{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:40:27Z","timestamp":1778319627735,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402462"],"award-info":[{"award-number":["81402462"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.bbrc.2017.12.164","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T21:40:43Z","timestamp":1514583643000},"page":"58-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Urine volatile organic compounds as biomarkers for minimal change type nephrotic syndrome"],"prefix":"10.1016","volume":"496","author":[{"given":"Desheng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Pi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongshuang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changsong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enyou","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2017.12.164_bib1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(03)14184-0","article-title":"Nephrotic syndrome in childhood","volume":"362","author":"Eddy","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2017.12.164_bib2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1053\/ajkd.2002.31400","article-title":"Steroid responsiveness and frequency of relapse in adult-onset minimal change nephrotic syndrome","volume":"39","author":"Nakayama","year":"2002","journal-title":"Am. J. Kidney Dis. Offic.J. Natl. Kidney Found."},{"key":"10.1016\/j.bbrc.2017.12.164_bib3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1681\/ASN.V85769","article-title":"Prognostic significance of the early course of minimal change nephrotic syndrome: report of the international study of kidney disease in children","volume":"8","author":"Tarshish","year":"1997","journal-title":"J.\u00a0Am. Soc. Nephrol. : JASN"},{"key":"10.1016\/j.bbrc.2017.12.164_bib4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ki.1978.23","article-title":"Prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. A report of the international study of kidney disease in children","volume":"13","author":"Nephrotic syndrome in children","year":"1978","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2017.12.164_bib5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00281-007-0094-z","article-title":"Minimal change nephropathy and focal segmental glomerulosclerosis","volume":"29","author":"Mathieson","year":"2007","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.bbrc.2017.12.164_bib6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/j.ajkd.2012.02.330","article-title":"Bleeding complications of native kidney biopsy: a systematic review and meta-analysis","volume":"60","author":"Corapi","year":"2012","journal-title":"Am. J. Kidney Dis. Offic. J. Natl. Kidney Found."},{"key":"10.1016\/j.bbrc.2017.12.164_bib7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s10157-004-0326-7","article-title":"Risk factors for bleeding complications in percutaneous renal biopsy","volume":"9","author":"Eiro","year":"2005","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.bbrc.2017.12.164_bib8","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.ajkd.2003.08.001","article-title":"Approach to renal biopsy","volume":"42","author":"Fogo","year":"2003","journal-title":"Am. J. Kidney Dis. Offic. J. Natl. Kidney Found."},{"key":"10.1016\/j.bbrc.2017.12.164_bib9","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1002\/(SICI)1097-0231(19991115)13:21<2160::AID-RCM768>3.0.CO;2-D","article-title":"Electrospray ionization mass spectrometry of 5-methyl-2'-deoxycytidine and its determination in urine by liquid chromatography\/electrospray ionization tandem mass spectrometry","volume":"13","author":"Zambonin","year":"1999","journal-title":"Rapid Commun. Mass Spectrom. : RCM"},{"key":"10.1016\/j.bbrc.2017.12.164_bib10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jchromb.2004.09.032","article-title":"Diagnosis of liver cancer using hplc-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases","volume":"813","author":"Yang","year":"2004","journal-title":"J.\u00a0Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bbrc.2017.12.164_bib11","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.3748\/wjg.v11.i25.3871","article-title":"Urinary nucleosides as biological markers for patients with colorectal cancer","volume":"11","author":"Zheng","year":"2005","journal-title":"World J. Gastroenterol. : WjG"},{"key":"10.1016\/j.bbrc.2017.12.164_bib12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.clinbiochem.2004.09.021","article-title":"Clinical significance and prognostic value of urinary nucleosides in breast cancer patients","volume":"38","author":"Zheng","year":"2005","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.bbrc.2017.12.164_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087731","article-title":"Urinary