{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T23:31:17Z","timestamp":1774135877037,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Educational Commission of Shanghai","award":["1015508802"],"award-info":[{"award-number":["1015508802"]}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Committee","doi-asserted-by":"publisher","award":["15411951700"],"award-info":[{"award-number":["15411951700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.bbrc.2017.03.120","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T06:00:23Z","timestamp":1490248823000},"page":"781-787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Disturbed tryptophan metabolism correlating to progression and metastasis of esophageal squamous cell carcinoma"],"prefix":"10.1016","volume":"486","author":[{"given":"Jing","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianfu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2017.03.120_bib1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4291\/wjgp.v5.i3.335","article-title":"Epidemiological studies of esophageal cancer in the era of genome-wide association studies","volume":"5","author":"Wang","year":"2014","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"10.1016\/j.bbrc.2017.03.120_bib2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1055\/s-2002-19852","article-title":"Diagnosis of esophagogastric tumors","volume":"34","author":"Lambert","year":"2002","journal-title":"Endoscopy"},{"key":"10.1016\/j.bbrc.2017.03.120_bib3","first-page":"3519","article-title":"Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCC","volume":"7","author":"Hu","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2017.03.120_bib4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/(SICI)1097-0215(20000515)86:4<533::AID-IJC15>3.0.CO;2-O","article-title":"Genetic alterations involving exon 3 of the beta-catenin gene do not play a role in adenocarcinomas of the esophagus","volume":"86","author":"Wijnhoven","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbrc.2017.03.120_bib5","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1021\/pr500483z","article-title":"Serum metabolomics signatures of lymph node metastasis of esophageal squamous cell carcinoma","volume":"13","author":"Jin","year":"2014","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.bbrc.2017.03.120_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","article-title":"The emerging hallmarks of cancer metabolism","volume":"23","author":"Pavlova","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2017.03.120_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jprot.2013.10.002","article-title":"Comparative metabolomics of estrogen receptor positive and estrogen receptor negative breast cancer: alterations in glutamine and beta-alanine metabolism","volume":"94","author":"Budczies","year":"2013","journal-title":"J.\u00a0Proteom."},{"key":"10.1016\/j.bbrc.2017.03.120_bib8","doi-asserted-by":"crossref","first-page":"e30181","DOI":"10.1371\/journal.pone.0030181","article-title":"Esophageal cancer metabolite biomarkers detected by LC-MS and NMR methods","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2017.03.120_bib9","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1158\/1078-0432.CCR-13-1939","article-title":"A\u00a0distinct metabolic signature of human colorectal cancer with prognostic potential","volume":"20","author":"Qiu","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2017.03.120_bib10","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1007\/s00216-013-6774-8","article-title":"Study of metabolomic profiles of human esophageal carcinoma by use of high-resolution magic-angle spinning 1H NMR spectroscopy and multivariate data analysis","volume":"405","author":"Yang","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.bbrc.2017.03.120_bib11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jprot.2015.05.013","article-title":"LC-MS-based serum metabolomic analysis reveals dysregulation of phosphatidylcholines in esophageal squamous cell carcinoma","volume":"127","author":"Mir","year":"2015","journal-title":"J.\u00a0Proteom."},{"key":"10.1016\/j.bbrc.2017.03.120_bib12","doi-asserted-by":"crossref","first-page":"e0122046","DOI":"10.1371\/journal.pone.0122046","article-title":"Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers","volume":"10","author":"Puccetti","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2017.03.120_bib13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1158\/1055-9965.EPI-13-0770","article-title":"Circulating biomarkers of tryptophan and the kynurenine pathway and lung cancer risk","volume":"23","author":"Chuang","year":"2014","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.bbrc.2017.03.120_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.trsl.2015.07.003","article-title":"Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer","volume":"167","author":"Santhanam","year":"2016","journal-title":"Transl. Res."},{"key":"10.1016\/j.bbrc.2017.03.120_bib15","first-page":"1","article-title":"Towards tyrosine metabolism in esophageal squamous cell carcinoma","volume":"20","author":"Cheng","year":"2017","journal-title":"Comb. Chem. High. T SCR"},{"key":"10.1016\/j.bbrc.2017.03.120_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.it.2012.10.001","article-title":"Indoleamine 2,3 dioxygenase and metabolic control of immune responses","volume":"34","author":"Munn","year":"2013","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbrc.2017.03.120_bib17","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1158\/0008-5472.CAN-12-0569","article-title":"Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion","volume":"72","author":"Platten","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2017.03.120_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1079\/NRR200133","article-title":"Tryptophan metabolism in alcoholism","volume":"15","author":"Badawy","year":"2002","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.bbrc.2017.03.120_bib19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/1097-0142(19880715)62:2<355::AID-CNCR2820620221>3.0.CO;2-E","article-title":"Preoperative and postoperative levels of plasma protein and amino acid in esophageal and lung cancer patients","volume":"62","author":"Naini","year":"1988","journal-title":"Cancer"},{"key":"10.1016\/j.bbrc.2017.03.120_bib20","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.bbadis.2013.03.009","article-title":"Metabolic signatures of esophageal cancer: NMR-based metabolomics and UHPLC-based focused metabolomics of blood serum","volume":"1832","author":"Zhang","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2017.03.120_bib21","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/bph.12230","article-title":"The kynurenine pathway as a therapeutic target in cognitive and neurode generative disorders","volume":"169","author":"Stone","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2017.03.120_bib22","first-page":"120","article-title":"Study of 5HT3 and HT4 receptor expression in HT29 cell line and human colon adenocarcinoma tissues","volume":"13","author":"Ataee","year":"2010","journal-title":"Arch. Iran. Med."},{"key":"10.1016\/j.bbrc.2017.03.120_bib23","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s00726-010-0752-7","article-title":"Tryptophan metabolism, from nutrition to potential therapeutic applications","volume":"41","author":"Le Floc'h","year":"2011","journal-title":"Amino acids"},{"key":"10.1016\/j.bbrc.2017.03.120_bib24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cca.2005.06.013","article-title":"Monitoring tryptophan metabolism in chronic immune activation","volume":"364","author":"Schrocksnadel","year":"2006","journal-title":"Clin. Chim. acta"},{"key":"10.1016\/j.bbrc.2017.03.120_bib25","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00262-014-1549-4","article-title":"Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer","volume":"63","author":"Prendergast","year":"2014","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bbrc.2017.03.120_bib26","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s00726-010-0787-9","article-title":"Kynurenine metabolism in health and disease","volume":"41","author":"Kolodziej","year":"2011","journal-title":"Amino acids"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17305880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17305880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T04:30:33Z","timestamp":1535949033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X17305880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0006291X17305880"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.03.120","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disturbed tryptophan metabolism correlating to progression and metastasis of esophageal squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.03.120","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}