{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:45:16Z","timestamp":1785206716948,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Novartis Pharma AG"},{"name":"BONFOR program, Medical Faculty, University of Bonn","award":["O-109.0052"],"award-info":[{"award-number":["O-109.0052"]}]},{"DOI":"10.13039\/501100005971","name":"German Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["SFB TRR57 P18"],"award-info":[{"award-number":["SFB TRR57 P18"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Novartis Pharma AG"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.bbrc.2017.06.091","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T01:02:31Z","timestamp":1497920551000},"page":"643-649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties"],"prefix":"10.1016","volume":"490","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-403X","authenticated-orcid":false,"given":"Thomas","family":"Beiert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"Tiyerili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Knappe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Effelsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Linhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"St\u00f6ckigt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Schierwagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonel","family":"Trebicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan W.","family":"Schrickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 P.","family":"Andri\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2017.06.091_bib1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"385","year":"2015","journal-title":"Lancet (London, Engl."},{"key":"10.1016\/j.bbrc.2017.06.091_bib2","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1093\/eurheartj\/ehn579","article-title":"Atrial fibrillation in acute myocardial infarction: a systematic review of the incidence, clinical features and prognostic implications","volume":"30","author":"Schmitt","year":"2009","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbrc.2017.06.091_bib3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s12471-015-0710-9","article-title":"Myocardial infarction, atrial fibrillation and mortality: timing is everything","volume":"23","author":"van den Berg","year":"2015","journal-title":"Neth Heart J."},{"key":"10.1016\/j.bbrc.2017.06.091_bib4","doi-asserted-by":"crossref","first-page":"e000382","DOI":"10.1161\/JAHA.113.000382","article-title":"New-onset atrial fibrillation is associated with cardiovascular events leading to death in a first time myocardial infarction population of 89 703 patients with long-term follow-up: a nationwide study","volume":"3","author":"Bang","year":"2013","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.bbrc.2017.06.091_bib5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s11886-012-0289-3","article-title":"Atrial fibrillation and mortality in patients with acute myocardial infarction: a systematic overview and meta-analysis","volume":"14","author":"Angeli","year":"2012","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.bbrc.2017.06.091_bib6","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1161\/CIRCULATIONAHA.110.986661","article-title":"Mortality associated with atrial fibrillation in patients with myocardial infarction: a systematic review and meta-analysis","volume":"123","author":"Jabre","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2017.06.091_bib7","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1161\/CIRCULATIONAHA.110.990192","article-title":"Atrial fibrillation and death after myocardial infarction: a community study","volume":"123","author":"Jabre","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2017.06.091_bib8","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.amjcard.2016.01.012","article-title":"Relation of atrial fibrillation in acute myocardial infarction to in-hospital complications and early hospital readmission","volume":"117","author":"Kundu","year":"2016","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.bbrc.2017.06.091_bib9","first-page":"48","article-title":"Cardiovascular effects of relaxin: from basic science to clinical therapy, Nature reviews","volume":"7","author":"Du","year":"2010","journal-title":"Cardiology"},{"key":"10.1016\/j.bbrc.2017.06.091_bib10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s40256-014-0069-0","article-title":"Serelaxin: a novel therapy for acute heart failure with a range of hemodynamic and non-hemodynamic actions","volume":"14","author":"D\u00edez","year":"2014","journal-title":"Am. J. Cardiovasc. Drugs Drugs, Devices, Other Interventions"},{"key":"10.1016\/j.bbrc.2017.06.091_bib11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11897-010-0010-z","article-title":"Relaxin: review of biology and potential role in treating heart failure","volume":"7","author":"Teichman","year":"2010","journal-title":"Curr. Heart Fail. Rep."},{"key":"10.1016\/j.bbrc.2017.06.091_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1152\/physrev.00001.2012","article-title":"Relaxin family peptides and their receptors","volume":"93","author":"Bathgate","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2017.06.091_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2010.02.003","article-title":"Membrane receptors: structure and function of the relaxin family peptide receptors","volume":"320","author":"Kong","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbrc.2017.06.091_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0140-6736(12)61855-8","article-title":"Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial","volume":"381","author":"Teerlink","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2017.06.091_bib15","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.jacc.2014.05.071","article-title":"Effect of serelaxin on mode of death in acute heart failure","volume":"64","author":"Felker","year":"2014","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2017.06.091_bib16","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1210\/en.2008-0250","article-title":"Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy","volume":"149","author":"Samuel","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2017.06.091_bib17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/HYPERTENSIONAHA.114.03594","article-title":"Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease","volume":"64","author":"Samuel","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2017.06.091_bib18","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1210\/en.2004-0209","article-title":"Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in\u00a0vivo","volume":"145","author":"Samuel","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2017.06.091_bib19","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/labinvest.2010.198","article-title":"Relaxin remodels fibrotic healing following myocardial infarction","volume":"91","author":"Samuel","year":"2011","journal-title":"Lab. Investigation; a J. Tech. Methods Pathol."