peptide profiling to differentiate between minimal change disease and focal segmental glomerulosclerosis","volume":"9","author":"Perez","year":"2014","journal-title":"PLos One"},{"key":"10.1016\/j.bbrc.2017.12.164_bib14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.aca.2009.06.033","article-title":"Metabolomic profiling of human urine in hepatocellular carcinoma patients using gas chromatography\/mass spectrometry","volume":"648","author":"Wu","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bbrc.2017.12.164_bib15","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1248\/bpb.35.639","article-title":"Metabolomics study on the biochemical profiles of odor elements in urine of human with bladder cancer","volume":"35","author":"Jobu","year":"2012","journal-title":"Biol. Pharmaceut. Bull."},{"key":"10.1016\/j.bbrc.2017.12.164_bib16","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1038\/bjc.2011.437","article-title":"Investigation of urinary volatile organic metabolites as potential cancer biomarkers by solid-phase microextraction in combination with gas chromatography-mass spectrometry","volume":"105","author":"Silva","year":"2011","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.bbrc.2017.12.164_bib17","doi-asserted-by":"crossref","first-page":"037022","DOI":"10.1088\/1752-7155\/2\/3\/037022","article-title":"A\u00a0comparative study of the analysis of human urine headspace using gas chromatography-mass spectrometry","volume":"2","author":"Smith","year":"2008","journal-title":"J.\u00a0Breath Res."},{"key":"10.1016\/j.bbrc.2017.12.164_bib18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0378-4347(00)00554-5","article-title":"Headspace solid-phase microextraction profiling of volatile compounds in urine: application to metabolic investigations","volume":"753","author":"Mills","year":"2001","journal-title":"J.\u00a0Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.bbrc.2017.12.164_bib19","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jchromb.2005.05.028","article-title":"Preliminary investigation of using volatile organic compounds from human expired air, blood and urine for locating entrapped people in earthquakes","volume":"822","author":"Statheropoulos","year":"2005","journal-title":"J.\u00a0Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bbrc.2017.12.164_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0021-9673(99)00017-5","article-title":"Analysis of volatile organic compounds in human urine by headspace gas chromatography-mass spectrometry with a multipurpose sampler","volume":"847","author":"Wahl","year":"1999","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.bbrc.2017.12.164_bib21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF00297111","article-title":"Identification of the n-heptane metabolites in rat and human urine","volume":"58","author":"Perbellini","year":"1986","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbrc.2017.12.164_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108750","article-title":"Detection of colorectal cancer (crc) by urinary volatile organic compound analysis","volume":"9","author":"Arasaradnam","year":"2014","journal-title":"PLos One"},{"key":"10.1016\/j.bbrc.2017.12.164_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/carcin\/bgt352","article-title":"Urinary metabolites of a polycyclic aromatic hydrocarbon and volatile organic compounds in relation to lung cancer development in lifelong never smokers in the shanghai cohort study","volume":"35","author":"Yuan","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbrc.2017.12.164_bib24","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1271\/bbb.110760","article-title":"Urinary volatile compounds as biomarkers for lung cancer","volume":"76","author":"Hanai","year":"2012","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.bbrc.2017.12.164_bib25","doi-asserted-by":"crossref","first-page":"5526","DOI":"10.1021\/ac200265g","article-title":"Use of urine volatile organic compounds to discriminate tuberculosis patients from healthy subjects","volume":"83","author":"Banday","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbrc.2017.12.164_bib26","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000335383","article-title":"Uromodulin and alpha(1)-antitrypsin urinary peptide analysis to differentiate glomerular kidney diseases","volume":"35","author":"Navarro-Munoz","year":"2012","journal-title":"Kidney Blood Pres. Res."},{"key":"10.1016\/j.bbrc.2017.12.164_bib27","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3109\/15376516.2012.682664","article-title":"Temporal profiling of human urine vocs and its potential role under the ruins of collapsed buildings","volume":"22","author":"Mochalski","year":"2012","journal-title":"Toxicol. Mech. Meth."