{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:53:27Z","timestamp":1790009607545,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100013223","name":"Chongqing Research Program of Basic Research and Frontier Technology","doi-asserted-by":"crossref","award":["cstc2017jcyjAX0356"],"award-info":[{"award-number":["cstc2017jcyjAX0356"]}],"id":[{"id":"10.13039\/501100013223","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703527"],"award-info":[{"award-number":["81703527"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.bbrc.2017.09.152","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T03:46:37Z","timestamp":1506656797000},"page":"1402-1409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["iRhom2 deficiency relieves TNF-\u03b1 associated hepatic dyslipidemia in long-term PM2.5-exposed mice"],"prefix":"10.1016","volume":"493","author":[{"given":"Chen-Xu","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Shuai","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Xing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yang","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Xuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2017.09.152_bib1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1289\/ehp.1307823","article-title":"Association between ambient air pollution and diabetes mellitus in Europe and North America: systematic review and meta-analysis","volume":"123","author":"Eze","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bbrc.2017.09.152_bib2","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1002\/oby.20748","article-title":"Obesity and the cardiovascular health effects of fine particulate air pollution","volume":"22","author":"Weichenthal","year":"2014","journal-title":"Obesity"},{"key":"10.1016\/j.bbrc.2017.09.152_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1289\/EHP194","article-title":"Mortality due to vegetation fire\u2013originated PM2. 5 exposure in Europe\u2014assessment for the years 2005 and 2008","volume":"125","author":"Kollanus","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bbrc.2017.09.152_bib4","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/BOR.0b013e32835d951e","article-title":"Metabolic syndrome, diabetes, and hyperuricemia","volume":"25","author":"Li","year":"2013","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.bbrc.2017.09.152_bib5","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.2337\/db14-1916","article-title":"Dietary polyphenols promote growth of the gut bacterium Akkermansia muciniphila and attenuate high-fat diet\u2013induced metabolic syndrome","volume":"64","author":"Roopchand","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2017.09.152_bib6","first-page":"4","article-title":"Elevated circulating lipasin\/betatrophin in human type 2 diabetes and obesity","author":"Fu","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2017.09.152_bib7","first-page":"199","article-title":"Exposure to concentrated ambient PM2. 5 shortens lifespan and induces inflammation-associated signaling and oxidative stress in Drosophila","volume":"156","author":"Wang","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbrc.2017.09.152_bib8","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jhep.2015.07.020","article-title":"Exposure to fine airborne particulate matters induces hepatic fibrosis in murine models","volume":"63","author":"Zheng","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2017.09.152_bib9","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jnutbio.2014.02.011","article-title":"Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome","volume":"25","author":"Jacome-Sosa","year":"2014","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.bbrc.2017.09.152_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-med-090514-013832","article-title":"Liver cancer: connections with obesity, fatty liver, and cirrhosis","volume":"67","author":"Marengo","year":"2016","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bbrc.2017.09.152_bib11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jhep.2012.08.009","article-title":"Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model","volume":"58","author":"Zheng","year":"2013","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2017.09.152_bib12","doi-asserted-by":"crossref","first-page":"S758","DOI":"10.1016\/S0016-5085(17)32630-6","article-title":"A\u00a0role of IRHOM2 in chronic intestinal inflammation in IL-10-deficient mice","volume":"152","author":"Kim","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2017.09.152_bib13","first-page":"560","article-title":"iRHOM2 takes control of rheumatoid arthritis","volume":"123","author":"Lichtenthaler","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2017.09.152_bib14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Novel pro-resolving lipid mediators in inflammation are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2017.09.152_bib15","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1021\/np4009865","article-title":"Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions","volume":"77","author":"Aursnes","year":"2014","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.bbrc.2017.09.152_bib16","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.molimm.2015.05.020","article-title":"Tobacco and e-cigarette products initiate Kupffer cell inflammatory responses","volume":"67","author":"Rubenstein","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bbrc.2017.09.152_bib17","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/hep.24400","article-title":"Hypoxia-inducible transcription factor 2\u03b1 promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis","volume":"54","author":"Qu","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2017.09.152_bib18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.freeradbiomed.2016.08.021","article-title":"Nanoceria restrains PM2. 