{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:06:46Z","timestamp":1790215606685,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"am","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE-19917"],"award-info":[{"award-number":["DE-19917"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE-03420"],"award-info":[{"award-number":["DE-03420"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE-18499"],"award-info":[{"award-number":["DE-18499"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG-053615"],"award-info":[{"award-number":["AG-053615"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE- 007327"],"award-info":[{"award-number":["DE- 007327"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.bbrc.2017.12.137","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T21:37:20Z","timestamp":1514065040000},"page":"2383-2389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis-induced inflammation in\u00a0vitro"],"prefix":"10.1016","volume":"495","author":[{"given":"Mariane Maffei","family":"Azuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Balani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Boisvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Egashira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuguno","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Hasturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Movila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2017.12.137_bib1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/prd.12006","article-title":"Learned and unlearned concepts in periodontal diagnostics: a 50-year perspective","volume":"62","author":"Armitage","year":"2013","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.bbrc.2017.12.137_bib2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00223-015-0097-z","article-title":"Palmitic acid reduces circulating bone formation markers in obese animals and impairs osteoblast activity via C16-Ceramide accumulation","volume":"98","author":"Alsahli","year":"2016","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbrc.2017.12.137_bib3","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1128\/JB.183.12.3770-3783.2001","article-title":"Bacterial diversity in human subgingival plaque","volume":"183","author":"Paster","year":"2001","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.bbrc.2017.12.137_bib4","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0757.2005.00113.x","article-title":"Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the \"red complex\", a prototype polybacterial pathogenic consortium in periodontitis","volume":"38","author":"Holt","year":"2005","journal-title":"Periodontol"},{"key":"10.1016\/j.bbrc.2017.12.137_bib5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1399-302X.2006.00264.x","article-title":"Porphyromonas gingivalis lipids and diseased dental tissues","volume":"21","author":"Nichols","year":"2006","journal-title":"Oral Microbiol. Immunol."},{"key":"10.1016\/j.bbrc.2017.12.137_bib6","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.bbalip.2017.01.008","article-title":"Phosphoglycerol dihydroceramide, a distinctive ceramide produced by Porphyromonas gingivalis, promotes RANKL-induced osteoclastogenesis by acting on non-muscle myosin II-A (Myh9), an osteoclast cell fusion regulatory factor","volume":"1862","author":"Kanzaki","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2017.12.137_bib7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2613.2000.00164.x","article-title":"Osteoclasts and giant cells: macrophage-macrophage fusion mechanism","volume":"81","author":"Vignery","year":"2000","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.bbrc.2017.12.137_bib8","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1006\/bbrc.2000.3370","article-title":"Neutral\/alkaline and acid ceramidase activities are actively released by murine endothelial cells","volume":"275","author":"Romiti","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2017.12.137_bib9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.cmet.2015.06.007","article-title":"Targeted induction of ceramide degradation leads to improved systemic metabolism and reduced hepatic steatosis","volume":"22","author":"Xia","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.bbrc.2017.12.137_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1546-0096-5-15","article-title":"Farber disease: clinical presentation, pathogenesis and a new approach to treatment","volume":"5","author":"Ehlert","year":"2007","journal-title":"Pediatr Rheumatol Online J"},{"key":"10.1016\/j.bbrc.2017.12.137_bib11","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1128\/iai.61.5.2260-2265.1993","article-title":"Interactions of Porphyromonas gingivalis with epithelial cells","volume":"61","author":"Duncan","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbrc.2017.12.137_bib12","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1902\/jop.2008.080183","article-title":"Cytokines that promote periodontal tissue destruction","volume":"79","author":"Graves","year":"2008","journal-title":"J.\u00a0Periodontol."},{"key":"10.1016\/j.bbrc.2017.12.137_bib13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/10454411980090030101","article-title":"Cytokine expression in periodontal health and disease","volume":"9","author":"Okada","year":"1998","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.bbrc.2017.12.137_bib14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1902\/jop.2004.75.3.370","article-title":"Human gingival epithelial cells produce chemotactic factors interleukin-8 and monocyte chemoattractant protein-1 after stimulation with Porphyromonas gingivalis via toll-like receptor 2","volume":"75","author":"Kusumoto","year":"2004","journal-title":"J.\u00a0Periodontol."},{"key":"10.1016\/j.bbrc.2017.12.137_bib15","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1194\/jlr.M600001-JLR200","article-title":"Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis","volume":"47","author":"Houben","year":"2006","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.bbrc.2017.12.137_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/000163500429190","article-title":"Genetic diversity of Porphyromonas gingivalis and its possible importance to pathogenicity","volume":"58","author":"Ozmeric","year":"2000","journal-title":"Acta Odontol. Scand."},{"key":"10.1016\/j.bbrc.2017.12.137_bib17","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.bbadis.2016.05.001","article-title":"Acid ceramidase and the treatment of ceramide diseases: the expanding role of enzyme replacement therapy","volume":"1862","author":"Schuchman","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2017.12.137_bib18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.mad.2006.01.003","article-title":"Shift in sphingolipid metabolism leads to an accumulation of ceramide in senescence","volume":"127","author":"Venable","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bbrc.2017.12.137_bib19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/oxfordjournals.jbchem.a022344","article-title":"Increases in ceramide levels in normal human mesangial cells subjected to different cellular stresses result from changes in distinct enzyme activities and can influence cellular responses to other stimuli","volume":"125","author":"Sweeney","year":"1999","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.bbrc.2017.12.137_bib20","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1074\/jbc.M115.666909","article-title":"Acid Ceramidase in Melanoma: expression, localization, and effects of pharmacological inhibition","volume":"291","author":"Realini","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.12.137_bib21","doi-asserted-by":"crossref","first-page":"44573","DOI":"10.1038\/srep44573","article-title":"Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2017.12.137_bib22","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.1128\/MCB.00378-12","article-title":"Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor","volume":"32","author":"Lucki","year":"2012","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2017.12.137_bib23","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1096\/fj.06-7016com","article-title":"Acid ceramidase is a novel factor required for early embryo survival","volume":"21","author":"Eliyahu","year":"2007","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2017.12.137_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.36","article-title":"Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system","volume":"7","author":"Wang","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2017.12.137_bib25","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1182\/blood.V100.9.3383","article-title":"Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis","volume":"100","author":"Coakley","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2017.12.137_bib26","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1515\/hsz-2014-0285","article-title":"Ceramide and sphingosine in pulmonary infections","volume":"396","author":"Seitz","year":"2015","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbrc.2017.12.137_bib27","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.15252\/emmm.201404075","article-title":"Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa","volume":"6","author":"Pewzner-Jung","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbrc.2017.12.137_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1471-2180-9-107","article-title":"Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism","volume":"9","author":"Stathopoulou","year":"2009","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.bbrc.2017.12.137_bib29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1574-6968.2001.tb10706.x","article-title":"Inhibition of epithelial cell apoptosis by Porphyromonas gingivalis","volume":"200","author":"Nakhjiri","year":"2001","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.bbrc.2017.12.137_bib30","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1128\/IAI.00461-16","article-title":"Proinflammatory M1 macrophages inhibit RANKL-induced osteoclastogenesis","volume":"84","author":"Yamaguchi","year":"2016","journal-title":"Infect. Immun."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17325378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X17325378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:21:42Z","timestamp":1757762502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X17325378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0006291X17325378"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.12.137","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis-induced inflammation in\u00a0vitro","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.12.137","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}