},{"key":"10.1016\/j.bbrc.2017.12.164_bib28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1515\/CCLM.2001.146","article-title":"Identifying bacteria in human urine: current practice and the potential for rapid, near-patient diagnosis by sensing volatile organic compounds","volume":"39","author":"Guernion","year":"2001","journal-title":"Clin. Chem. Lab. Med. : CCLM \/ FESCC"},{"key":"10.1016\/j.bbrc.2017.12.164_bib29","doi-asserted-by":"crossref","first-page":"027003","DOI":"10.1088\/1752-7155\/3\/2\/027003","article-title":"Breath acetone-aspects of normal physiology related to age and gender as determined in a ptr-ms study","volume":"3","author":"Schwarz","year":"2009","journal-title":"J.\u00a0Breath Res."},{"key":"10.1016\/j.bbrc.2017.12.164_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2369-15-43","article-title":"Blood and breath profiles of volatile organic compounds in patients with end-stage renal disease","volume":"15","author":"Mochalski","year":"2014","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.bbrc.2017.12.164_bib31","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/ndt\/gfh425","article-title":"4-heptanone is a metabolite of the plasticizer di(2-ethylhexyl) phthalate (dehp) in haemodialysis patients","volume":"19","author":"Wahl","year":"2004","journal-title":"Nephrology, Dialysis, Transplantation Official Publication of the European Dialysis and Transplant Association - European Renal Association"},{"key":"10.1016\/j.bbrc.2017.12.164_bib32","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0021-9673(01)92063-1","article-title":"Volatile substances in blood serum: profile analysis and quantitative determination","volume":"142","author":"Liebich","year":"1977","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.bbrc.2017.12.164_bib33","first-page":"47","article-title":"Urine pyrrolles revisited","volume":"15","author":"Jackson","year":"2000","journal-title":"J.\u00a0Orthomol. Med."},{"key":"10.1016\/j.bbrc.2017.12.164_bib34","first-page":"96","article-title":"Urinary pyrrole in health and disease","volume":"12","author":"Jackson","year":"1997","journal-title":"J.\u00a0Orthomol. Med."},{"key":"10.1016\/j.bbrc.2017.12.164_bib35","series-title":"Fenaroli's Handbook of Flavor Ingredients","author":"GA","year":"2005"},{"key":"10.1016\/j.bbrc.2017.12.164_bib36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S1567-5688(01)80272-5","article-title":"Breath isoprene as a measure of the depression in cholesterol synthesis in intensive care patients","volume":"2","author":"Hyspler","year":"2001","journal-title":"Atherosclerosis Suppl."},{"key":"10.1016\/j.bbrc.2017.12.164_bib37","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0021-9150(99)80791-6","article-title":"Isoprene in expired air as a marker of cholesterol synthesis for the statin therapy monitoring","volume":"144","author":"Zadak","year":"1999","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbrc.2017.12.164_bib38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0024-3205(78)90416-2","article-title":"Isoprene, an endogenous constituent of human alveolar air with a diurnal pattern of excretion","volume":"22","author":"DeMaster","year":"1978","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2017.12.164_bib39","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jtbi.2010.09.028","article-title":"Physiological modeling of isoprene dynamics in exhaled breath","volume":"267","author":"King","year":"2010","journal-title":"J.\u00a0Theor. Biol."},{"key":"10.1016\/j.bbrc.2017.12.164_bib40","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/clinchem\/47.6.1053","article-title":"Analysis of volatile disease markers in blood","volume":"47","author":"Miekisch","year":"2001","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bbrc.2017.12.164_bib41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0009-3084(88)90121-1","article-title":"Small hydrocarbons formed by the peroxidation of squalene","volume":"46","author":"Stein","year":"1988","journal-title":"Chem. Phys. Lipids"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1732572X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1732572X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T11:01:03Z","timestamp":1760007663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X1732572X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0006291X1732572X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.12.164","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urine volatile organic compounds as biomarkers for minimal change type nephrotic syndrome","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2017.12.164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}