},{"key":"10.1016\/j.bbrc.2017.06.091_bib20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.phrs.2007.11.001","article-title":"Relaxin induces mast cell inhibition and reduces ventricular arrhythmias in a swine model of acute myocardial infarction","volume":"57","author":"Nistri","year":"2008","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2017.06.091_bib21","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/01.HYP.0000171930.00697.2f","article-title":"Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats","volume":"46","author":"Lekgabe","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2017.06.091_bib22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1749-6632.2008.03780.x","article-title":"Reversal of cardiac fibrosis and related dysfunction by relaxin","volume":"1160","author":"Du","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbrc.2017.06.091_bib23","first-page":"1367","article-title":"Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart","volume":"152","author":"Bani","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2017.06.091_bib24","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06321","article-title":"Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia","volume":"450","author":"Roell","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2017.06.091_bib25","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/00007890-200202150-00022","article-title":"Cellular cardiomyoplasty in a transgenic mouse model","volume":"73","author":"Roell","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.bbrc.2017.06.091_bib26","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1084\/jem.20061469","article-title":"Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium","volume":"203","author":"Kolossov","year":"2006","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2017.06.091_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.yjmcc.2013.09.008","article-title":"The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice","volume":"65","author":"L\u00fcbkemeier","year":"2013","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2017.06.091_bib28","doi-asserted-by":"crossref","first-page":"e49203","DOI":"10.1371\/journal.pone.0049203","article-title":"Total beta-adrenoceptor knockout slows conduction and reduces inducible arrhythmias in the mouse heart","volume":"7","author":"St\u00f6ckigt","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2017.06.091_bib29","doi-asserted-by":"crossref","first-page":"188","DOI":"10.5114\/aoms.2015.54146","article-title":"Deficiency of cyclase-associated protein 2 promotes arrhythmias associated with connexin43 maldistribution and fibrosis","volume":"12","author":"St\u00f6ckigt","year":"2016","journal-title":"Archives Med. Sci. AMS"},{"key":"10.1016\/j.bbrc.2017.06.091_bib30","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1073\/pnas.0508512103","article-title":"Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node","volume":"103","author":"Kreuzberg","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2017.06.091_bib31","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.mex.2015.02.007","article-title":"Determination of collagen content within picrosirius red stained paraffin-embedded tissue sections using fluorescence microscopy","volume":"2","author":"Vogel","year":"2015","journal-title":"MethodsX"},{"key":"10.1016\/j.bbrc.2017.06.091_bib32","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.atherosclerosis.2016.06.008","article-title":"Anti-atherosclerotic effects of serelaxin in apolipoprotein E-deficient mice","volume":"251","author":"Tiyerili","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbrc.2017.06.091_bib33","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/cvr\/cvu046","article-title":"Optogenetic activation of Gq signalling modulates pacemaker activity of cardiomyocytes","volume":"102","author":"Beiert","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2017.06.091_bib34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/CIRCRESAHA.113.301646","article-title":"Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts","volume":"113","author":"Parikh","year":"2013","journal-title":"Circulation Res."},{"key":"10.1016\/j.bbrc.2017.06.091_bib35","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.hrthm.2015.12.030","article-title":"Relaxin suppresses atrial fibrillation in aged rats by reversing fibrosis and upregulating Na+ channels","volume":"13","author":"Henry","year":"2016","journal-title":"Heart Rhythm Official J. Heart Rhythm Soc."},{"key":"10.1016\/j.bbrc.2017.06.091_bib36","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1006\/jmcc.2000.1215","article-title":"CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis","volume":"32","author":"Chen","year":"2000","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2017.06.091_bib37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/eurheartj\/ehv514","article-title":"Magnetic resonance imaging of atrial fibrosis: redefining atrial fibrillation to a syndrome","volume":"38","author":"Gal","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbrc.2017.06.091_bib38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbrc.2017.06.091_bib39","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nm.2124","article-title":"Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation","volume":"16","author":"Rudolph","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2017.06.091_bib40","first-page":"1525","article-title":"Novel drug development opportunity for relaxin in acute myocardial infarction: evidences from a swine model","volume":"19","author":"Perna","year":"2005","journal-title":"FASEB J. Official Publ. Fed. Am. Soc. Exp. Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17312226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17312226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T15:51:53Z","timestamp":1535730713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X17312226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0006291X17312226"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.06.091","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.06.091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}