{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:23:03Z","timestamp":1762352583342,"version":"3.41.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010845","name":"Harbin Science and Technology Bureau","doi-asserted-by":"crossref","award":["2016RAXYJ056"],"award-info":[{"award-number":["2016RAXYJ056"]}],"id":[{"id":"10.13039\/501100010845","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.bbrc.2017.04.046","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T20:47:01Z","timestamp":1492030021000},"page":"262-267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Knockdown of Nucleostemin in an ovarian cancer SKOV-3\u00a0cell line and its effects on cell malignancy"],"prefix":"10.1016","volume":"487","author":[{"given":"Jiao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingchun","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"no. 1","key":"10.1016\/j.bbrc.2017.04.046_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2017.04.046_bib2","first-page":"205","article-title":"Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells","volume":"16","author":"Han","year":"2005","journal-title":"Int. J. Mol. Med."},{"issue":"no. 1","key":"10.1016\/j.bbrc.2017.04.046_bib3","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bbrc.2013.10.032","article-title":"Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells","volume":"441","author":"Yamashita","year":"2013","journal-title":"Biochem. Biophysical Res. Commun."},{"issue":"no. 10","key":"10.1016\/j.bbrc.2017.04.046_bib4","first-page":"17634","article-title":"Nucleostemin regulates proliferation and migration of gastric cancer and correlates with its malignancy","volume":"8","author":"Wu","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"no. 1","key":"10.1016\/j.bbrc.2017.04.046_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13058-015-0551-x","article-title":"FAK activity protects Nucleostemin in facilitating breast cancer spheroid and tumor growth","volume":"17","author":"Isabelle","year":"2015","journal-title":"Breast Cancer Res."},{"issue":"no. 4","key":"10.1016\/j.bbrc.2017.04.046_bib6","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/dvdy.21027","article-title":"Rapid accumulation of Nucleostemin in nucleolus during newt regeneration","volume":"236","author":"Maki","year":"2007","journal-title":"Dev. Dyn."},{"issue":"no. 7","key":"10.1016\/j.bbrc.2017.04.046_bib7","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/IGC.0b013e31822c76e1","article-title":"Clinical significance of Nucleostemin expression and its correlation with cyclin D1 expression in malignant ovarian tumors","volume":"21","author":"Lin","year":"2011","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"no. 5","key":"10.1016\/j.bbrc.2017.04.046_bib8","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1083\/jcb.201109038","article-title":"Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1","volume":"197","author":"Hsu","year":"2012","journal-title":"J.\u00a0Cell Biol."},{"issue":"no. 23","key":"10.1016\/j.bbrc.2017.04.046_bib9","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1101\/gad.55671","article-title":"A\u00a0nucleolar mechanism controlling cell proliferation in stem cells and cancer cells","volume":"16","author":"Tsai","year":"2002","journal-title":"Genes & Dev."},{"issue":"no. 7","key":"10.1016\/j.bbrc.2017.04.046_bib10","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1091\/mbc.E07-03-0244","article-title":"Depletion of the nucleolar protein Nucleostemin causes G1 cell cycle arrest via the p53 pathway","volume":"18","author":"Ma","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2017.04.046_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/cddiscovery.2015.60","article-title":"p53 Configures the G2\/M arrest response of nucleostemin-deficient cells","volume":"1","author":"Huang","year":"2015","journal-title":"Cell death Discov."},{"key":"10.1016\/j.bbrc.2017.04.046_bib12","first-page":"529","article-title":"The effect of knocking-down nucleostemin gene expression on the in\u00a0vitro proliferation and in\u00a0vivo tumorigenesis of HeLa cells","volume":"23","author":"Sijin","year":"2004","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"issue":"no. 24","key":"10.1016\/j.bbrc.2017.04.046_bib13","doi-asserted-by":"crossref","first-page":"9279","DOI":"10.1128\/MCB.00724-06","article-title":"Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability","volume":"26","author":"Zhu","year":"2006","journal-title":"Mol. Cell. Biol."},{"issue":"no. 13","key":"10.1016\/j.bbrc.2017.04.046_bib14","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1128\/MCB.01662-07","article-title":"Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2","volume":"28","author":"Dai","year":"2008","journal-title":"Mol. Cell. Biol."},{"issue":"no. 6","key":"10.1016\/j.bbrc.2017.04.046_bib15","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1365-2184.2009.00635.x","article-title":"Differential effects of Nucleostemin suppression on cell cycle arrest and apoptosis in the bladder cancer cell lines 5637 and SW1710","volume":"42","author":"Nikpour","year":"2009","journal-title":"Cell Prolif."},{"issue":"no. 22","key":"10.1016\/j.bbrc.2017.04.046_bib16","doi-asserted-by":"crossref","first-page":"9444","DOI":"10.1158\/0008-5472.CAN-10-2159","article-title":"Tumor-initiating function of nucleostemin-enriched mammary tumor cells","volume":"70","author":"Lin","year":"2010","journal-title":"Cancer Res."},{"issue":"no. 24","key":"10.1016\/j.bbrc.2017.04.046_bib17","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1242\/jcs.037952","article-title":"Nucleoplasmic mobilization of nucleostemin stabilizes MDM2 and promotes G2-M progression and cell survival","volume":"121","author":"Meng","year":"2008","journal-title":"J.\u00a0Cell Sci."},{"issue":"no. 8","key":"10.1016\/j.bbrc.2017.04.046_bib18","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1074\/jbc.M804594200","article-title":"Critical role of nucleostemin in pre-rRNA processing","volume":"284","author":"Romanova","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"issue":"no. 10","key":"10.1016\/j.bbrc.2017.04.046_bib19","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1242\/jcs.143842","article-title":"Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively","volume":"127","author":"Tao","year":"2014","journal-title":"J.\u00a0Cell Sci."},{"issue":"no. 12","key":"10.1016\/j.bbrc.2017.04.046_bib20","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1038\/bjc.2014.539","article-title":"Overexpression of nucleostemin contributes to an advanced malignant phenotype and a poor prognosis in oral squamous cell carcinoma","volume":"111","author":"Yoshida","year":"2014","journal-title":"Br. J. Cancer"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1730712X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1730712X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T22:10:07Z","timestamp":1750198207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X1730712X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0006291X1730712X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.04.046","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Knockdown of Nucleostemin in an ovarian cancer SKOV-3\u00a0cell line and its effects on cell malignancy","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.04.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}