{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:51:57Z","timestamp":1790787117441,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.bbrc.2018.01.132","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T08:58:30Z","timestamp":1517389110000},"page":"880-886","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice"],"prefix":"10.1016","volume":"496","author":[{"given":"Yen-Cheng","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Ting","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7127-0046","authenticated-orcid":false,"given":"Ying-Hsien","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.01.132_bib1","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2018.01.132_bib2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrgastro.2010.97","article-title":"Evolving challenges in hepatic fibrosis","volume":"7","author":"Friedman","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2018.01.132_bib3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2018.01.132_bib4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s10495-013-0909-4","article-title":"MicroRNA-29a protects against acute liver injury in a mouse model of obstructive jaundice via inhibition of the extrinsic apoptosis pathway","volume":"19","author":"Tiao","year":"2014","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbrc.2018.01.132_bib5","article-title":"Activation of Mir-29a in activated hepatic stellate cells modulates its profibrogenic phenotype through inhibition of histone deacetylases 4","volume":"10","author":"Huang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.01.132_bib6","article-title":"Microarray study of pathway analysis expression profile associated with MicroRNA-29a with regard to murine cholestatic liver injuries","volume":"17","author":"Li","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2018.01.132_bib7","article-title":"MicroRNA-29a alleviates bile duct ligation exacerbation of hepatic fibrosis in mice through epigenetic control of methyltransferases","volume":"18","author":"Yang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2018.01.132_bib8","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3390\/ijms17030324","article-title":"Microarray study of pathway analysis expression profile associated with MicroRNA-29a with regard to murine cholestatic liver injuries","volume":"17","author":"Li","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2018.01.132_bib9","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.intimp.2007.05.016","article-title":"Toll-like receptors in inflammation, infection and cancer","volume":"7","author":"Chen","year":"2007","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2018.01.132_bib10","first-page":"196","article-title":"Gamma-glutamyl transferase in the diagnosis of biliary atresia","volume":"48","author":"Tang","year":"2007","journal-title":"Acta Paediatr Taiwan"},{"key":"10.1016\/j.bbrc.2018.01.132_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0306164","article-title":"DAMPs, PAMPs and alarmins: all we need to know about danger","volume":"81","author":"Bianchi","year":"2007","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.bbrc.2018.01.132_bib12","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1016\/j.jss.2011.05.033","article-title":"Glucocorticoid modulates high-mobility group box 1 expression and Toll-like receptor activation in obstructive jaundice","volume":"170","author":"Huang","year":"2011","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.bbrc.2018.01.132_bib13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-065X.2007.00574.x","article-title":"High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity","volume":"220","author":"Bianchi","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbrc.2018.01.132_bib14","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.11339.1","article-title":"BRD4 inhibition for the treatment of pathological organ fibrosis","volume":"6","author":"Stratton","year":"2017","journal-title":"F1000Res"},{"key":"10.1016\/j.bbrc.2018.01.132_bib15","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.3892\/etm.2015.2789","article-title":"BET protein inhibition mitigates acute myocardial infarction damage in rats via the TLR4\/TRAF6\/NF-kappaB pathway","volume":"10","author":"Sun","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbrc.2018.01.132_bib16","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1073\/pnas.82.24.8681","article-title":"Hepatic lipocytes: the principal collagen-producing cells of normal rat liver","volume":"82","author":"Friedman","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2018.01.132_bib17","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0016-5085(00)70369-6","article-title":"Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant","volume":"118","author":"Saito","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2018.01.132_bib18","first-page":"1179","article-title":"Mechanism of neutrophil accumulation in sinusoids after extrahepatic biliary obstruction","volume":"55","author":"Wakabayashi","year":"2008","journal-title":"Hepatoastroenterol."},{"key":"10.1016\/j.bbrc.2018.01.132_bib19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0168-8278(00)80272-X","article-title":"Effects of lipopolysaccharide on TNF-alpha production, hepatic NOS2 activity, and hepatic toxicity in rats with cirrhosis","volume":"33","author":"Heller","year":"2000","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2018.01.132_bib20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0016-5085(97)70105-7","article-title":"Induction of neutrophil-attracting chemokines in transforming rat hepatic stellate cells","volume":"113","author":"Sprenger","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2018.01.132_bib21","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0168-8278(02)00234-9","article-title":"Hepatic oxidative alterations in patients with extra-hepatic cholestasis. Effect of surgical drainage","volume":"37","author":"Vendemiale","year":"2002","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2018.01.132_bib22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jss.2007.05.040","article-title":"Excessive inflammation but decreased immunological response renders liver susceptible to infection in bile duct ligated mice","volume":"146","author":"Morita","year":"2008","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.bbrc.2018.01.132_bib23","first-page":"1507","article-title":"A\u00a0dual inhibitor of TNF-alpha and IL-1 mitigates liver and kidney dysfunction and improves survival in rat endotoxemia","volume":"52","author":"Takeyoshi","year":"2005","journal-title":"Hepatoastroenterol."},{"key":"10.1016\/j.bbrc.2018.01.132_bib24","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.07.099","article-title":"Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice","volume":"143","author":"Hartmann","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2018.01.132_bib25","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.febslet.2014.04.042","article-title":"Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAPK and NF-kappaB signaling pathways","volume":"588","author":"Ji","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2018.01.132_bib26","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2018.01.132_bib27","first-page":"344","article-title":"Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology","volume":"3","author":"Weiskirchen","year":"2014","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.bbrc.2018.01.132_bib28","doi-asserted-by":"crossref","first-page":"G1318","DOI":"10.1152\/ajpgi.00405.2005","article-title":"LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice","volume":"290","author":"Isayama","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbrc.2018.01.132_bib29","doi-asserted-by":"crossref","first-page":"E3993","DOI":"10.1073\/pnas.1700109114","article-title":"Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IkappaBalpha","volume":"114","author":"Bao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2018.01.132_bib30","doi-asserted-by":"crossref","first-page":"15713","DOI":"10.1073\/pnas.1522163112","article-title":"BRD4 is a novel therapeutic target for liver fibrosis","volume":"112","author":"Ding","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18301475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18301475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T13:09:00Z","timestamp":1603717740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18301475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0006291X18301475"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.01.132","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.01.132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}