5-induced metabolic disorder and hypothalamus inflammation by inhibition of astrocytes activation related NF-\u03baB pathway in Nrf2 deficient mice","volume":"99","author":"Xu","year":"2016","journal-title":"Free Radic. Bio. Med."},{"key":"10.1016\/j.bbrc.2017.09.152_bib19","first-page":"19027","article-title":"Study on the phenotype changes of kupffer cells in non-alcoholic fatty liver","volume":"9","author":"Li","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.bbrc.2017.09.152_bib20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1053\/j.gastro.2010.03.052","article-title":"Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1\u03b2 in mice","volume":"139","author":"Miura","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2017.09.152_bib21","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1126\/science.1124147","article-title":"Hypothalamic mTOR signaling regulates food intake","volume":"312","author":"Cota","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2017.09.152_bib22","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature02440","article-title":"AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus","volume":"428","author":"Minokoshi","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2017.09.152_bib23","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1289\/ehp.0901778","article-title":"Particulate air pollution, metabolic syndrome, and heart rate variability: the multi-ethnic study of atherosclerosis (MESA)","volume":"118","author":"Park","year":"2010","journal-title":"Environ. Health. Perspect."},{"key":"10.1016\/j.bbrc.2017.09.152_bib24","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3109\/08958371003728057","article-title":"Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction","volume":"22","author":"Quan","year":"2010","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.bbrc.2017.09.152_bib25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev-physiol-021113-170252","article-title":"A\u00a0new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis","volume":"76","author":"Kajimura","year":"2014","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbrc.2017.09.152_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrn3617","article-title":"Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity","volume":"15","author":"Xanthos","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2017.09.152_bib27","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/bph.12181","article-title":"VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair","volume":"169","author":"Waschek","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2017.09.152_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuroscience.2014.04.035","article-title":"Neuropeptide Y in the rostral ventromedial medulla reverses inflammatory and nerve injury hyperalgesia in rats via non-selective excitation of local neurons","volume":"271","author":"Cleary","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2017.09.152_bib29","doi-asserted-by":"crossref","first-page":"e110162","DOI":"10.1371\/journal.pone.0110162","article-title":"The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease","volume":"9","author":"Schuck","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2017.09.152_bib30","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3109\/15476910903241704","article-title":"Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease","volume":"6","author":"Tan","year":"2009","journal-title":"J.\u00a0Immunotoxicol."},{"key":"10.1016\/j.bbrc.2017.09.152_bib31","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ihj.2014.08.006","article-title":"Prevalence of nonalcoholic fatty liver disease (NAFLD) in patients of cardiovascular diseases and its association with hs-CRP and TNF-\u03b1","volume":"66","author":"Ajmal","year":"2014","journal-title":"Indian Heart J."},{"key":"10.1016\/j.bbrc.2017.09.152_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","article-title":"Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression","volume":"140","author":"Park","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2017.09.152_bib33","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1194\/jlr.R600021-JLR200","article-title":"The role of TNF-\u03b1 in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk","volume":"48","author":"Popa","year":"2007","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.bbrc.2017.09.152_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/479739","article-title":"Resistin regulates pituitary lipid metabolism and inflammation in\u00a0vivo and in\u00a0vitro","volume":"2013","author":"Rodriguez-Pacheco","year":"2013","journal-title":"Mediat. Inflamm."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17319332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17319332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T08:44:44Z","timestamp":1589791484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X17319332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0006291X17319332"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.09.152","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"iRhom2 deficiency relieves TNF-\u03b1 associated hepatic dyslipidemia in long-term PM2.5-exposed mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.09.152","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}