis through a disruption of the integrity of Sertoli-germ cell junctions","volume":"58","author":"Cai","year":"2012","journal-title":"J.\u00a0Reprod. Dev."},{"issue":"4","key":"10.1016\/j.bbrc.2017.03.098_bib37","first-page":"1367","article-title":"Influence of nano-silver on secondary follicles of ovary via intraperitoneal injection in rats","volume":"2","author":"Ghorbanzadeh","year":"2012","journal-title":"Eur. J. Exper. Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17305648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17305648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T10:25:44Z","timestamp":1535970344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X17305648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0006291X17305648"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.03.098","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reproductive toxicity provoked by titanium dioxide nanoparticles and the ameliorative role of Tiron in adult male rats","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.03.098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}