{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T09:45:05Z","timestamp":1782726305241,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["26461585"],"award-info":[{"award-number":["26461585"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.bbrc.2017.05.172","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T18:04:27Z","timestamp":1496253867000},"page":"466-471","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells"],"prefix":"10.1016","volume":"489","author":[{"given":"Nobuko","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Yashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohito","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Namba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Nosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousuke","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneo","family":"Morishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Tsukahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4039-238X","authenticated-orcid":false,"given":"Masao","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2017.05.172_bib1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0891-5849(96)00131-1","article-title":"Oxidative stress during viral infection: a review","volume":"21","author":"Schwarz","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2017.05.172_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1359-6101(00)00026-5","article-title":"Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression","volume":"12","author":"Julkunen","year":"2001","journal-title":"Cytokine & Growth Factor Rev."},{"key":"10.1016\/j.bbrc.2017.05.172_bib3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nature08699","article-title":"Human host factors required for influenza virus replication","volume":"463","author":"Konig","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2017.05.172_bib4","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/ped.12139","article-title":"Pathogenic mechanisms of influenza A(H1N1)pdm09 infection elucidated on gene expression profiling","volume":"55","author":"Yamashita","year":"2013","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.bbrc.2017.05.172_bib5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1074-7613(00)80496-3","article-title":"Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing","volume":"5","author":"Aurrand-Lions","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2017.05.172_bib6","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.bbrc.2011.11.099","article-title":"Diverse biological activities of the vascular non-inflammatory molecules \u2013 the Vanin pantetheinases","volume":"417","author":"Kaskow","year":"2012","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"10.1016\/j.bbrc.2017.05.172_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0014-5793(00)02110-4","article-title":"Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice","volume":"483","author":"Pitari","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2017.05.172_bib8","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1038\/jid.2009.67","article-title":"Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines","volume":"129","author":"Jansen","year":"2009","journal-title":"J.\u00a0Invest. Dermatol"},{"key":"10.1016\/j.bbrc.2017.05.172_bib9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1203\/00006450-198107000-00018","article-title":"Pantetheinase activity and cysteamine content in cystinotic and normal fibroblasts and leukocytes","volume":"15","author":"Orloff","year":"1981","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbrc.2017.05.172_bib10","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1172\/JCI112152","article-title":"Metabolism of pantethine in cystinosis","volume":"76","author":"Wittwer","year":"1985","journal-title":"J.\u00a0Clin. Investigation"},{"key":"10.1016\/j.bbrc.2017.05.172_bib11","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jaci.2015.01.045","article-title":"Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response","volume":"136","author":"Xiao","year":"2015","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.bbrc.2017.05.172_bib12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/jn\/72.3.325","article-title":"Effects of pantothenic acid, pyridoxine and thiamine deficiencies upon antibody formation to influenza virus PR-8 in rats","volume":"72","author":"Axelrod","year":"1960","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.bbrc.2017.05.172_bib13","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.4049\/jimmunol.158.5.2363","article-title":"Regulation of IFN-alpha\/beta, MxA, 2',5'-oligoadenylate synthetase, and HLA gene expression in influenza A-infected human lung epithelial cells","volume":"158","author":"Ronni","year":"1997","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2017.05.172_bib14","doi-asserted-by":"crossref","first-page":"L270","DOI":"10.1152\/ajplung.00011.2014","article-title":"Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1","volume":"308","author":"Yeganeh","year":"2015","journal-title":"Am. J. Physiology-Lung Cell. Mol. Physiology"},{"key":"10.1016\/j.bbrc.2017.05.172_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/CCM.0b013e3182676352","article-title":"Redox-active protein thioredoxin-1 administration ameliorates influenza A virus (H1N1)-induced acute lung injury in mice","volume":"41","author":"Yashiro","year":"2013","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbrc.2017.05.172_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s13054-015-0983-9","article-title":"Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice","volume":"19","author":"Nosaka","year":"2015","journal-title":"Crit. Care"},{"key":"10.1016\/j.bbrc.2017.05.172_bib17","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ab.2009.12.010","article-title":"A\u00a0fluorescent assay suitable for inhibitor screening and vanin tissue quantification","volume":"399","author":"Ruan","year":"2010","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbrc.2017.05.172_bib18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.brainres.2007.05.007","article-title":"Cellular thiol pools are responsible for sequestration of cytotoxic reactive aldehydes: central role of free cysteine and cysteamine","volume":"1158","author":"Wood","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2017.05.172_bib19","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.pnpbp.2010.11.023","article-title":"Potential of cystamine and cysteamine in the treatment of neurodegenerative diseases","volume":"35","author":"Gibrat","year":"2011","journal-title":"Prog. Neuro-Psychopharmacology Biol. Psychiatry"},{"key":"10.1016\/j.bbrc.2017.05.172_bib20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1089\/aid.1995.11.451","article-title":"Cystamine inhibits HIV type 1 replication in cells of monocyte\/macrophage and T cell lineages","volume":"11","author":"Ho","year":"1995","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.bbrc.2017.05.172_bib21","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/infdis\/174.1.214","article-title":"In\u00a0vitro inhibition of the replication of human immunodeficiency virus type 1 by beta-mercaptoethylamine (cysteamine)","volume":"174","author":"Bergamini","year":"1996","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.bbrc.2017.05.172_bib22","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1074\/jbc.M205812200","article-title":"Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders","volume":"278","author":"Lesort","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.05.172_bib23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1471-4159.2004.02726.x","article-title":"Cystamine increases l-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation","volume":"91","author":"Fox","year":"2004","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2017.05.172_bib24","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/S0891-5849(03)00023-6","article-title":"Inhibition of influenza infection by glutathione","volume":"34","author":"Cai","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2017.05.172_bib25","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1042\/BST20140092","article-title":"Role of the Vnn1 pantetheinase in tissue tolerance to stress","volume":"42","author":"Naquet","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbrc.2017.05.172_bib26","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1172\/JCI200419557","article-title":"Vanin-1(-\/-) mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher glutathione stores","volume":"113","author":"Martin","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2017.05.172_bib27","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1084\/jem.20061640","article-title":"Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity","volume":"203","author":"Berruyer","year":"2006","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2017.05.172_bib28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/eji.200636054","article-title":"Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection","volume":"37","author":"Meghari","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbrc.2017.05.172_bib29","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1172\/JCI1355","article-title":"Local and systemic cytokine responses during experimental human influenza A virus infection - relation to symptom formation and host defense","volume":"101","author":"Hayden","year":"1998","journal-title":"J.\u00a0Clin. Investigation"},{"key":"10.1016\/j.bbrc.2017.05.172_bib30","doi-asserted-by":"crossref","DOI":"10.1186\/cc8208","article-title":"Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza","volume":"13","author":"Bermejo-Martin","year":"2009","journal-title":"Crit. Care"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17310811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17310811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T21:53:10Z","timestamp":1750283590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X17310811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0006291X17310811"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.05.172","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.05.172","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}