{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:56:39Z","timestamp":1791644199616,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Tunisian Ministry of Higher Education and Scientific Research","award":["LR11IPT08"],"award-info":[{"award-number":["LR11IPT08"]}]},{"name":"Pasteur Institute of Tunisia","award":["LNFP\/Pro 152012"],"award-info":[{"award-number":["LNFP\/Pro 152012"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.bbrc.2018.01.133","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T13:54:00Z","timestamp":1517406840000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["RK1, the first very short peptide from Buthus occitanus tunetanus inhibits tumor cell migration, proliferation and angiogenesis"],"prefix":"10.1016","volume":"499","author":[{"given":"Oussema","family":"Khamessi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem","family":"Ben Mabrouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rym","family":"ElFessi-Magouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riadh","family":"Kharrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.01.133_bib1","doi-asserted-by":"crossref","unstructured":"World Health Organization (WHO). http:\/\/www.who.int\/cancer\/en\/, 2018 (accessed 1 January 2018).","DOI":"10.1002\/9781118924396.wbiea1496"},{"key":"10.1016\/j.bbrc.2018.01.133_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2018.01.133_bib3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/10623320600698037","article-title":"Vascular integrins in tumor angiogenesis: mediators and therapeutic targets","volume":"13","author":"Alghisi","year":"2006","journal-title":"Endothelium"},{"key":"10.1016\/j.bbrc.2018.01.133_bib4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.toxicon.2012.04.349","article-title":"Actions of the Kunitz-type serine protease inhibitor Amblyomin-X on VEGF-A- induced angiogenesis","volume":"60","author":"Drewes","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.bbrc.2018.01.133_bib5","first-page":"159","article-title":"Growth and vascularization of transplanted mouse melanomas","volume":"4","author":"Algire","year":"1948","journal-title":"AnnN. Y. Acad. Sci."},{"key":"10.1016\/j.bbrc.2018.01.133_bib6","first-page":"2109","article-title":"Proceedings: tumor angiogenesis factor","volume":"34","author":"Folkman","year":"1974","journal-title":"Cancer. Res."},{"key":"10.1016\/j.bbrc.2018.01.133_bib7","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/329671a0","article-title":"A\u00a0family of angiogenic peptides","volume":"329","author":"Folkman","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2018.01.133_bib8","first-page":"5","article-title":"In\u00a0vitro anticancer effect of venom from Cuban scorpion Rhopalurus junceus against a panel of human cancer cell lines","volume":"4","author":"D\u00edaz Garc\u00eda","year":"2013","journal-title":"J.\u00a0Venom Res."},{"key":"10.1016\/j.bbrc.2018.01.133_bib9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.toxicon.2011.01.002","article-title":"Arthropod venoms and cancer","volume":"57","author":"Heinen","year":"2011","journal-title":"Toxicon"},{"key":"10.1016\/j.bbrc.2018.01.133_bib10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/jnr.20240","article-title":"Role for calcium-activated potassium channels (BK) in growth control of human malignant glioma cells","volume":"78","author":"Weaver","year":"2004","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.bbrc.2018.01.133_bib11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000016309","article-title":"K+ channel-dependent migration of fibroblasts and human melanoma cells","volume":"9","author":"Schwab","year":"1999","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbrc.2018.01.133_bib12","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3390\/toxins7041079","article-title":"Chlorotoxin : a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion","volume":"7","author":"Dardevet","year":"2015","journal-title":"Toxins"},{"key":"10.1016\/j.bbrc.2018.01.133_bib13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.toxicon.2014.11.233","article-title":"Scorpion venom components as potential candidates for drug development","volume":"93","author":"Ortiz","year":"2015","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.bbrc.2018.01.133_bib14","first-page":"356","article-title":"Anti-cancerous applications of scorpion venom","volume":"4","author":"Mishal","year":"2013","journal-title":"Int. J. Biol. Pharmaceut. Res."},{"key":"10.1016\/j.bbrc.2018.01.133_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1371\/journal.pone.0137611","article-title":"Characterization of Kbot21 reveals novel side chain interactions of scorpion toxins inhibiting voltage-gated potassium channels","volume":"10","author":"ElFessi Magouri","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.01.133_bib16","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.peptides.2004.02.017","article-title":"Kbot1, a three disulfide bridges toxin from Buthus occitanus tunetanus venom highly active on both SK and Kv channels","volume":"25","author":"Mahjoubi Boubaker","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.bbrc.2018.01.133_bib17","first-page":"51046","article-title":"In\u00a0vitro cell migration and invasion assays","volume":"88","author":"Justus","year":"2014","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.bbrc.2018.01.133_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival:application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J.