{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:21:10Z","timestamp":1790335270455,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.bbrc.2017.07.101","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T11:27:35Z","timestamp":1500463655000},"page":"329-336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["MiR-18a-5p inhibits endothelial\u2013mesenchymal transition and cardiac fibrosis through the Notch2 pathway"],"prefix":"10.1016","volume":"491","author":[{"given":"Huazhi","family":"Geng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2017.07.101_bib1","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.2337\/diacare.13.11.1169","article-title":"Diabetic cardiomyopathy","volume":"13","author":"Fein","year":"1990","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbrc.2017.07.101_bib2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jacc.2005.09.050","article-title":"The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy","volume":"47","author":"Asbun","year":"2006","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2017.07.101_bib3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1042\/BJ20101500","article-title":"Transforming growth factor-beta2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling","volume":"437","author":"Medici","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2017.07.101_bib4","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/sj.bjc.6604662","article-title":"The role of endothelial-to-mesenchymal transition in cancer progression","volume":"99","author":"Potenta","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbrc.2017.07.101_bib5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/01.ATV.0000060892.81529.8F","article-title":"Notch signaling in vascular development","volume":"23","author":"Iso","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2017.07.101_bib6","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1161\/01.RES.0000124300.76171.C9","article-title":"Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation","volume":"94","author":"Noseda","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2017.07.101_bib7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.scr.2016.09.005","article-title":"Notch hyper-activation drives trans-differentiation of hESC-derived endothelium","volume":"17","author":"Reichman","year":"2016","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.bbrc.2017.07.101_bib8","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1182\/blood-2005-03-1000","article-title":"Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function","volume":"107","author":"Williams","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2017.07.101_bib9","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.bcp.2010.07.010","article-title":"Inflammation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunction","volume":"80","author":"Quillard","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2017.07.101_bib10","doi-asserted-by":"crossref","first-page":"11657","DOI":"10.1074\/jbc.M312102200","article-title":"Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways","volume":"279","author":"MacKenzie","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.07.101_bib11","doi-asserted-by":"crossref","first-page":"e8244","DOI":"10.1371\/journal.pone.0008244","article-title":"Notch2 signaling sensitizes endothelial cells to apoptosis by negatively regulating the key protective molecule survivin","volume":"4","author":"Quillard","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2017.07.101_bib12","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.2147\/DDDT.S85399","article-title":"Relaxin inhibits cardiac fibrosis and endothelial\u2013mesenchymal transition via the Notch pathway","author":"Zhou","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bbrc.2017.07.101_bib13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1136\/jmedgenet-2011-100544","article-title":"NOTCH2 mutations in Alagille syndrome","volume":"49","author":"Kamath","year":"2012","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.bbrc.2017.07.101_bib14","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1161\/01.CIR.0000037221.45902.69","article-title":"Analysis of cardiovascular phenotype and genotype-phenotype correlation in individuals with a JAG1 mutation and\/or Alagille syndrome","volume":"106","author":"McElhinney","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2017.07.101_bib15","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.semcdb.2012.01.010","article-title":"Notch signaling in human development and disease","volume":"23","author":"Penton","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2017.07.101_bib16","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.placenta.2008.06.004","article-title":"The notch signalling pathway in the development of the mouse placenta","volume":"29","author":"Gasperowicz","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.bbrc.2017.07.101_bib17","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nature09267","article-title":"Mammalian microRNAs predominantly act to decrease target mRNA levels","volume":"466","author":"Guo","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2017.07.101_bib18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-biochem-060308-103103","article-title":"Regulation of mRNA translation and stability by microRNAs","volume":"79","author":"Fabian","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbrc.2017.07.101_bib19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/dmrr.1054","article-title":"miR133a regulates cardiomyocyte hypertrophy in diabetes","volume":"26","author":"Feng","year":"2010","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.bbrc.2017.07.101_bib20","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/cvr\/cvr300","article-title":"Role of microRNAs in diabetes and its cardiovascular complications","volume":"93","author":"Shantikumar","year":"2012","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.bbrc.2017.07.101_bib21","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/ejhf.332","article-title":"Signature of circulating microRNAs in patients with acute heart failure","volume":"18","author":"Ovchinnikova","year":"2016","journal-title":"Eur. J. Heart Fail"},{"key":"10.1016\/j.bbrc.2017.07.101_bib22","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbrc.2017.03.056","article-title":"MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin","volume":"486","author":"Zhang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2017.07.101_bib23","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1474-9726.2011.00714.x","article-title":"MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure","volume":"10","author":"van Almen","year":"2011","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbrc.2017.07.101_bib24","doi-asserted-by":"crossref","first-page":"768","DOI":"10.2337\/db15-1033","article-title":"miR-200b mediates endothelial-to-mesenchymal transition in diabetic cardiomyopathy","volume":"65","author":"Feng","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2017.07.101_bib25","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/CIRCRESAHA.107.151381","article-title":"Notch signaling contributes to the expression of cardiac markers in human circulating progenitor cells","volume":"101","author":"Koyanagi","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2017.07.101_bib26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","article-title":"MicroRNA targeting specificity in mammals: determinants beyond seed pairing","volume":"27","author":"Grimson","year":"2007","journal-title":"Mol. Cell"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17314523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17314523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T10:46:51Z","timestamp":1574938011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X17314523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0006291X17314523"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.07.101","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-18a-5p inhibits endothelial\u2013mesenchymal transition and cardiac fibrosis through the Notch2 pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.07.101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}