{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:05:44Z","timestamp":1762459544966,"version":"build-2065373602"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.bbrc.2017.10.169","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:46:57Z","timestamp":1509497217000},"page":"145-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biophysical characterization of the basic cluster in the transcription repression domain of human MeCP2 with AT-rich DNA"],"prefix":"10.1016","volume":"495","author":[{"given":"Ameeq Ul","family":"Mushtaq","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yejin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunha","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Kyu","family":"Bang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunmi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngjoo","family":"Byun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Joon","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4764-5127","authenticated-orcid":false,"given":"Young Ho","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2017.10.169_bib1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1042\/BST0360575","article-title":"The methyl-CpG-binding protein MeCP2 and neurological disease","volume":"36","author":"Bird","year":"2008","journal-title":"Biochem. Soc. T"},{"key":"10.1016\/j.bbrc.2017.10.169_bib2","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1093\/nar\/20.19.5085","article-title":"Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA","volume":"20","author":"Meehan","year":"1992","journal-title":"Nucleic acids Res."},{"key":"10.1016\/j.bbrc.2017.10.169_bib3","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(92)90610-O","article-title":"Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA","volume":"69","author":"Lewis","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2017.10.169_bib4","first-page":"261","article-title":"Rett syndrome: a complex disorder with simple roots, Nature reviews","volume":"16","author":"Lyst","year":"2015","journal-title":"Genetics"},{"key":"10.1016\/j.bbrc.2017.10.169_bib5","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02676","article-title":"Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice","volume":"3","author":"Heckman","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.bbrc.2017.10.169_bib6","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/iub.386","article-title":"Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin","volume":"62","author":"Hansen","year":"2010","journal-title":"IUBMB life"},{"key":"10.1016\/j.bbrc.2017.10.169_bib7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2017.10.169_bib8","doi-asserted-by":"crossref","first-page":"32181","DOI":"10.1074\/jbc.M305308200","article-title":"Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation","volume":"278","author":"Georgel","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.10.169_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng1491","article-title":"Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome","volume":"37","author":"Horike","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2017.10.169_bib10","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1093\/nar\/gkr005","article-title":"Biophysical analysis and small-angle X-ray scattering-derived structures of MeCP2-nucleosome complexes","volume":"39","author":"Yang","year":"2011","journal-title":"Nucleic acids Res."},{"key":"10.1016\/j.bbrc.2017.10.169_bib11","doi-asserted-by":"crossref","first-page":"E3243","DOI":"10.1073\/pnas.1700731114","article-title":"Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders","volume":"114","author":"Kruusvee","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2017.10.169_bib12","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(01)00324-5","article-title":"Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA","volume":"105","author":"Ohki","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2017.10.169_bib13","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1002\/1873-3468.12328","article-title":"Sequence-specific DNA binding by AT-hook motifs in MeCP2","volume":"590","author":"Lyst","year":"2016","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2017.10.169_bib14","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/nn.3434","article-title":"Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR\/SMRT co-repressor","volume":"16","author":"Lyst","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrc.2017.10.169_bib15","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2005.07.021","article-title":"DNA binding selectivity of MeCP2 due to a requirement for A\/T sequences adjacent to methyl-CpG","volume":"19","author":"Klose","year":"2005","journal-title":"Mol. cell"},{"key":"10.1016\/j.bbrc.2017.10.169_bib16","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1021\/bi00185a040","article-title":"Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation","volume":"33","author":"Farrow","year":"1994","journal-title":"Biochemistry-Us"},{"key":"10.1016\/j.bbrc.2017.10.169_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/jmra.1994.1236","article-title":"Relaxation-rate measurements for N-15-H-1 groups with pulsed-field gradients and preservation of coherence pathways","volume":"111","author":"Dayie","year":"1994","journal-title":"J.\u00a0Magn. Reson Ser. A"},{"key":"10.1016\/j.bbrc.2017.10.169_bib18","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.cell.2013.01.038","article-title":"An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders","volume":"152","author":"Baker","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2017.10.169_bib19","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1093\/nar\/26.19.4413","article-title":"AT-hook motifs identified in a wide variety of DNA binding proteins","volume":"26","author":"Aravind","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2017.10.169_bib20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10858-009-9333-z","article-title":"TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts","volume":"44","author":"Shen","year":"2009","journal-title":"J.\u00a0Biomol. Nmr"},{"key":"10.1016\/j.bbrc.2017.10.169_bib21","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1021\/ja026939x","article-title":"HADDOCK: a protein-protein docking approach based on biochemical or biophysical information","volume":"125","author":"Dominguez","year":"2003","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.bbrc.2017.10.169_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrg3897","article-title":"Rett syndrome: a complex disorder with simple roots","volume":"16","author":"Lyst","year":"2015","journal-title":"Nat. Rev. Genet."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17321575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17321575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:31:42Z","timestamp":1762093902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X17321575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0006291X17321575"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.10.169","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biophysical characterization of the basic cluster in the transcription repression domain of human MeCP2 with AT-rich DNA","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.10.169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}