\u00a0Immunol. Meth."},{"key":"10.1016\/j.bbrc.2018.01.133_bib19","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neuroscience.2003.08.005","article-title":"Diphenhydramine-induced amnesia is mediated by Gi- protein activation","volume":"122","author":"Galeotti","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2018.01.133_bib20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.peptides.2015.05.015","article-title":"Kbot55, purified from Buthus occitanus tunetanus venom represents the first member of a novel \u03b1-KTx subfamily","volume":"80","author":"ElFessi Magouri","year":"2016","journal-title":"Peptides"},{"key":"10.1016\/j.bbrc.2018.01.133_bib21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/1535370213513991","article-title":"Scorpion venoms as a potential source of novel cancer therapeutic compounds","volume":"239","author":"Ding","year":"2014","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.bbrc.2018.01.133_bib22","first-page":"1571","article-title":"Effects of animal venoms and toxins on hallmarks of cancer","volume":"7","author":"Chaisakul","year":"2016","journal-title":"J.\u00a0Canc."},{"issue":"8","key":"10.1016\/j.bbrc.2018.01.133_bib23","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.toxicon.2005.09.006","article-title":"Overview of scorpion toxins specific for Na\u00a0+ channels and related peptides: biodiversity, structure\u2013function relationships and evolution","volume":"46","author":"De la Vega","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.bbrc.2018.01.133_bib24","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0300-9084(00)01167-6","article-title":"Peptides and genes coding for scorpion toxins that affect ion-channels","volume":"82","author":"Possani","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.bbrc.2018.01.133_bib25","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.toxicon.2010.09.008","article-title":"Apoptogenic peptides from Tityus discrepans scorpion venom acting against the SKBR3 breast cancer cell line","volume":"56","author":"D'Suze","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.bbrc.2018.01.133_bib26","first-page":"80","article-title":"Multiple cancers of the head and neck","volume":"8","author":"Heroiu Cataloiu","year":"2013","journal-title":"Maedica. (Buchar)"},{"key":"10.1016\/j.bbrc.2018.01.133_bib27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11010-010-0652-x","article-title":"Scorpion (Odontobuthus doriae) venom induces apoptosis and inhibits DNA synthesis in human neuroblastoma cells","volume":"348","author":"Zargan","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2018.01.133_bib28","first-page":"6","article-title":"Corrigendum: identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential","volume":"25","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2018.01.133_bib29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3727\/096504017X14900530835262","article-title":"Knockdown of Homeobox B5 (HOXB5) inhibits cell proliferation, migration, and invasion in non-small cell lung cancer cells through inactivation of the Wnt\/b -Catenin pathway","volume":"26","author":"Zhang","year":"2018","journal-title":"Oncol. Res."},{"key":"10.1016\/j.bbrc.2018.01.133_bib30","first-page":"4871","article-title":"Use of chlorotoxin for targeting of primary brain tumors","volume":"58","author":"Soroceanu","year":"1998","journal-title":"Cancer. Res."},{"key":"10.1016\/j.bbrc.2018.01.133_bib31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4314\/ajtcam.v11i5.17","article-title":"Inhibition effects of scorpion venom extracts (Buthus matensii Karsch) on the growth of human breast cancer MCF-7 cells","volume":"11","author":"Li","year":"2014","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"key":"10.1016\/j.bbrc.2018.01.133_bib32","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1002\/jcb.23166","article-title":"Analgesic-antitumor peptide inhibits proliferation and migration of SHG-44 human malignant glioma cells","volume":"112","author":"Zhao","year":"2011","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.bbrc.2018.01.133_bib33","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1016\/S0021-9258(19)49853-0","article-title":"Angiogenesis","volume":"267","author":"Folkman","year":"1992","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.01.133_bib34","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.toxicon.2016.12.001","article-title":"The small subunit of Hemilipin2, a new heterodimeric phospholipase A2 from Hemiscorpius lepturus scorpion venom, mediates the antiangiogenic effect of the whole protein","volume":"126","author":"Jridi","year":"2017","journal-title":"Toxicon"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18301487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18301487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T16:44:57Z","timestamp":1660409097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18301487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0006291X18301487"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.01.133","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RK1, the first very short peptide from Buthus occitanus tunetanus inhibits tumor cell migration, proliferation and angiogenesis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.01.133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}